Claudia Robertson

Claudia Robertson

Baylor College of Medicine

H-index: 98

North America-United States

About Claudia Robertson

Claudia Robertson, With an exceptional h-index of 98 and a recent h-index of 51 (since 2020), a distinguished researcher at Baylor College of Medicine, specializes in the field of traumatic brain injury.

His recent articles reflect a diverse array of research interests and contributions to the field:

Oxidized activated charcoal nanozymes: Synthesis, and optimization for in vitro and in vivo bioactivity for traumatic brain injury

Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients

Temporal Profiles of P-Tau, T-Tau, and P-Tau: Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6–12 Month …

Serial Measurements of Serum Glial Fibrillary Acidic Protein in Moderate-Severe Traumatic Brain Injury: Potential Utility in Providing Insights into Secondary Insults and Long …

Parallel CSF and serum temporal profile assessment of axonal injury biomarkers NF-L and pNF-H: Associations with patient outcome in moderate-severe traumatic brain injury

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study

Clinical outcomes after traumatic brain injury and exposure to extracranial surgery: a TRACK-TBI Study

Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury

Claudia Robertson Information

University

Baylor College of Medicine

Position

Professor of Neurosurgery

Citations(all)

34479

Citations(since 2020)

10851

Cited By

27652

hIndex(all)

98

hIndex(since 2020)

51

i10Index(all)

300

i10Index(since 2020)

182

Email

University Profile Page

Baylor College of Medicine

Claudia Robertson Skills & Research Interests

traumatic brain injury

Top articles of Claudia Robertson

Oxidized activated charcoal nanozymes: Synthesis, and optimization for in vitro and in vivo bioactivity for traumatic brain injury

Authors

Emily A McHugh,Anton V Liopo,Kimberly Mendoza,Claudia S Robertson,Gang Wu,Zhe Wang,Weiyin Chen,Jacob L Beckham,Paul J Derry,Thomas A Kent,James M Tour

Journal

Advanced Materials

Published Date

2024/3

Carbon‐based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as antioxidants are, however, poorly understood. Here, the process–structure–property–performance properties of coconut‐derived oxidized activated charcoal (cOAC) nano‐SOD mimetics are studied by analyzing how modifications to the nanomaterial's synthesis impact the size, as well as the elemental and electrochemical properties of the particles. These properties are then correlated to the in vitro antioxidant bioactivity of poly(ethylene glycol)‐functionalized cOACs (PEG‐cOAC). Chemical oxidative treatment methods that afford smaller, more homogeneous cOAC nanoparticles with higher levels of quinone functionalization show enhanced protection against oxidative …

Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients

Authors

Manish Bhomia,Yanru Feng,Piper Deleon,Claudia S Robertson,Firas Kobeissy,Kevin K Wang,Barbara Knollmann-Ritschel

Journal

International Journal of Molecular Sciences

Published Date

2024/2/28

Traumatic brain injury (TBI) is defined as an injury to the brain by external forces which can lead to cellular damage and the disruption of normal central nervous system functions. The recently approved blood-based biomarkers GFAP and UCH-L1 can only detect injuries which are detectable on CT, and are not sensitive enough to diagnose milder injuries or concussion. Exosomes are small microvesicles which are released from the cell as a part of extracellular communication in normal as well as diseased states. The objective of this study was to identify the messenger RNA content of the exosomes released by injured neurons to identify new potential blood-based biomarkers for TBI. Human severe traumatic brain injury samples were used for this study. RNA was isolated from neuronal exosomes and total transcriptomic sequencing was performed. RNA sequencing data from neuronal exosomes isolated from serum showed mRNA transcripts of several neuronal genes. In particular, mRNAs of several olfactory receptor genes were present at elevated concentrations in the neuronal exosomes. Some of these genes were OR10A6, OR14A2, OR6F1, OR1B1, and OR1L1. RNA sequencing data from exosomes isolated from CSF showed a similar elevation of these olfactory receptors. We further validated the expression of these samples in serum samples of mild TBI patients, and a similar up-regulation of these olfactory receptors was observed. The data from these experiments suggest that damage to the neurons in the olfactory neuroepithelium as well as in the brain following a TBI may cause the release of mRNA from these receptors in the …

