Yasien Sayed, PhD

Yasien Sayed, PhD

University of the Witwatersrand

H-index: 22

Africa-South Africa

About Yasien Sayed, PhD

Yasien Sayed, PhD, With an exceptional h-index of 22 and a recent h-index of 11 (since 2020), a distinguished researcher at University of the Witwatersrand, specializes in the field of Protein Biochemistry, Biophysics, Structural Biology, Computational Biology.

His recent articles reflect a diverse array of research interests and contributions to the field:

The crystal structure of the host-guest complex: N′-{5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-(2-oxo-1,3-diazinan-1 …

The crystal structure of N′-{5-[2-(2, 6-dimethylphenoxy) acetamido]-4-hydroxy-1, 6-diphenylhexan-2-yl}-3-methyl-2-(2-oxo-1, 3-diazinan-1-yl) butanamide hydrate

Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir

Biophysical characterization, crystallization, and solution of the first crystal structure of the 28 kDa-Schistosoma bovis glutathione transferase

Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Obtaining high yield recombinant Enterococcus faecium nicotinate nucleotide adenylyltransferase for X-ray crystallography and biophysical studies

HIV protease hinge region insertions at codon 38 affect enzyme kinetics, conformational stability and dynamics

Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE …

Yasien Sayed, PhD Information

University

Position

Professor

Citations(all)

1316

Citations(since 2020)

478

Cited By

1036

hIndex(all)

22

hIndex(since 2020)

11

i10Index(all)

36

i10Index(since 2020)

16

Email

University Profile Page

University of the Witwatersrand

Google Scholar

View Google Scholar Profile

Yasien Sayed, PhD Skills & Research Interests

Protein Biochemistry

Biophysics

Structural Biology

Computational Biology

Top articles of Yasien Sayed, PhD

Title

Journal

Author(s)

Publication Date

The crystal structure of the host-guest complex: N′-{5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-(2-oxo-1,3-diazinan-1 …

Zeitschrift für Kristallographie-New Crystal Structures

Tebogo ML Mokoto

Andreas Lemmerer

Yasien Sayed

Mark G Smith

2024/1/19

The crystal structure of N′-{5-[2-(2, 6-dimethylphenoxy) acetamido]-4-hydroxy-1, 6-diphenylhexan-2-yl}-3-methyl-2-(2-oxo-1, 3-diazinan-1-yl) butanamide hydrate

Zeitschrift für Kristallographie-New Crystal Structures

Tebogo ML Mokoto

Andreas Lemmerer

Yasien Sayed

Mark G Smith

2024/6/25

Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir

Current Research in Structural Biology

SV Sankaran

Sowmya R Krishnan

Yasien Sayed

M Michael Gromiha

2024/2/20

Biophysical characterization, crystallization, and solution of the first crystal structure of the 28 kDa-Schistosoma bovis glutathione transferase

Journal of Molecular Structure

Hattie Hope Makumbe

Ramesh Pandian

Akeel Valli

Yasien Sayed

Ikechukwu Achilonu

2024/2/15

Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Genes

Sankaran Venkatachalam

Nisha Murlidharan

Sowmya R Krishnan

C Ramakrishnan

Mpho Setshedi

...

2023/2/20

Obtaining high yield recombinant Enterococcus faecium nicotinate nucleotide adenylyltransferase for X-ray crystallography and biophysical studies

International Journal of Biological Macromolecules

Olamide Jeje

Ramesh Pandian

Yasien Sayed

Ikechukwu Achilonu

2023/10/1

HIV protease hinge region insertions at codon 38 affect enzyme kinetics, conformational stability and dynamics

The Protein Journal

Zaahida Sheik Ismail

Roland Worth

Salerwe Mosebi

Yasien Sayed

2023/10

Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE …

ACS omega

Weeraya Thongkum

Puttaporn Klayprasert

Natthawat Semakul

Jaroon Jakmunee

Watchara Kasinrerk

...

2023/5/12

The unusual architecture of RNA-dependent RNA polymerase (RdRp)’s catalytic chamber provides a potential strategy for combination therapy against COVID-19

Molecules

Kamel Metwally

Nader E Abo-Dya

Mohammed Issa Alahmdi

Maha Z Albalawi

Galal Yahya

...

2023/3/20

Synthesis, stereochemistry and in vitro STD NMR and in silico HIV-1 PR enzyme-binding potential of MBH-derived inhibitors

Journal of Molecular Structure

Matshawandile Tukulula

Idris A Olasupo

Grace C Mugumbate

Kevin A Lobb

Rosalyn Klein

...

2022/11/15

Non-active site mutations in the HIV protease: Diminished drug binding affinity is achieved through modulating the hydrophobic sliding mechanism

International Journal of Biological Macromolecules

Dean Sherry

Ramesh Pandian

Yasien Sayed

2022/9/30

SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and …

Frontiers in molecular biosciences

Houcemeddine Othman

Haifa Ben Messaoud

Oussema Khamessi

Hazem Ben-Mabrouk

Kais Ghedira

...

2022/2/14

Cantilever-centric mechanism of cooperative non-active site mutations in HIV protease: Implications for flap dynamics

Journal of Molecular Graphics and Modelling

Dean Sherry

Roland Worth

Zaahida Sheik Ismail

Yasien Sayed

2021/7/1

Elasticity-Associated Functionality and Inhibition of the HIV Protease

Dean Sherry

Roland Worth

Yasien Sayed

2021/8/6

Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2–P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach

Journal of Molecular Graphics and Modelling

Ikechukwu Achilonu

Emmanuel Amarachi Iwuchukwu

Okechinyere Juliet Achilonu

Manuel Antonio Fernandes

Yasien Sayed

2020/12/1

Synthesis, Characterization and Biological Activity of Some Dithiourea Derivatives.

Journal of Applied Sciences and Environmental Management

HF Babamale

A Lawal

OA Rajee

EA Oloyede

2016

Two‐Step Preparation of Highly Pure, Soluble HIV Protease from Inclusion Bodies Recombinantly Expressed in Escherichia coli

Current Protocols in Protein Science

Dean Sherry

Roland Worth

Yasien Sayed

2020/6

Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction

Future Journal of Pharmaceutical Sciences

Iten M Fawzy

Khairia M Youssef

Nasser SM Ismail

Joachim Gullbo

Khaled AM Abouzid

2015/6/1

See List of Professors in Yasien Sayed, PhD University(University of the Witwatersrand)