Xingui Liu

Xingui Liu

University of Florida

H-index: 15

North America-United States

About Xingui Liu

Xingui Liu, With an exceptional h-index of 15 and a recent h-index of 14 (since 2020), a distinguished researcher at University of Florida, specializes in the field of Medicinal chemistry, Drug discovery, Pharmaceutical Sciences, targeted protein degradation, PROTAC.

His recent articles reflect a diverse array of research interests and contributions to the field:

Design and optimization of piperlongumine analogs as potent senolytics

Therapeutic agents and methods of treatment

Proximity-based modalities for biology and medicine

Piperlongumine conjugates induce targeted protein degradation

DUB be good to me

Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood–brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model

Xingui Liu Information

University

Position

___

Citations(all)

1439

Citations(since 2020)

1367

Cited By

403

hIndex(all)

15

hIndex(since 2020)

14

i10Index(all)

17

i10Index(since 2020)

16

Email

University Profile Page

University of Florida

Google Scholar

View Google Scholar Profile

Xingui Liu Skills & Research Interests

Medicinal chemistry

Drug discovery

Pharmaceutical Sciences

targeted protein degradation

PROTAC

Top articles of Xingui Liu

Title

Journal

Author(s)

Publication Date

Design and optimization of piperlongumine analogs as potent senolytics

Bioorganic & Medicinal Chemistry Letters

Xuan Zhang

Yonghan He

Xingui Liu

Xin Zhang

Peizhong Shi

...

2024/1/15

Therapeutic agents and methods of treatment

2023/10/26

Proximity-based modalities for biology and medicine

Xingui Liu

Alessio Ciulli

2023/7/14

Piperlongumine conjugates induce targeted protein degradation

Cell Chemical Biology

Jing Pei

Yufeng Xiao

Xingui Liu

Wanyi Hu

Amin Sobh

...

2023/2/16

DUB be good to me

Nature Chemical Biology

Xingui Liu

Alessio Ciulli

2022/4

Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood–brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2

Journal of the American Chemical Society

Xingui Liu

Alexia F Kalogeropulou

Sofia Domingos

Nikolai Makukhin

Raja S Nirujogi

...

2022/8/25

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

Nature communications

Dongwen Lv

Pratik Pal

Xingui Liu

Yannan Jia

Dinesh Thummuri

...

2021/11/25

Mitigation of late cardiovascular effects of oxygen ion radiation by γ-tocotrienol in a mouse model

Life sciences in space research

Ashley S Nemec-Bakk

Vijayalakshmi Sridharan

Reid D Landes

Preeti Singh

Maohua Cao

...

2021/11/1

Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition

Journal of medicinal chemistry

Pratik Pal

Dinesh Thummuri

Dongwen Lv

Xingui Liu

Peiyi Zhang

...

2021/9/17

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

Yonghan He

Sajid Khan

Zhiguang Huo

Dongwen Lv

Xuan Zhang

...

2020/12

Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluorine‐Substituted δ‐Tocotrienol Derivative

ChemMedChem

Xingui Liu

Saikat Poddar

Lin Song

Howard Hendrickson

Xuan Zhang

...

2020/3/18

Compositions and methods for selectively depleting senescent cells

2020/9/1

Assays and technologies for developing proteolysis targeting chimera degraders

Xingui Liu

Xuan Zhang

Dongwen Lv

Yaxia Yuan

Guangrong Zheng

...

2020/3

PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

Peiyi Zhang

Xuan Zhang

Xingui Liu

Sajid Khan

Daohong Zhou

...

2020

Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production

Bioorganic & medicinal chemistry

Xingui Liu

Zhengya Gao

Qiang Fu

Lin Song

Peiyi Zhang

...

2020/6/1

Targeting anti-apoptotic BCL-2 family proteins for cancer treatment

Xuan Zhang

Xingui Liu

Daohong Zhou

Guangrong Zheng

2020/1

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

Nature communications

Yonghan He

Xuan Zhang

Jianhui Chang

Ha-Neui Kim

Peiyi Zhang

...

2020/4/24

A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β

Molecules

Satheesh Gujarathi

Maroof Khan Zafar

Xingui Liu

Robert L Eoff

Guangrong Zheng

2020/12/11

Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity

Dinesh Thummuri

Xingui Liu

Wanyi Hu

Peiyi Zhang

Sajid Khan

...

2020/4/15

See List of Professors in Xingui Liu University(University of Florida)

Co-Authors

H-index: 73
Martin Hauer-Jensen

Martin Hauer-Jensen

University of Arkansas for Medical Sciences

H-index: 66
Peter A. Crooks

Peter A. Crooks

University of Arkansas for Medical Sciences

H-index: 63
Daohong Zhou

Daohong Zhou

University of Florida

H-index: 46
Christopher R McCurdy

Christopher R McCurdy

University of Florida

H-index: 33
Guangrong Zheng

Guangrong Zheng

University of Florida

H-index: 33
Cesar Compadre

Cesar Compadre

University of Arkansas for Medical Sciences

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