Zhong-Yin Zhang

Zhong-Yin Zhang

Purdue University

H-index: 95

North America-United States

About Zhong-Yin Zhang

Zhong-Yin Zhang, With an exceptional h-index of 95 and a recent h-index of 40 (since 2020), a distinguished researcher at Purdue University, specializes in the field of Protein tyrosine phosphatases, cell signaling, chemical biology & drug discovery.

His recent articles reflect a diverse array of research interests and contributions to the field:

Natural product-inspired molecules for covalent inhibition of SHP2 tyrosine phosphatase

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Sesquiterpenoid analogs

Discovery of a selective TC-PTP degrader for cancer immunotherapy

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

Zhong-Yin Zhang Information

University

Position

___

Citations(all)

27237

Citations(since 2020)

6647

Cited By

22925

hIndex(all)

95

hIndex(since 2020)

40

i10Index(all)

263

i10Index(since 2020)

161

Email

University Profile Page

Google Scholar

Zhong-Yin Zhang Skills & Research Interests

Protein tyrosine phosphatases

cell signaling

chemical biology & drug discovery

Top articles of Zhong-Yin Zhang

Natural product-inspired molecules for covalent inhibition of SHP2 tyrosine phosphatase

Tetrahedron

2024/3/2

Zihan Qu
Zihan Qu

H-Index: 1

Zhong-Yin Zhang
Zhong-Yin Zhang

H-Index: 42

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Neuron

2023/1/18

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

Genes & Diseases

2023/1/1

Sesquiterpenoid analogs

2023/11/14

Discovery of a selective TC-PTP degrader for cancer immunotherapy

Chemical Science

2023/10/24

Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity

Molecules

2023/10

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

Nature Communications

2023/7/27

Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy

Angewandte Chemie International Edition

2023/5/22

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Autophagy

2023/5/4

Lymphoid-specific tyrosine phosphatase (LYP) inhibitors

2023/4/18

PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371

Blood

2023/1/19

High-throughput screening strategies for space-based radiation countermeasure discovery

2022/11/1

Yuhong Du
Yuhong Du

H-Index: 22

Haian Fu
Haian Fu

H-Index: 39

Zhong-Yin Zhang
Zhong-Yin Zhang

H-Index: 42

Structure-based design of active-site-directed, highly potent, selective, and orally bioavailable low-molecular-weight protein tyrosine phosphatase inhibitors

Journal of medicinal chemistry

2022/10/5

PTPN22: Structure, function, and developments in inhibitor discovery with applications for immunotherapy

2022/8/3

Jianping Lin
Jianping Lin

H-Index: 19

Zhong-Yin Zhang
Zhong-Yin Zhang

H-Index: 42

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Journal of Biological Chemistry

2022/7/1

Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells

STAR protocols

2022/6/17

Targeted Covalent Inhibition of Small CTD Phosphatase-1 to Promote the Degradation of REST Transcription Factor in Human Cells

J med chem

2022

N-aryl oxamic acids

2021/12/7

Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation

iScience

2021/11/19

Systemic inhibition of PTPN22 augments anticancer immunity

The Journal of Clinical Investigation

2021/9/1

See List of Professors in Zhong-Yin Zhang University(Purdue University)

Co-Authors

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