John E Burke
University of Victoria
H-index: 48
North America-Canada
Top articles of John E Burke
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Molecular basis for plasma membrane recruitment of PI4KA by EFR3 | bioRxiv | Sushant Suresh Alexandria L Shaw Joshua G Pemberton Mackenzie K Scott Noah J Harris | 2024 |
Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A | bioRxiv | Alexandria L Shaw Sushant Suresh Matthew AH Parson Noah J Harris Meredith L Jenkins | 2024 |
Toxoplasma gondii mitochondrial association factor 1b interactome reveals novel binding partners including Ral GTPase accelerating protein α1 | Journal of Biological Chemistry | Cameron J Powell Meredith L Jenkins Tara B Hill Matthew L Blank Leah F Cabo | 2024/1/1 |
Novel long-acting covalent PI3Kα inhibitors boost potential action in cancer | Cancer Research | Theodora A Constantin Lukas Bissegger Erhan Keleş Luka Raguž Clara Orbegozo | 2024/3/22 |
Spartin-mediated lipid transfer facilitates lipid droplet turnover | Proceedings of the National Academy of Sciences | Neng Wan Zhouping Hong Matthew AH Parson Justin L Korfhage John E Burke | 2024/1/16 |
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11 | Journal of Biological Chemistry | Matthew C Thibodeau Noah J Harris Meredith L Jenkins Matthew AH Parson John T Evans | 2023/1/1 |
PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases | Isobel Barlow-Busch Alexandria L Shaw John E Burke | 2023/8/1 | |
Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs | Cell Reports | Manoj K Rathinaswamy Meredith L Jenkins Benjamin R Duewell Xuxiao Zhang Noah J Harris | 2023/3/28 |
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain | Elife | Noah J Harris Meredith L Jenkins Sung-Eun Nam Manoj K Rathinaswamy Matthew AH Parson | 2023/7/7 |
ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1 | Structure | Alexandria L Shaw Matthew AH Parson Linda Truebestein Meredith L Jenkins Thomas A Leonard | 2023/3/2 |
Molecular mechanisms of PI4K regulation and their involvement in viral replication | Jacob A McPhail John E Burke | 2023/3 | |
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation | Nature Communications | Yong Mi Choi Dalila Ajjaji Kaelin D Fleming Peter P Borbat Meredith L Jenkins | 2023/6/2 |
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis | Proceedings of the National Academy of Sciences | Ronja Reinhardt Kai Hirzel Gisela Link Stephan A Eisler Tanja Hägele | 2023/2/14 |
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages | bioRxiv | Timothy A Bates Mila Trank-Greene Xammy Nguyenla Aidan Anastas Sintayehu Gurmessa | 2023/12/1 |
CERT1 mutations perturb human development by disrupting sphingolipid homeostasis | The Journal of clinical investigation | Charlotte Gehin Museer A Lone Winston Lee Laura Capolupo Sylvia Ho | 2023/5/15 |
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus | Nature Communications | Meredith L Jenkins Harish Ranga-Prasad Matthew AH Parson Noah J Harris Manoj K Rathinaswamy | 2023/1/12 |
Structural basis for the conserved roles of PI4KA and its regulatory partners and their misregulation in disease | Sushant Suresh John E Burke | 2023/11/10 | |
Beyond PI3Ks: targeting phosphoinositide kinases in disease | John E Burke Joanna Triscott Brooke M Emerling Gerald RV Hammond | 2023/5 | |
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation | Nature communications | Aleksandra Levina Kaelin D Fleming John E Burke Thomas A Leonard | 2022/4/6 |
Covalent proximity scanning of a distal cysteine to target PI3Kα | Journal of the American Chemical Society | Chiara Borsari Erhan Keles Jacob A McPhail Alexander Schaefer Rohitha Sriramaratnam | 2022/3/30 |
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