Temporal Profiles of P-Tau, T-Tau, and P-Tau: Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6–12 Month …

Authors

Richard Rubenstein,Leah McQuillan,Kevin KW Wang,Claudia Robertson,Binggong Chang,Zhihui Yang,Haiyan Xu,John Williamson,Amy K Wagner

Journal

Journal of Neurotrauma

Published Date

2024/2/1

Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to increased risk of neurodegenerative diseases known as “tauopathies.” Increased post-TBI tau hyperphosphorylation has been reported in brain tissue and biofluids. Acute-to-chronic TBI total (T)-tau and phosphorylated (P)-tau temporal profiles in the cerebrospinal fluid (CSF) and serum and their relationship to global outcome is unknown. Our multi-site longitudinal study examines these concurrent profiles acutely (CSF and serum) and also characterizes the acute- to-chronic serum patterns. Serial serum and CSF samples from individuals with moderate-to-severe TBI were obtained from two cohorts (acute, subacute, and chronic samples from University of Pittsburgh [UPitt] [n = 286 unique subjects] and acute samples from Baylor College of Medicine [BCM] [n = 114 unique subjects]) and assayed for T-tau and P-tau using …

Serial Measurements of Serum Glial Fibrillary Acidic Protein in Moderate-Severe Traumatic Brain Injury: Potential Utility in Providing Insights into Secondary Insults and Long …

Authors

Claudia S Robertson,Felipe Salinas Martinez,Leah E McQuillan,John Williamson,Damon G Lamb,Kevin KW Wang,Richard Rubenstein,Amy K Wagner

Journal

Journal of Neurotrauma

Published Date

2024/1/1

In patients with traumatic brain injury (TBI), serum biomarkers may have utility in assessing the evolution of secondary brain injury. A panel of nine brain-injury- associated biomarkers was measured in archived serum samples over 10 days post-injury from 100 patients with moderate-severe TBI. Among the biomarkers evaluated, serum glial fibrillary acidic protein (GFAP) had the strongest associations with summary measures of acute pathophysiology, including intracranial pressure (ICP), cerebral perfusion pressure (CPP), and brain tissue pO2 (PbtO2). Group based trajectory (TRAJ) analysis was used to identify three distinct GFAP subgroups. The low TRAJ group (n = 23) had peak levels of 9.4 + 1.2 ng/mL that declined rapidly. The middle TRAJ group (n = 48) had higher peak values (31.5 + 5.0 ng/mL) and a slower decline over time. The high TRAJ group (n = 26) had very high, sustained peak values …

Parallel CSF and serum temporal profile assessment of axonal injury biomarkers NF-L and pNF-H: Associations with patient outcome in moderate-severe traumatic brain injury

Authors

Kevin KW Wang,David J Barton,Leah McQuillan,Firas Kobeissy,Guangzheng Cai,Haiyan Xu,Zhihui Yang,Erin Trifilio,John B Williamson,Richard Rubenstein,Claudia S Robertson,Amy K Wagner

Journal

Journal of Neurotrauma

Published Date

2024/4/8

Neurofilament-light chain (NF-L) and phosphorylated neurofilament-heavy chain (pNF-H) are axonal proteins that have been reported as potential diagnostic and prognostic biomarkers in traumatic brain injury (TBI). However, detailed temporal profiles for these proteins in blood, and interrelationships in the acute and chronic time periods post-TBI have not been established. Our objectives were 1) to characterize acute-to-chronic serum NF-L and pNF-H profiles after moderate-severe TBI, as well as acute cerebrospinal fluid (CSF) levels, 2) to evaluate CSF and serum NF-L and pNF-H associations with each other, and 3) to assess biomarker associations with global patient outcome using both the Glasgow Outcome Scale-Extended (GOS-E) and Disability Rating Scale (DRS). In this multi-cohort study, we measured serum and CSF NF-L and pNF-H levels in samples collected from two clinical cohorts (University of …

