Mitsuhiko Ikura
University of Toronto
H-index: 102
North America-Canada
Top articles of Mitsuhiko Ikura
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II | European Journal of Cell Biology | Teklab Gebregiworgis Jonathan Yui-Lai Chan Douglas A Kuntz Gilbert G Privé Christopher B Marshall | 2024/4/15 |
Aromatically stacking the odds in favour of increased ORAI1 activation. | Cell Calcium | Peter B Stathopulos Mitsuhiko Ikura | 2023/12/21 |
Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3 | Biochimie | Jonatas Erick Maimoni Campanella Sergio Luiz Ramos Junior Vanessa Thomaz Rodrigues Kiraly Antoniel Augusto Severo Gomes Andrea Coelho de Barros | 2021/12/1 |
The Self‐Association of the KRAS4b Protein is Altered by Lipid‐Bilayer Composition and Electrostatics | Angewandte Chemie | Ki‐Young Lee Mitsuhiko Ikura Christopher B Marshall | 2023/4/24 |
Structures of RGL1 RAS-association domain in complex with KRAS and the oncogenic G12V mutant | Journal of Molecular Biology | Ben J Eves Teklab Gebregiworgis Geneviève MC Gasmi-Seabrook Douglas A Kuntz Gilbert G Privé | 2022/5/15 |
Nanodisc-Based Analytical Platform for Studying Dimerization of a Peripheral Membrane Protein, KRAS4b | 한국분석과학회 학술대회 | Ki-Young Lee Mitsuhiko Ikura | 2022/5 |
Regulation of GTPase function by autophosphorylation | Molecular cell | Christian W Johnson Hyuk-Soo Seo Elizabeth M Terrell Moon-Hee Yang Fenneke KleinJan | 2022/3/3 |
Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors | Journal of Thoracic Oncology | Ku-Geng Huo Hirotsugu Notsuda Zhenhao Fang Ningdi Feng Liu Teklab Gebregiworgis | 2022/2/1 |
Distinct biochemical properties of KRAS Q61H mutant render cancer cells resistant to SHP2 inhibitors | Cancer Research | Teklab Gebregiworgis Yoshihito Kano Michael Ohh Christopher B Marshall Mitsuhiko Ikura | 2022/6/15 |
Hitting the hotspots | Nature Chemical Biology | Christopher B Marshall Mitsuhiko Ikura | 2022/6 |
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors | Nature communications | Teklab Gebregiworgis Yoshihito Kano Jonathan St-Germain Nikolina Radulovich Molly L Udaskin | 2021/11/1 |
MO14-2 KRAS Q61H mutation evades the regulation of tyrosyl phosphorylation and renders cancer cells resistant to SHP2 inhibitor | Annals of Oncology | Yoshihito Kano Teklab Gebregiworgis Christopher Marshall Mitsuhiko Ikura Satoshi Miyake | 2021/7/1 |
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs | Journal of Cell Biology | Arun A Chandrakumar Étienne Coyaud Christopher B Marshall Mitsuhiko Ikura Brian Raught | 2021/6/15 |
The p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis | Journal of Cell Science | Miguel Burgos Reginald Philippe Fabrice Antigny Paul Buscaglia Emmanuelle Masson | 2021/2/1 |
Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization | Chemical Science | Ki-Young Lee Masahiro Enomoto Teklab Gebregiworgis Geneviève MC Gasmi-Seabrook Mitsuhiko Ikura | 2021 |
Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin | Journal of Cell Science | Cao Nguyen Duong Randy Brückner Martina Schmitt Astrid F Nottebaum Laura J Braun | 2021/12/15 |
A non-canonical calmodulin target motif comprising a polybasic region and lipidated terminal residue regulates localization | Benjamin MM Grant Masahiro Enomoto Mitsuhiko Ikura Christopher B Marshall | 2020/4/15 | |
NMR in integrated biophysical drug discovery for RAS: Past, present, and future | Christopher B Marshall Fenneke KleinJan Teklab Gebregiworgis Ki-Young Lee Zhenhao Fang | 2020/11 | |
Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety | Science Signaling | Benjamin MM Grant Masahiro Enomoto Sung-In Back Ki-Young Lee Teklab Gebregiworgis | 2020/3/31 |
Real-time in-cell NMR reveals the intracellular modulation of GTP-bound levels of RAS | Cell Reports | Qingci Zhao Ryu Fujimiya Satoshi Kubo Christopher B Marshall Mitsuhiko Ikura | 2020/8/25 |
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