Celine Cano
Newcastle University
H-index: 25
Europe-United Kingdom
Top articles of Celine Cano
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile | American Association for Cancer Research Annual Meeting | Maria Ahn Luke Bevan Ildiko Buck Celine Cano Juan Castro | 2024/3/22 |
Targeting the MDM2-p53 interaction: Time-and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index | Cancer Research | Elaine Willmore Maria Ahn Suzanne Kyle Yan Zhao Huw Thomas | 2024/3/22 |
A beginner’s guide to current synthetic linker strategies towards VHL-recruiting PROTACs | Nikol A Zografou-Barredo Alex J Hallatt Jennyfer Goujon-Ricci Céline Cano | 2023/5/18 | |
Modulation of ERK5 activity as a therapeutic anti-cancer strategy | Duncan C Miller Suzannah J Harnor Mathew P Martin Richard A Noble Stephen R Wedge | 2023/4/1 | |
Mapping ligand interactions of bromodomains BRD4 and ATAD2 with FragLites and PepLites─ Halogenated probes of druglike and peptide-like molecular interactions | Journal of Medicinal Chemistry | Gemma Davison Mathew P Martin Shannon Turberville Selma Dormen Richard Heath | 2022/11/11 |
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor | Journal of Medicinal Chemistry | Duncan C Miller Tristan Reuillon Lauren Molyneux Timothy Blackburn Simon J Cook | 2022/4/25 |
Advanced approaches of developing targeted covalent drugs | Conghao Gai Suzannah J Harnor Shihao Zhang Céline Cano Chunlin Zhuang | 2022 | |
Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides | Journal of Heterocyclic Chemistry | Edwige MH Picazo Amy B Heptinstall David M Wilson Céline Cano Bernard T Golding | 2021/4 |
Structure-based design of potent and orally active isoindolinone inhibitors of MDM2-p53 protein–protein interaction | Journal of Medicinal Chemistry | Gianni Chessari Ian R Hardcastle Jong Sook Ahn Burcu Anil Elizabeth Anscombe | 2021/3/24 |
Isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity | 2022/4/7 | ||
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase | Journal of medicinal chemistry | Islam Al-Khawaldeh Mohammed J Al Yasiri Gregory G Aldred Christine Basmadjian Cinzia Bordoni | 2021/7/2 |
Synthetic cannabinoid receptor agonists: classification and nomenclature | AJ Potts C Cano SHL Thomas SL Hill | 2020/2/1 | |
Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge | Diabetes, Obesity and Metabolism | Brian E Ford Shruti S Chachra Ahmed Alshawi Alfie Brennan Suzannah Harnor | 2020/11 |
Molecular dynamics simulations reveal the determinants of cyclin-dependent kinase 2 inhibition by 5-nitrosopyrimidine derivatives | Journal of Biomolecular Structure and Dynamics | Stefano Guglielmo Daniela Cortese Celine Cano Roberta Fruttero | 2020/9/1 |
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy | The Journal of clinical investigation | Catherine E Willoughby Yanyan Jiang Huw D Thomas Elaine Willmore Suzanne Kyle | 2020/1/2 |
Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine | Biochemical Journal | Matthew J Byrne Nazia Nasir Christine Basmadjian Chitra Bhatia Rory F Cunnison | 2020/4/30 |
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase | RSC Medicinal Chemistry | Christopher J Matheson Christopher R Coxon Richard Bayliss Kathy Boxall Benoit Carbain | 2020 |
