Kilian V. M. Huber
University of Oxford
H-index: 37
Europe-United Kingdom
Top articles of Kilian V. M. Huber
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3 | Bioorganic & Medicinal Chemistry Letters | Brigitt Raux Karly A Buchan James Bennett Thomas Christott Matthew S Dowling | 2024/1/15 |
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist | Journal of Medicinal Chemistry | Esra Balıkçı Anne-Sophie MC Marques Ludwig G Bauer Raina Seupel James Bennett | 2024/4/18 |
A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition | Cancer Research | Ani Michaud Elisabeth Rothweiler Cesear Corona Michael Beck Jennifer Wilkinson | 2024/3/22 |
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function | Chemical Science | Oliver D Coleman Jessica Macdonald Ben Thomson Jennifer A Ward Christopher J Stubbs | 2023 |
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions | Cell Chemical Biology | Hongchao Ji Xue Lu Shiji Zhao Qiqi Wang Bin Liao | 2023/11/16 |
Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors Using Alkyne-Functionalized Probes | Elisabeth M Rothweiler Kilian VM Huber | 2023/8/10 | |
Open resources for chemical probes and their implications for future drug discovery | Esra Balıkçı Anne-Sophie MC Marques Jesper S Hansen Kilian VM Huber | 2023/5/4 | |
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments | ChemMedChem | Paola Martinelli Otmar Schaaf Andreas Mantoulidis Laetitia J Martin Julian E Fuchs | 2023/3/14 |
Discovery of high-affinity small-molecule binders of the epigenetic reader YEATS4 | Journal of medicinal chemistry | Allyn T Londregan Karlygash Aitmakhanova James Bennett Laura J Byrnes Daniel P Canterbury | 2022/12/23 |
DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation | Cell Reports | Ruth F Ketley Federica Battistini Adele Alagia Clemence Mondielli Florence Iehl | 2022/10/25 |
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators | Elisabeth M Rothweiler Paul E Brennan Kilian VM Huber | 2022/3/28 | |
A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors | bioRxiv | Elisabeth M Rothweiler Jakub Stefaniak Jennifer A Ward Catherine Rogers Esra Balikci | 2022/1/22 |
Chemoproteomic profiling of covalent XPO1 inhibitors to assess target engagement and selectivity | ChemBioChem | Jeffrey G Martin Jennifer A Ward Felix Feyertag Lu Zhang Shalise Couvertier | 2021/6/15 |
Fragment screening reveals starting points for rational design of galactokinase 1 inhibitors to treat classic galactosemia | ACS Chemical Biology | Sabrina R Mackinnon Tobias Krojer William R Foster Laura Diaz-Saez Manshu Tang | 2021/3/16 |
TP-MAP-an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data | bioRxiv | Felix Feyertag Kilian VM Huber | 2021/2/23 |
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity | British Journal of Cancer | Adan Pinto-Fernandez Mariolina Salio Tom Partridge Jianzhou Chen George Vere | 2021/2/16 |
Importance of quantifying drug-target engagement in cells | ACS Medicinal Chemistry Letters | Jakub Stefaniak Kilian VM Huber | 2020/3/6 |
Assays to characterize the cellular pharmacology of a chemical probe | Jakub Stefaniak Sébastien RG Galan Kilian VM Huber | 2020/11/17 | |
Re-evaluating the mechanism of action of α, β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein cross-linking with Michael … | Journal of medicinal chemistry | Jennifer A Ward Adan Pinto-Fernandez LoÏc Cornelissen Sarah Bonham Laura Díaz-Sáez | 2020/2/28 |
Examination of clinically relevant inhibitor selectivity in live cells across the CDK family | Cancer Research | James Vasta Carrow Wells Cesear Corona Jennifer Wilkinson Chad Zimprich | 2020/8/15 |
Co-Authors
