Jean-Francois Trempe

Jean-Francois Trempe

McGill University

H-index: 37

North America-Canada

About Jean-Francois Trempe

Jean-Francois Trempe, With an exceptional h-index of 37 and a recent h-index of 24 (since 2020), a distinguished researcher at McGill University, specializes in the field of Parkinson disease, structural biology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Identification and structural characterization of small molecule inhibitors of PINK1

Mechanism of Ubiquitin Ligase Activation of Parkin by a Small Molecule Molecular Glue

Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress

Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease

MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX

Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin

Corrigendum: Clinical and genetic analysis of Costa Rican patients with Parkinson's disease

Gβγ subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts

Jean-Francois Trempe Information

University

Position

___

Citations(all)

5878

Citations(since 2020)

3161

Cited By

3949

hIndex(all)

37

hIndex(since 2020)

24

i10Index(all)

52

i10Index(since 2020)

48

Email

University Profile Page

McGill University

Google Scholar

View Google Scholar Profile

Jean-Francois Trempe Skills & Research Interests

Parkinson disease

structural biology

Top articles of Jean-Francois Trempe

Title

Journal

Author(s)

Publication Date

Identification and structural characterization of small molecule inhibitors of PINK1

PloS one

Vallerinteavide Mavelli Girish

Sundramurthy Kumar

Lissa Joseph

Chacko Jobichen

R Manjunatha Kini

...

2012/10/29

Mechanism of Ubiquitin Ligase Activation of Parkin by a Small Molecule Molecular Glue

Kalle Gehring

Véronique Sauvé

Eric Stefan

Nathalie Croteau

Thomas Goiran

...

2024/3/19

Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress

Proceedings of the National Academy of Sciences

Mohamed A Eldeeb

Andrew N Bayne

Armaan Fallahi

Thomas Goiran

Emma J MacDougall

...

2024/3/5

Machine learning nominates the inositol pathway and novel genes in Parkinson’s disease

Brain

Eric Yu

Roxanne Larivière

Rhalena A Thomas

Lang Liu

Konstantin Senkevich

...

2024/3

MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX

Autophagy

Mohamed A Eldeeb

Armaan Fallahi

Andrea Soumbasis

Andrew N Bayne

Jean-François Trempe

...

2024/4/8

Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin

Jean-François Trempe

Kalle Gehring

2023/4/12

Corrigendum: Clinical and genetic analysis of Costa Rican patients with Parkinson's disease

Frontiers in Neurology

Gabriel Torrealba-Acosta

Eric Yu

Tanya Lobo-Prada

Javier Ruíz-Martínez

Ana Gorostidi-Pagola

...

2023/6/15

Gβγ subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts

Journal of Biological Chemistry

Shahriar M Khan

Ryan D Martin

Andrew Bayne

Darlaine Pétrin

Kyla Bourque

...

2023/4/1

Structure-based design and characterization of Parkin-activating mutations

Life Science Alliance

Michael U Stevens

Nathalie Croteau

Mohamed A Eldeeb

Odetta Antico

Zhi Wei Zeng

...

2023/6/1

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

bioRxiv

Benoit Vanderperre

Amitha Muraleedharan

Marie-France Dorion

Frederique Larroquette

Esther Del Cid Pellitero

...

2023

GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson’s disease

Brain

Konstantin Senkevich

Cornelia E Zorca

Aliza Dworkind

Uladzislau Rudakou

Emma Somerville

...

2023/5/2

Molecular Mechanisms of Neurodegeneration in Parkinson's Disease.

Journal of Molecular Biology

Jean-François Trempe

Kalle Gehring

2023/4/27

Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4

bioRxiv

Ylauna Christine Megane Penalva

Sandra Paschkowsky

Sherilyn Junelle Recinto

Anthony Duchesne

Clemence Levet

...

2023

MTSviewer: a database to visualize mitochondrial targeting sequences, cleavage sites, and mutations on protein structures

Plos one

Andrew N Bayne

Jing Dong

Saeid Amiri

Sali MK Farhan

Jean-François Trempe

2023/4/24

Identification of novel variants, genes and pathways potentially linked to Parkinson's disease using machine learning

medRxiv

Eric Yu

Roxanne Lariviere

Rhalena A Thomas

Lang Liu

Konstantin Senkevich

...

2023

Association of Rare Variants in ARSA with Parkinson's Disease

Movement Disorders

Konstantin Senkevich

Mariia Beletskaia

Aliza Dworkind

Eric Yu

Jamil Ahmad

...

2023/10

Dissecting the interactions of PINK1 with the TOM complex in depolarized mitochondria

bioRxiv

Klaudia K Maruszczak

Martin Jung

Shafqat Rasool

Jean-François Trempe

Doron Rapaport

2022/1/13

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

medRxiv

Emily Banks

Vincent Francis

Sheng-Jia Lin

Fares Kharfallah

Vladimir Fonov

...

2022/8/26

Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex

Molecular Cell

Shafqat Rasool

Simon Veyron

Naoto Soya

Mohamed A Eldeeb

Gergely L Lukacs

...

2022/1/6

An approach to measuring protein turnover in human induced pluripotent stem cell organoids by mass spectrometry

Methods

Jing Dong

Anthony Duchesne

Andrew N Bayne

Nguyen-Vi Mohamed

Wei Yi

...

2022/7/1

See List of Professors in Jean-Francois Trempe University(McGill University)

Co-Authors

H-index: 159
Guy Rouleau

Guy Rouleau

McGill University

H-index: 78
Peter S McPherson, PhD, FRSC

Peter S McPherson, PhD, FRSC

McGill University

H-index: 71
Gergely L. Lukacs

Gergely L. Lukacs

McGill University

H-index: 70
Miroslaw Cygler

Miroslaw Cygler

University of Saskatchewan

H-index: 64
Kalle Gehring

Kalle Gehring

McGill University

H-index: 60
Jane Endicott

Jane Endicott

Newcastle University

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