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study

Authors

John K Yue,Esther Lim Yuh,Mahmoud M Elguindy,Xiaoying Sun,Thomas Arjan Van Essen,Hansen Deng,Patrick J Belton,Gabriela G Satris,Justin C Wong,Alex Valadka,Frederick Kofi Korley,Claudia S Robertson,Michael McCrea,Murray B Stein,Ramon Diaz-Arrastia,Kevin KW Wang,Nancy Temkin,Anthony Michael DiGiorgio,Phiroz E Tarapore,Michael C Huang,Amy Markowitz,Ava M Puccio,Pratik Mukherjee,David O Okonkwo,Sonia Jain,Geoffrey T Manley

Journal

Journal of Neurotrauma

Published Date

2024/3/7

Isolated traumatic subarachnoid hemorrhage (tSAH) after traumatic brain injury (TBI) on head computed tomography (CT) scan is often regarded as a “mild” injury, with reduced need for additional workup. However, tSAH is also a predictor of incomplete recovery and unfavorable outcome. This study aimed to evaluate the characteristics of CT-occult intracranial injuries on brain magnetic resonance imaging (MRI) scan in TBI patients with emergency department (ED) arrival Glasgow Coma Scale (GCS) score 13-15 and isolated tSAH on CT. The prospective, 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (TRACK-TBI; enrollment years 2014-2019) enrolled participants who presented to the ED and received a clinically-indicated head CT within 24 hours (h) of TBI. A subset of TRACK-TBI participants underwent venipuncture within 24h for plasma glial fibrillary acidic protein …

Clinical outcomes after traumatic brain injury and exposure to extracranial surgery: a TRACK-TBI Study

Authors

Christopher J Roberts,Jason Barber,Nancy R Temkin,Athena Dong,Claudia S Robertson,Alex B Valadka,John K Yue,Amy J Markowitz,Geoffrey T Manley,Lindsay D Nelson,Neeraj Badjatia,Ramon Diaz-Arrastia,Ann-Christine Duhaime,V Ramana Feeser,Shankar Gopinath,Ramesh Grandhi,Ruchira Jha,C Dirk Keene,Christopher Madden,Michael McCrea,Randall Merchant,Laura B Ngwenya,Richard B Rodgers,David Schnyer,Sabrina R Taylor,Ross Zafonte

Journal

JAMA surgery

Published Date

2024/3/1

ImportanceTraumatic brain injury (TBI) is associated with persistent functional and cognitive deficits, which may be susceptible to secondary insults. The implications of exposure to surgery and anesthesia after TBI warrant investigation, given that surgery has been associated with neurocognitive disorders.ObjectiveTo examine whether exposure to extracranial (EC) surgery and anesthesia is related to worse functional and cognitive outcomes after TBI.Design, Setting, and ParticipantsThis study was a retrospective, secondary analysis of data from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study, a prospective cohort study that assessed longitudinal outcomes of participants enrolled at 18 level I US trauma centers between February 1, 2014, and August 31, 2018. Participants were 17 years or older, presented within 24 hours of trauma, were admitted to an inpatient unit …

Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury

Authors

Lindsay D Nelson,Nancy R Temkin,Jason Barber,Benjamin L Brett,David O Okonkwo,Michael A McCrea,Joseph T Giacino,Yelena G Bodien,Claudia Robertson,John D Corrigan,Ramon Diaz-Arrastia,Amy J Markowitz,Geoffrey T Manley,TRACK-TBI Investigators

