Ian Robert Hardcastle
Newcastle University
H-index: 37
Europe-United Kingdom
Top articles of Ian Robert Hardcastle
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile | American Association for Cancer Research Annual Meeting | Maria Ahn Luke Bevan Ildiko Buck Celine Cano Juan Castro | 2024/3/22 |
Targeting the MDM2-p53 interaction: Time-and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index | Cancer Research | Elaine Willmore Maria Ahn Suzanne Kyle Yan Zhao Huw Thomas | 2024/3/22 |
Intermediates of isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity | 2023/3/22 | ||
IZOINDOLINONOWE INHIBITORY INTERAKCJI MDM2-P53 MAJĄCE DZIAŁANIE PRZEClWNOWOTWOROWE | 2023/1/23 | ||
Isoindolinonhæmmere af mdm2-p53-interaktionen med anticanceraktivitet | 2022/12/19 | ||
Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLites─ Halogenated probes of druglike and peptide-like molecular interactions | Journal of Medicinal Chemistry | Gemma Davison Mathew P Martin Shannon Turberville Selma Dormen Richard Heath | 2022/11/11 |
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor | Journal of Medicinal Chemistry | Duncan C Miller Tristan Reuillon Lauren Molyneux Timothy Blackburn Simon J Cook | 2022/4/25 |
Isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity | 2022/4/7 | ||
Structure-based design of potent and orally active isoindolinone inhibitors of MDM2-p53 protein–protein interaction | Journal of Medicinal Chemistry | Gianni Chessari Ian R Hardcastle Jong Sook Ahn Burcu Anil Elizabeth Anscombe | 2021/3/24 |
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase | Journal of medicinal chemistry | Islam Al-Khawaldeh Mohammed J Al Yasiri Gregory G Aldred Christine Basmadjian Cinzia Bordoni | 2021/7/2 |
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase | RSC Medicinal Chemistry | Christopher J Matheson Christopher R Coxon Richard Bayliss Kathy Boxall Benoit Carbain | 2020 |
Co-Authors
