Michael Costanzo

Michael Costanzo

University of Toronto

H-index: 58

North America-Canada

About Michael Costanzo

Michael Costanzo, With an exceptional h-index of 58 and a recent h-index of 38 (since 2020), a distinguished researcher at University of Toronto, specializes in the field of functional genomics.

His recent articles reflect a diverse array of research interests and contributions to the field:

A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds

K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ)

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

A Highlights from MBoC Selection: Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability

Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability

Reproducibility metrics for context-specific CRISPR screens

Repression of essential cell cycle genes increases cellular fitness

Reproducibility metrics for CRISPR screens

Michael Costanzo Information

University

Position

___

Citations(all)

14759

Citations(since 2020)

6510

Cited By

11132

hIndex(all)

58

hIndex(since 2020)

38

i10Index(all)

95

i10Index(since 2020)

83

Email

University Profile Page

University of Toronto

Google Scholar

View Google Scholar Profile

Michael Costanzo Skills & Research Interests

functional genomics

Top articles of Michael Costanzo

Title

Journal

Author(s)

Publication Date

A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds

Scientific Reports

Kevin Lin

Ya-Chu Chang

Maximilian Billmann

Henry N Ward

Khoi Le

...

2024/1/30

K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ)

E Bonneil

B Albert

C Dominique

M Costanzo

C Pons

...

2023/5/4

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

Nature communications

Sylvia Varland

Rui Duarte Silva

Ine Kjosås

Alexandra Faustino

Annelies Bogaert

...

2023/10/27

A Highlights from MBoC Selection: Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability

Molecular Biology of the Cell

Prashant K Mishra

Wei-Chun Au

Pedro G Castineira

Nazrin Ali

John Stanton

...

2023/9/9

Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability

Molecular Biology of the Cell

Prashant K Mishra

Wei-Chun Au

Pedro G Castineira

Nazrin Ali

John Stanton

...

2023/9/1

Reproducibility metrics for context-specific CRISPR screens

Cell Systems

Maximilian Billmann

Henry N Ward

Michael Aregger

Michael Costanzo

Brenda J Andrews

...

2023/5/17

Repression of essential cell cycle genes increases cellular fitness

PLoS genetics

Michelle M Conti

Julie M Ghizzoni

Ana Gil-Bona

Wen Wang

Michael Costanzo

...

2022/8/29

Reproducibility metrics for CRISPR screens

bioRxiv

Maximilian Billmann

Henry N Ward

Michael Aregger

Michael Costanzo

Brenda J Andrews

...

2022/2/19

Environmental robustness of the global yeast genetic interaction network

Science

Michael Costanzo

Jing Hou

Vincent Messier

Justin Nelson

Mahfuzur Rahman

...

2021/5/7

A method for benchmarking genetic screens reveals a predominant mitochondrial bias

Molecular Systems Biology

Mahfuzur Rahman

Maximilian Billmann

Michael Costanzo

Michael Aregger

Amy HY Tong

...

2021/5

Reduced gene dosage of histone H4 prevents CENP-A mislocalization and chromosomal instability in Saccharomyces cerevisiae

Genetics

Jessica R Eisenstatt

Kentaro Ohkuni

Wei-Chun Au

Olivia Preston

Loran Gliford

...

2021/5/1

τ-sga: synthetic genetic array analysis for systematically screening and quantifying trigenic interactions in yeast

Elena Kuzmin

Mahfuzur Rahman

Benjamin VanderSluis

Michael Costanzo

Chad L Myers

...

2021/2

Tubulin isotypes optimize distinct spindle positioning mechanisms during yeast mitosis

Journal of Cell Biology

Emmanuel T Nsamba

Abesh Bera

Michael Costanzo

Charles Boone

Mohan L Gupta Jr

2021/11/5

Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase

Molecular cell

Ka-Yiu Edwin Kong

Bernd Fischer

Matthias Meurer

Ilia Kats

Zhaoyan Li

...

2021/6/3

Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

Science

Elena Kuzmin

Benjamin VanderSluis

Alex N Nguyen Ba

Wen Wang

Elizabeth N Koch

...

2020/6/26

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Nature metabolism

Michael Aregger

Keith A Lawson

Maximillian Billmann

Michael Costanzo

Amy HY Tong

...

2020/6

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics

Jessica R Eisenstatt

Lars Boeckmann

Wei-Chun Au

Valerie Garcia

Levi Bursch

...

2020/6/1

Skp, cullin, F-box (SCF)-Met30 and SCF-Cdc4-mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in budding yeast

PLoS genetics

Wei-Chun Au

Tianyi Zhang

Prashant K Mishra

Jessica R Eisenstatt

Robert L Walker

...

2020/2/7

Major functional bias for mitochondrial complexes in genome-wide CRISPR screens

bioRxiv

Mahfuzur Rahman

Maximilian Billmann

Michael Costanzo

Michael Aregger

Amy HY Tong

...

2020/8/31

See List of Professors in Michael Costanzo University(University of Toronto)

Co-Authors

H-index: 111
Charles Boone

Charles Boone

University of Toronto

H-index: 111
Gary Bader

Gary Bader

University of Toronto

H-index: 76
Frederick P (Fritz) Roth

Frederick P (Fritz) Roth

University of Toronto

H-index: 72
Olga Troyanskaya

Olga Troyanskaya

Princeton University

H-index: 68
Jason Moffat

Jason Moffat

University of Toronto

H-index: 67
Chad Myers

Chad Myers

University of Minnesota-Twin Cities

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