Journal

JAMA Network Open

Published Date

2023/3/1

ImportanceMany level I trauma center patients experience clinical sequelae at 1 year following traumatic brain injury (TBI). Longer-term outcome data are needed to develop better monitoring and rehabilitation services.ObjectiveTo examine functional recovery, TBI-related symptoms, and quality of life from 1 to 5 years postinjury.Design, Setting, and ParticipantsThis cohort study enrolled trauma patients across 18 US level I trauma centers between 2014 and 2018. Eligible participants were enrolled within 24 hours of injury and followed up to 5 years postinjury. Data were analyzed January 2023.ExposuresMild TBI (mTBI), moderate-severe TBI (msTBI), or orthopedic traumatic controls (OTC).Main Outcomes and MeasuresFunctional independence (Glasgow Outcome Scale-Extended [GOSE] score 5 or higher), complete functional recovery (GOSE score, 8), better (ie, lower) TBI-related symptom burden (Rivermead …

Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study

Authors

Raquel C Gardner,Ava M Puccio,Frederick K Korley,Kevin KW Wang,Ramon Diaz-Arrastia,David O Okonkwo,Ross C Puffer,Esther L Yuh,John K Yue,Xiaoying Sun,Sabrina R Taylor,Pratik Mukherjee,Sonia Jain,Geoffrey T Manley

Journal

Brain communications

Published Date

2023/2/1

Older adults have the highest incidence of traumatic brain injury globally. Accurate blood-based biomarkers are needed to assist with diagnosis of patients across the spectrum of age and time post-injury. Several reports have suggested lower accuracy for blood-based biomarkers in older adults, and there is a paucity of data beyond day-1 post-injury. Our aims were to investigate age-related differences in diagnostic accuracy and 2-week evolution of four leading candidate blood-based traumatic brain injury biomarkers—plasma glial fibrillary acidic protein, ubiquitin carboxy-terminal hydrolase L1, S100 calcium binding protein B and neuron-specific enolase—among participants in the 18-site prospective cohort study Transforming Research And Clinical Knowledge in Traumatic Brain Injury. Day-1 biomarker data were available for 2602 participants including 2151 patients with traumatic brain injury, 242 …

Cerebral microdialysis and glucopenia in traumatic brain injury: A review

Authors

Himanshu Sharma,John P McGinnis,Katherine E Kabotyanski,Shankar P Gopinath,Jerry C Goodman,Claudia Robertson,Jovany Cruz Navarro

Published Date

2023/1/27

Traditionally, intracranial pressure (ICP) and partial brain tissue oxygenation (PbtO2) have been the primary invasive intracranial measurements used to guide management in patients with severe traumatic brain injury (TBI). After injury however, the brain develops an increased metabolic demand which may require an increment in the oxidative metabolism of glucose. Simultaneously, metabolic, and electrical dysfunction can lead to an inability to meet these demands, even in the absence of ischemia or increased intracranial pressure. Cerebral microdialysis provides the ability to accurately measure local concentrations of various solutes including lactate, pyruvate, glycerol and glucose. Experimental and clinical data demonstrate that such measurements of cellular metabolism can yield critical missing information about a patient's physiologic state and help limit secondary damage. Glucose management in traumatic brain injury is still an unresolved question. As cerebral glucose metabolism may be uncoupled from systemic glucose levels due to the metabolic dysfunction, measurement of cerebral extracellular glucose concentrations could provide more predictive information and prove to be a better biomarker to avoid secondary injury of at-risk brain tissue. Based on data obtained from cerebral microdialysis, specific interventions such as ICP-directed therapy, blood glucose increment, seizure control, and/or brain oxygen optimization can be instituted to minimize or prevent secondary insults. Thus, microdialysis measurements of parenchymal metabolic function provides clinically valuable information that cannot be obtained by other monitoring …

Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury

Authors

Murray B Stein,Sonia Jain,Livia Parodi,Karmel W Choi,Adam X Maihofer,Lindsay D Nelson,Pratik Mukherjee,Xiaoying Sun,Feng He,David O Okonkwo,Joseph T Giacino,Frederick K Korley,Mary J Vassar,Claudia S Robertson,Michael A McCrea,Nancy Temkin,Amy J Markowitz,Ramon Diaz-Arrastia,Jonathan Rosand,Geoffrey T Manley,TRACK-TBI Investigators Badjatia Neeraj 21 Duhaime Ann-Christine 22 Ferguson Adam R. 16 17 Gopinath Shankar 18 Grandhi Ramesh 23 Madden Christopher 24 Merchant Randall 25 Schnyer David 26 Taylor Sabrina R. 16 17 Yue John K. 16 17 Zafonte Ross 13 14

