Kevin MacKenzie
Baylor College of Medicine
H-index: 26
North America-United States
Top articles of Kevin MacKenzie
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1 | ACS Medicinal Chemistry Letters | Secondra Holmes Prashi Jain Kenneth Guzman Rodriguez Jade Williams Zhifeng Yu | 2024/1/2 |
CYP3A Mediates an Unusual C (sp2)‐C (sp3) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism | Angewandte Chemie | Xuan Qin Yong Wang Qiuji Ye John M Hakenjos Jin Wang | 2024/4/4 |
Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy | Journal of Medicinal Chemistry | Dong Lu Jianwei Chen Li Qin Imani Bijou Ping Yi | 2024/3/29 |
Expanding Complex Morpholines Using Systematic Chemical Diversity | Organic Letters | Sunny Ann Tang Afton Fults Shelton R Boyd Nikhil Gattu Kevin A Tran | 2024/3/20 |
Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity | Saleh M Khalil Kevin R MacKenzie Mirjana Maletic-Savatic Feng Li | 2024/2/1 | |
Impairing Cytochrome P450-mediated metabolism aggravates the hepatoxicity of serotonin and norepinephrine reuptake inhibitor duloxetine | Feng Li Xuan Qin John M Hakenjos Kevin Mackenzie Lei Guo | 2023/6/1 | |
Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles | Chemistry–A European Journal | Amol B Viveki Timothy M Mansfield Kevin A Tran Evan Lenkeit Kevin R MacKenzie | 2023/10/2 |
SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra | bioRxiv | Xu Han Wanli Wang Li-Hua Ma Ismael Al-Ramahi Juan Botas | 2023/2/22 |
SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra | Bioinformatics | Xu Han Wanli Wang Li-Hua Ma Ismael Ai-Ramahi Juan Botas | 2023/10/1 |
The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice | European Journal of Pharmaceutical Sciences | Xuan Qin Cen Xie John M Hakenjos Kevin R MacKenzie Shelton R Boyd | 2023/2/1 |
Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches | Chemical Research in Toxicology | Xuan Qin Yong Wang Kevin R MacKenzie John M Hakenjos Si Chen | 2023/8/2 |
Advancing ASMS with LC‐MS/MS for the discovery of novel PDCL2 ligands from DNA‐encoded chemical library selections | Andrology | Qiuji Ye Hassane Belabed Yong Wang Zhifeng Yu Murugesan Palaniappan | 2023/7 |
Metabolomics reveals a unique CYP3A-mediated C (sp3)-C (sp2) bond cleavage via ipso-addition reaction in drug metabolism | Feng Li Xuan Qin Yong Wang Kevin Mackenzie Qiuji Ye | 2023/6/5 | |
Metabolism of a selective serotonin and norepinephrine reuptake inhibitor duloxetine in liver microsomes and mice | Drug Metabolism and Disposition | Xuan Qin John M Hakenjos Kevin R MacKenzie Mercedes Barzi Hemantkumar Chavan | 2022/2/1 |
An auto-inhibited state of protein kinase G and implications for selective activation | bioRxiv | Rajesh Sharma Jeong Joo Kim Liying Qin Philipp Henning Madoka Akimoto | 2022/1/1 |
A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1, 2-Diamines | Molecules | Srinivas Chamakuri Sunny Ann Tang Kevin A Tran Shiva Krishna Reddy Guduru Peter K Bolin | 2022/5/25 |
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis | Proceedings of the National Academy of Sciences | Prasanna Kandel Fatih Semerci Rachana Mishra William Choi Aleksandar Bajic | 2022/3/29 |
Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization | Nature communications | Rajesh Sharma Kyoung-Jae Choi My Diem Quan Sonum Sharma Banumathi Sankaran | 2021/9/22 |
CYP3A Mediated Metabolism of Tyrosine Kinase Inhibitor Pexidartinib and Alleviated its Cytotoxicity to HepG2 Cells | The FASEB Journal | Xuan Qin John Hakenjos Kevin MacKenzie Si Chen Lei Guo | 2021/5 |
Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery | Scientific Reports | Lyra Chang James Campbell Idris O Raji Shiva KR Guduru Prasanna Kandel | 2021/1/13 |
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