Vedagopuram Sreekanth

Vedagopuram Sreekanth

Harvard University

H-index: 14

North America-United States

About Vedagopuram Sreekanth

Vedagopuram Sreekanth, With an exceptional h-index of 14 and a recent h-index of 11 (since 2020), a distinguished researcher at Harvard University, specializes in the field of Chemical Biology, CRISPR-Cas, Diabetes/Sc-βcells, Cancer-Pharmacology, Drug/Protein/Nucleic acid delivery.

His recent articles reflect a diverse array of research interests and contributions to the field:

Proteolysis-targeting chimeras with reduced off-targets

Inhibitors of RNA-guided nucleases and uses thereof

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

A molecular glue approach to control the half-life of CRISPR-based technologies

CRISPR-based therapeutics: current challenges and future applications

Vedagopuram Sreekanth Information

University

Position

Postdoctoral Research Fellow: Brigham & Women's Hospital, Harvard Medical School, Broad Institute

Citations(all)

532

Citations(since 2020)

351

Cited By

304

hIndex(all)

14

hIndex(since 2020)

11

i10Index(all)

18

i10Index(since 2020)

13

Email

University Profile Page

Harvard University

Google Scholar

View Google Scholar Profile

Vedagopuram Sreekanth Skills & Research Interests

Chemical Biology

CRISPR-Cas

Diabetes/Sc-βcells

Cancer-Pharmacology

Drug/Protein/Nucleic acid delivery

Top articles of Vedagopuram Sreekanth

Title

Journal

Author(s)

Publication Date

Proteolysis-targeting chimeras with reduced off-targets

Nature Chemistry

Tuan M Nguyen

Vedagopuram Sreekanth

Arghya Deb

Praveen Kokkonda

Praveen K Tiwari

...

2024/2

Inhibitors of RNA-guided nucleases and uses thereof

2023/10/17

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Science

Jaron AM Mercer

Stephan J DeCarlo

Shourya S Roy Burman

Vedagopuram Sreekanth

Andrew T Nelson

...

2024/3/15

Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

The Journal of Clinical Investigation

S Sengupta E Kaur

R Agrawal

R Arun

V Madhavan

V Srivastava

...

2024

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

Cell metabolism

Nicolas Wieder

Juliana Coraor Fried

Choah Kim

Eriene-Heidi Sidhom

Matthew R Brown

...

2023/5/2

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

Biorxiv

Trauner D. Arp CJ

Reynders M

Sreekanth V

Kokkonda P

Pagano M

...

2023

A molecular glue approach to control the half-life of CRISPR-based technologies

bioRxiv

Vedagopuram Sreekanth

Max Jan

Kevin T Zhao

Donghyun Lim

Jessie R Davis

...

2023/3/20

CRISPR-based therapeutics: current challenges and future applications

Trends in Pharmacological Sciences

A.E.M. Modell

D. Lim

T. Nguyen

V. Sreekanth

A. Choudhary

2022

Identifying anti-CRISPR small molecules via high-throughput assay

D Lim

V Sreekanth

A Choudhary

2022/11/17

A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules

Nature cell biology

Donghyun Lim

Qingxuan Zhou

Kurt J Cox

Benjamin K Law

Miseon Lee

...

2022/12

Zinc finger degradation domains

2023/5/18

Self-assembled Supramolecular Nanomicelles from Bile Acid-Docetaxel Conjugate are Highly Tolerable with Improved Therapeutic Efficacy

Biomaterials Science

Bajaj A. Sreekanth V

Pal S

Kumar S

Komalla V

Yadav P

...

2021

Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes.

Angewandte Chemie International Edition

Vedagopuram Sreekanth

Animesh Kar

Sandeep Kumar

Sanjay Pal

Poonam Yadav

...

2021/3/1

Novel Nucleic Acid Modifiers

2022/5/26

Methods and Compositions for Cell Therapy

2022/6/9

A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells

Science Advances

Kisuk Yang

Miseon Lee

Peter Anthony Jones

Sophie S Liu

Angela Zhou

...

2020/11/18

Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes

ACS Central Science

Vedagopuram Sreekanth

Qingxuan Zhou

Praveen Kokkonda

Heysol C Bermudez-Cabrera

Donghyun Lim

...

2020/11/18

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

Nature communications

Donghyun Lim

Vedagopuram Sreekanth

Kurt J Cox

Benjamin K Law

Bridget K Wagner

...

2020/8/13

See List of Professors in Vedagopuram Sreekanth University(Harvard University)

Co-Authors

H-index: 202
George Church

George Church

Harvard University

H-index: 143
David R. Liu

David R. Liu

Harvard University

H-index: 80
Dirk Trauner

Dirk Trauner

New York University

H-index: 72
Jeffrey M. Karp

Jeffrey M. Karp

Harvard University

H-index: 46
Martin Kampmann

Martin Kampmann

University of California, San Francisco

H-index: 46
Luca Pinello

Luca Pinello

Harvard University

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