Journal

Translational psychiatry

Published Date

2023/1/25

Many patients with mild traumatic brain injury (mTBI) are at risk for mental health problems such as posttraumatic stress disorder (PTSD). The objective of this study was to determine whether the polygenic risk for PTSD (or for related mental health disorders or traits including major depressive disorder [MDD] and neuroticism [NEU]) was associated with an increased likelihood of PTSD in the aftermath of mTBI. We used data from individuals of European ancestry with mTBI enrolled in TRACK-TBI (n = 714), a prospective longitudinal study of level 1 trauma center patients. One hundred and sixteen mTBI patients (16.3%) had probable PTSD (PCL-5 score ≥33) at 6 months post-injury. We used summary statistics from recent GWAS studies of PTSD, MDD, and NEU to generate polygenic risk scores (PRS) for individuals in our sample. A multivariable model that included age, sex, pre-injury history of mental disorder …

Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study

Authors

Andrew M Bryant,Nathan B Rose,Nancy R Temkin,Jason K Barber,Geoffrey T Manley,Michael A McCrea,Lindsay D Nelson,Neeraj Badjatia,Shankar Gopinath,C Dirk Keene,Christopher Madden,Laura B Ngwenya,Ava Puccio,Claudia Robertson,David Schnyer,Sabrina R Taylor,John K Yue,TRACK-TBI Investigators

Journal

JAMA Network Open

Published Date

2023/12/1

ImportanceCognitive dysfunction is common after traumatic brain injury (TBI), with a well-established dose-response relationship between TBI severity and likelihood or magnitude of persistent cognitive impairment. However, patterns of cognitive dysfunction in the long-term (eg, 6-month) recovery period are less well known.ObjectiveTo characterize the prevalence of cognitive dysfunction within and across cognitive domains (processing speed, memory, and executive functioning) 6 months after injury in patients with TBI seen at level I trauma centers.Design, Setting, and ParticipantsThis prospective longitudinal cohort study used data from Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) and included patients aged 17 years or older presenting at 18 US level I trauma center emergency departments or inpatient units within 24 hours of head injury, control individuals with orthopedic injury recruited …

Prognostication and withdrawal of care decisions in severe traumatic brain injury: a survey of the Seattle International Severe Traumatic Brain Injury Consensus Conference …

Authors

Buse Sarigul,R Bell,R Chesnut,Sergio Aguilera,Andras Buki,Giuseppe Citerio,D Cooper,R Diaz-Arrastia,Michael Diringer,Anthony Figaji,Guoyi Gao,Romer Geocadin,Jamshid Ghajar,O Harris,Alan Hoffer,P Hutchinson,Matthew Joseph,R Kitagawa,G Manley,Stephan Mayer,David Menon,Geert Meyfroidt,Daniel Michael,Mauro Oddo,D Okonkwo,M Patel,C Robertson,J Rosenfeld,A Rubiano,Juan Sahuquillo,Franco Servadei,Lori Shutter,Deborah Stein,Nino Stocchetti,Fabio Taccone,Shelly Timmons,Eve Tsai,J Ullman,P Vespa,Walter Videtta,David Wright,Christopher Zammit,Gregory Hawryluk

