Mark A. Lemmon, Ph.D., F.R.S.

Mark A. Lemmon, Ph.D., F.R.S.

Yale University

H-index: 93

North America-United States

About Mark A. Lemmon, Ph.D., F.R.S.

Mark A. Lemmon, Ph.D., F.R.S., With an exceptional h-index of 93 and a recent h-index of 44 (since 2020), a distinguished researcher at Yale University, specializes in the field of Growth factor receptors, Cancer biology, Biochemistry, Structural biology, Signaling.

His recent articles reflect a diverse array of research interests and contributions to the field:

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SME and molecular dynamics simulations

Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma

Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling

Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations

Dynamics of protein kinases and pseudokinases by HDX-MS

Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations

Looking lively: emerging principles of pseudokinase signaling

Mark A. Lemmon, Ph.D., F.R.S. Information

University

Position

David A. Sackler Professor of Pharmacology Co-Director Cancer Biology Institute

Citations(all)

38309

Citations(since 2020)

8734

Cited By

32369

hIndex(all)

93

hIndex(since 2020)

44

i10Index(all)

146

i10Index(since 2020)

113

Email

University Profile Page

Yale University

Google Scholar

View Google Scholar Profile

Mark A. Lemmon, Ph.D., F.R.S. Skills & Research Interests

Growth factor receptors

Cancer biology

Biochemistry

Structural biology

Signaling

Top articles of Mark A. Lemmon, Ph.D., F.R.S.

Title

Journal

Author(s)

Publication Date

Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SME and molecular dynamics simulations

Biophysical Journal

Mia A Rosenfeld

Fiona L Kearns

Joann Chongsaritsinsuk

Alexandra Steigmeyer

Keira E Mahoney

...

2024/2/8

Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

Cell reports

Krishna C Mudumbi

Eric A Burns

David J Schodt

Zaritza O Petrova

Anatoly Kiyatkin

...

2024/1/23

Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma

Nature Communications

Esther R Berko

Gabriela M Witek

Smita Matkar

Zaritza O Petrova

Megan A Wu

...

2023/5/5

Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling

bioRxiv

Henning Mühlenbeck

Yuko Tsutsui

Mark A Lemmon

Kyle W Bender

Cyril Zipfel

2023/8/24

Efficacy of osimertinib in patients with lung cancer positive for uncommon EGFR exon 19 deletion mutations

Clinical Cancer Research

Michael J Grant

Jacqueline V Aredo

Jacqueline H Starrett

Paul Stockhammer

Iris K van Alderwerelt van Rosenburgh

...

2023/6/1

Dynamics of protein kinases and pseudokinases by HDX-MS

Joshua B Sheetz

Mark A Lemmon

Yuko Tsutsui

2022/1/1

Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations

Nature communications

Iris K van Alderwerelt van Rosenburgh

David M Lu

Michael J Grant

Steven E Stayrook

Manali Phadke

...

2022/11/10

Looking lively: emerging principles of pseudokinase signaling

Joshua B Sheetz

Mark A Lemmon

2022/10/1

A Prosperous Future

J. Biochem.

Mark A Lemmon

2022/9

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias

Nature

Chun Hu

Carlos A Leche

Anatoly Kiyatkin

Zhaolong Yu

Steven E Stayrook

...

2022/2/17

Glioblastoma mutations impair ligand discrimination by EGFR

bioRxiv

Chun Hu

Carlos A Leche

Anatoly Kiyatkin

Steven E Stayrook

Kathryn M Ferguson

...

2021/5/4

Structural basis for ligand reception by anaplastic lymphoma kinase

Nature

Tongqing Li

Steven E Stayrook

Yuko Tsutsui

Jianan Zhang

Yueyue Wang

...

2021/12/2

Drugging the “undruggable” MYCN oncogenic transcription factor: overcoming previous obstacles to impact childhood cancers

Adam J Wolpaw

Richard Bayliss

Gabriele Büchel

Chi V Dang

Martin Eilers

...

2021/4/1

ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes

Cell reports

Fumin Shi

Jeannine M Mendrola

Joshua B Sheetz

Neo Wu

Anselm Sommer

...

2021/10/19

Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation

Proceedings of the National Academy of Sciences

Keshav Patil

Earl Joseph Jordan

Jin H Park

Krishna Suresh

Courtney M Smith

...

2021/3/9

Phosphatidylserine binding directly regulates TIM-3 function

Biochemical Journal

Courtney M Smith

Alice Li

Nithya Krishnamurthy

Mark A Lemmon

2021/9/17

Abstract PO032: TIM3 regulation by phosphatidylserine

Cancer Immunology Research

Courtney M Smith

Alice Li

Nithya Krishnamurthy

Mark A Lemmon

2021/2/1

Phosphatidylserine binding regulates TIM-3 effects on T cell receptor signaling

bioRxiv

Courtney M Smith

Alice Li

Nithya Krishnamurthy

Mark A Lemmon

2021/5/8

Regulation of TIM-3 by Phosphatidylserine

Courtney McCaul Smith

2021

Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Cancer research

Jacqueline H Starrett

Alexis A Guernet

Maria Emanuela Cuomo

Kamrine E Poels

Iris K van Alderwerelt van Rosenburgh

...

2020/5/15

See List of Professors in Mark A. Lemmon, Ph.D., F.R.S. University(Yale University)

Co-Authors

H-index: 195
Joseph Schlessinger

Joseph Schlessinger

Yale University

H-index: 129
Axel Brunger

Axel Brunger

Stanford University

H-index: 99
Donald Engelman

Donald Engelman

Yale University

H-index: 72
John Ladbury

John Ladbury

University of Leeds

H-index: 68
Marcelo Kazanietz

Marcelo Kazanietz

University of Pennsylvania

H-index: 67
Michael S. Marks

Michael S. Marks

University of Pennsylvania

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