Alfonso De Simone
Imperial College London
H-index: 44
Europe-United Kingdom
Top articles of Alfonso De Simone
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates | Journal of the American Chemical Society | Serene W Chen Joseph D Barritt Roberta Cascella Alessandra Bigi Cristina Cecchi | 2024/4/3 |
Region-specific changes in gene expression are associated with cognitive deficits in the alpha-synuclein-induced model of Parkinson's disease: A transcriptomic profiling study | Experimental Neurology | Maria Francesca Manchinu Mauro Pala Maria Francesca Palmas Maria Antonietta Diana Andrea Maschio | 2024/2/1 |
Oligomers in Amyloid-Associated Diseases-Structural Properties and Toxicity | Frontiers in Molecular Biosciences | Neville Vassallo Sandrine Ongeri Alfonso De Simone | 2023/6/21 |
Metal interactions of α-synuclein probed by NMR amide-proton exchange | Frontiers in Chemistry | Mario Gonzalez-Garcia Giuliana Fusco Alfonso De Simone | 2023/5/2 |
Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo | BioRxiv | Sonia Donzelli Sinead A OSullivan Anne-Laure Mahul-Mellier Ayse Ulusoy Giuliana Fusco | 2023/3/25 |
α-Synuclein and biological membranes: the danger of loving too much | Silvia Mansueto Giuliana Fusco Alfonso De Simone | 2023 | |
MetalHawk: Enhanced Classification of Metal Coordination Geometries by Artificial Neural Networks | Journal of chemical information and modeling | Gianmattia Sgueglia Michail D Vrettas Marco Chino Alfonso De Simone Angela Lombardi | 2023/11/13 |
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy | Science Advances | Cristina Olivieri Geoffrey C Li Yingjie Wang Manu VS Caitlin Walker | 2022/7/29 |
Protein kinase R dependent phosphorylation of α-synuclein regulates its membrane binding and aggregation | PNAS nexus | Lasse Reimer Hjalte Gram Nanna Møller Jensen Cristine Betzer Li Yang | 2022/11 |
Plasticity of membrane binding by the central region of α-synuclein | Frontiers in molecular biosciences | Carlos Navarro-Paya Maximo Sanz-Hernandez Alfonso De Simone | 2022/6/15 |
The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes | Frontiers in Molecular Biosciences | Giuliana Fusco Francesco Bemporad Fabrizio Chiti Christopher M Dobson Alfonso De Simone | 2022/9/7 |
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors | bioRxiv | Súil Collins Liisa van Vliet Fabrice Gielen Matej Janeček Sara Wagner Valladolid | 2022/3/28 |
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat | Protein Science | Francesca Malagrinò Giuliana Fusco Valeria Pennacchietti Angelo Toto Caterina Nardella | 2022/9 |
A kink in DWORF helical structure controls the activation of the sarcoplasmic reticulum Ca2+-ATPase | Structure | U Venkateswara Reddy Daniel K Weber Songlin Wang Erik K Larsen Tata Gopinath | 2022/3/3 |
Local Backbone Geometry Plays a Critical Role in Determining Conformational Preferences of Amino Acid Residues in Proteins | Biomolecules | Nicole Balasco Luciana Esposito Alfonso De Simone Luigi Vitagliano | 2022/8/26 |
Thermal tuning of protein hydration in a hyperthermophilic enzyme | Frontiers in Molecular Biosciences | Giuliana Fusco Carmen Biancaniello Michail D Vrettas Alfonso De Simone | 2022/11/28 |
Repurposing Pomalidomide as a neuroprotective drug: Efficacy in an alpha-Synuclein-based model of Parkinson’s disease | Neurotherapeutics | Maria Francesca Palmas Anna Ena Chiara Burgaletto Maria Antonietta Casu Giuseppina Cantarella | 2022/1 |
The intranigral infusion of human-alpha synuclein oligomers induces a cognitive impairment in rats associated with changes in neuronal firing and neuroinflammation in the … | Cells | Maria Francesca Palmas Michela Etzi Augusta Pisanu Chiara Camoglio Claudia Sagheddu | 2022/8/24 |
Enhancing biomolecular simulations with hybrid potentials incorporating NMR data | Journal of Chemical Theory and Computation | Guowei Qi Michail D Vrettas Carmen Biancaniello Maximo Sanz-Hernandez Conor T Cafolla | 2022/11/17 |
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition | Nature communications | Wing K Man Bogachan Tahirbegi Michail D Vrettas Swapan Preet Liming Ying | 2021/2/10 |
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