Journal

Journal of neurotrauma

Published Date

2023

Best practice guidelines have advanced severe traumatic brain injury (TBI) care, however, little currently informs goals of care decisions and processes despite their importance and frequency. Panelists from the Seattle International severe traumatic Brain Injury Consensus Conference (SIBICC) participated in a survey consisting of 24 questions. Questions queried use of prognostic calculators, variability in and responsibility for goals of care decisions, acceptability of neurological outcomes as well as putative means of improving decisions which may limit care. 97.6% of the 42 SIBICC panelists completed the survey. Responses were highly variable to most questions. Overall panelists reported infrequent use of prognostic calculators and observing variability in patient prognostication and goals of care decisions. They felt that it would be beneficial for physicians to improve consensus on what constitutes an acceptable neurological outcome as well as what chance of achieving that outcome is acceptable. Panelists felt that the public should help to define what constitutes a good outcome and expressed some support for a'nihilism guard'. Over 50% of panelists felt that if it was certain to be enduring, a vegetative state or lower severe disability would justify a withdrawal of care decision while 15% felt that upper severe disability justified such a decision. Whether conceptualizing an ideal or existing prognostic calculator to predict death or an unacceptable outcome, a 64-69% chance of a poor outcome on average was felt to justify treatment withdrawal. These results demonstrate important variability in goals of care decision making and a desire to reduce …

21 Associations Between Initial Injury Severity, Cerebral Metabolites, and the Local Connectome in Remote Mild-to-Moderate TBI

Authors

Abigail B Waters,Mark Britton,Claudia S Robertson,Richard Rubenstein,Amy K Wagner,Kevin Wang,Damon Lamb,John B Williamson

Journal

Journal of the International Neuropsychological Society

Published Date

2023/11

ObjectiveTo determine the association between in-vivo spectroscopy metabolite data, the local connectome, and markers of initial injury severity (I.e., history of loss of consciousness; LoC) in traumatic brain injury (TBI), in a heterogenous sample of Veterans and non-Veterans with a history of remote mild-to-moderate TBI (I.e., >6 months).Participants and MethodsParticipants with complete PRESS magnetic resonance spectroscopy (MRS) and diffusion weighted imaging (DWI) data (N = 41) were sampled from a larger multisite study of chronic mild-to-moderate TBI (Nmiid = 38; Nmoderate = 3; 54% with LoC; 46% with multiple TBI). The sample was predominantly male (76%) with ages ranging from 23-59 (M = 36.9, SD = 10.1), with 98% holding at least a high school degree (M = 14.5 years of education, SD = 2.4). Fully tissue-and-relaxation-corrected metabolite concentration estimates in the dorsal anterior cingulate …

Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study

Authors

Kevin K Wang,Jennifer C Munoz-Pareja,Lauren A Lautenslager,J Adrian Tyndall,Zhihui Yang,Maria R Kerrigan,Ramon Diaz-Arrastia,Frederick K Korley,David Okonkwo,Ava M Puccio,John K Yue,Sabrina R Taylor,Pratik Mukherjee,Esther L Yuh,Nancy R Temkin,Claudia S Robertson,Xiaoying Sun,Sonia Jain,Amy J Markowitz,Geoffrey T Manley,Opeolu Adeoye,Neeraj Badjatia,Kim Boase,Yelena Bodien,M Ross Bullock,Randall Chesnut,John D Corrigan,Karen Crawford,Sureyya Dikmen,Ann-Christine Duhaime,Richard Ellenbogen,V Ramana Feeser,Adam R Ferguson,Brandon Foreman,Raquel Gardner,Etienne Gaudette,Joseph Giacino,Luis Gonzalez,Shankar Gopinath,Rao Gullapalli,J Claude Hemphill,Gillian Hotz,Joel Kramer,Natalie Kreitzer,Harvey Levin,Chris Lindsell,Joan Machamer,Christopher Madden,Alastair Martin,Thomas McAllister,Michael McCrea,Randall Merchant,Lindsay Nelson,Laura Ngwenya,Eva Palacios,Daniel Perl,Miri Rabinowitz,Jonathan Rosand,Angelle Sander,Gabriella Satris,David Schnyer,Seth Seabury,Arthur Toga,Alex Valadka,Mary Vassar,Paul Vespa,Ross Zafonte

