Philip Anton van der Merwe
University of Oxford
H-index: 77
Europe-United Kingdom
Top articles of Philip Anton van der Merwe
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
The EMBO Journal
2024/1/2
Regulation of temporal cytokine production by co-stimulation receptors in TCR-T cells is lost in CAR-T cells
bioRxiv
2024
Using CombiCells, a platform enabling titration and combinatorial display of cell surface ligands, to investigate the sensitivity and costimulatory requirements of TCRs and CARs
bioRxiv
2023
Ligand requirements for immunoreceptor triggering
bioRxiv
2023/9/15
Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency
bioRxiv
2023/9/7
Mechanical forces impair antigen discrimination by reducing differences in T‐cell receptor/peptide–MHC off‐rates
The EMBO Journal
2023/4/3
Inefficient exploitation of accessory receptors reduces the sensitivity of chimeric antigen receptors
Proceedings of the National Academy of Sciences
2023/1/10
The molecular reach of antibodies determines their SARS-CoV-2 neutralisation potency (preprint)
2023
Ying Zhang
H-Index: 4
Chang Liu
H-Index: 7
Alain Townsend
H-Index: 26
Philip Anton Van Der Merwe
H-Index: 37
Charlotte Deane
H-Index: 34
Omer Dushek
H-Index: 24
Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering
bioRxiv
2023
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity …
PLoS Computational Biology
2022/3/2
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
Proceedings of the National Academy of Sciences
2022/3/1
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
Elife
2021/8/26
The discriminatory power of the T cell receptor
Elife
2021/5/25
Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
bioRxiv
2021/5/21
CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
Cells
2021/2/18
T cells exhibit unexpectedly low discriminatory power and can respond to ultra-low affinity peptide-MHC ligands
bioRxiv
2020/11/15
Regulated unbinding of ZAP70 at the T cell receptor by kinetic avidity
bioRxiv
2020/2/13
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