Journal

Advances in Biomarker Sciences and Technology

Published Date

2023/1/1

The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys® levels for identifying TBI patients with structural abnormalities on neuroimaging.The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Phase 1 Cohort, enrolled 1375 TBI patients (GCS 3–15) presenting to one of 18 US Level I trauma centers within 24 h of injury who had an admission head CT; blood samples were collected, along with 122 orthopedic and 209 healthy controls. The TBI cohort consisted of 810 CT-negative (CT-) and 549 CT-positive (CT+) subjects. Of the CT- subjects who had MRIs, 121 were MRI-positive (MRI+) and 333 were MRI-negative (MRI-). UCH-L1 POC showed best diagnostic performance for CT + versus CT-, 0–8 h post-injury with an AUC of 0 …

25 Associations between Diffusion Kurtosis Imaging, Tau, and Cognitive Outcomes in TBI

Authors

Robert D Claar,Aditi Venkatesh,Richard Rubenstein,Kevin Wang,Amy Wagner,Claudia Robertson,Erin Trifilio,John Williamson,Damon Lamb

Journal

Journal of the International Neuropsychological Society

Published Date

2023/11

ObjectiveDetermine associations between cognitive outcomes in remote TBI (i.e., at least 6 months post injury), a blood marker of neural degeneration (i.e., Tau), and diffusion kurtosis imaging (DKI) measures (e.g., mean or radial kurtosis). Because DKI imaging is sensitive to the environmental complexity of the imaged area, we sought to investigate regions known to be associated with the cognitive and emotional sequalae of TBI, such as the anterior thalamic radiations, uncinate fasciculus, and the corpus callosum.Participants and Methods41 individuals with mild-to-moderate TBI and a mean age(SD) of 36.1(10.4) years underwent DKI, a blood draw, and neuropsychological assessments. 23 healthy controls (HC) with a mean age(SD) of 35.2(15.2) years underwent the blood draw and assessments, but no imaging. Higher diffusion kurtosis indicates more restricted diffusion, possibly due to greater complexity …

9 Serum Neurofilament is Associated with Diffusion Kurtosis Imaging in Chronic Mild-Moderate Traumatic Brain Injury

Authors

Erin R Trifilio,Robert D Claar,Aditi Venkatesh,Sarah Bottari,David Barton,Claudia S Robertson,Richard Rubenstein,Amy K Wagner,Kevin KW Wang,Damon G Lamb,John B Williamson

Journal

Journal of the International Neuropsychological Society

Published Date

2023/11

ObjectiveTo determine the association between blood markers of white matter injury (e.g., serum neurofilament light and phosphorylated neurofilament heavy) and a novel neuroimaging technique measuring microstructural white matter changes (e.g., diffusion kurtosis imaging) in regions (e.g., anterior thalamic radiation and uncinate fasciculus) known to be impacted in traumatic brain injury (TBI) and associated with symptoms common in those with chronic TBI (e.g., sleep disruption, cognitive and emotional disinhibition) in a heterogeneous sample of Veterans and non-Veterans with a history of remote TBI (i.e., >6 months).Participants and MethodsParticipants with complete imaging and blood data (N=24) were sampled from a larger multisite study of chronic mild-moderate TBI. Participants ranged in age from young to middle-aged (mean age = 34.17, SD age = 10.96, range = 19-58) and primarily male (66.7 …

Integrating, harmonizing, and curating studies with high-frequency and hourly physiological data: Proof of concept from seven traumatic brain injury data sets

Authors

Ashraf Yaseen,Claudia Robertson,Jovany Cruz Navarro,Jingxiao Chen,Brian Heckler,Stacia M DeSantis,Nancy Temkin,Jason Barber,Brandon Foreman,Ramon Diaz-Arrastia,Randall Chesnut,Geoffrey T Manley,David W Wright,Mary Vassar,Adam R Ferguson,Amy J Markowitz,Jose-Miguel Yamal

Journal

Journal of neurotrauma

Published Date

2023/11/1

Research in severe traumatic brain injury (TBI) has historically been limited by studies with relatively small sample sizes that result in low power to detect small, yet clinically meaningful outcomes. Data sharing and integration from existing sources hold promise to yield larger more robust sample sizes that improve the potential signal and generalizability of important research questions. However, curation and harmonization of data of different types and of disparate provenance is challenging. We report our approach and experience integrating multiple TBI data sets containing collected physiological data, including both expected and unexpected challenges encountered in the integration process. Our harmonized data set included data on 1536 patients from the Citicoline Brain Injury Treatment Trial (COBRIT), Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a …

Prevalence of and risk factors for post-traumatic headache in civilian patients after mild traumatic brain injury: a TRACK-TBI study

Authors

Håkan Ashina,David W Dodick,Jason Barber,Nancy R Temkin,Catherine D Chong,Jennifer S Adler,Ken Shubin Stein,Todd J Schwedt,Geoffrey T Manley,Neeraj Badjatia,V Ramana Feeser,Shankar Gopinath,Ramesh Grandhi,C Dirk Keene,Ryan Kitagawa,Frederick K Korley,Christine Mac Donald,Christopher Madden,Pratik Mukherjee,Laura B Ngwenya,David Okonkwo,Claudia Robertson,Richard B Rodgers,David Schnyer,Sabrina R Taylor,Mary Vassar,John K Yue,Ross Zafonte

Journal

Mayo Clinic Proceedings

Published Date

2023/10/1

ObjectiveTo ascertain the prevalence of and risk factors for post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).Patients and MethodsA prospective, longitudinal, multicenter cohort study of patients with mTBI and orthopedic trauma controls who were enrolled from February 26, 2014, to August 8, 2018. The baseline assessment was conducted as soon as possible following evaluation at the emergency department. Follow-ups were scheduled at 2 weeks, 3 months, 6 months, and 12 months postinjury. Eligible patients with mTBI included those 18 years of age or older who presented to the emergency department within 24 hours of head injury warranting evaluation by noncontrast head computed tomography scan. Acute PTH was considered present when a patient reported a headache score of greater than or equal to 2 on the Rivermead Post-concussion Questionnaire at 2 weeks postinjury …

HMG-CoA reductase inhibitors for traumatic brain injury

Authors

Kalman Katlowitz,Shankar Gopinath,Jovany Cruz Navarro,Claudia Robertson

Published Date

2023/10/1

Traumatic brain injuries (TBIs) are associated with high morbidity and mortality due to both the original insult as well as the destructive biological response that follows. Medical management aims to slow or even halt secondary neurological injury while simultaneously laying the groundwork for recovery. Statins are one class of medications that is showing increased promise in the management of TBI. Used extensively in cardiovascular disease, these drugs were originally developed as competitive inhibitors within the cholesterol production pipeline. They are now used in diverse disease states due to their pleiotropic effects on other biological processes such as inflammation and angiogenesis. Preclinical studies, retrospective reviews, and randomized clinical trials have shown a variety of benefits in the management of TBI, but to date, no large-scale randomized clinical trial has been performed. Despite this …

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The h-index of Claudia Robertson has been 51 since 2020 and 98 in total.

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The articles with the titles of

Oxidized activated charcoal nanozymes: Synthesis, and optimization for in vitro and in vivo bioactivity for traumatic brain injury

Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients

Temporal Profiles of P-Tau, T-Tau, and P-Tau: Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to 6–12 Month …

Serial Measurements of Serum Glial Fibrillary Acidic Protein in Moderate-Severe Traumatic Brain Injury: Potential Utility in Providing Insights into Secondary Insults and Long …

Parallel CSF and serum temporal profile assessment of axonal injury biomarkers NF-L and pNF-H: Associations with patient outcome in moderate-severe traumatic brain injury

Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study

Clinical outcomes after traumatic brain injury and exposure to extracranial surgery: a TRACK-TBI Study

Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury

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are the top articles of Claudia Robertson at Baylor College of Medicine.

What are Claudia Robertson's research interests?

The research interests of Claudia Robertson are: traumatic brain injury

What is Claudia Robertson's total number of citations?

Claudia Robertson has 34,479 citations in total.

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