Tsuyoshi Saitoh

About Tsuyoshi Saitoh

Tsuyoshi Saitoh, With an exceptional h-index of 20 and a recent h-index of 16 (since 2020), a distinguished researcher at University of Tsukuba, specializes in the field of Medicinal Chemistry, Bioluminescence, Electron transfer chemistry.

His recent articles reflect a diverse array of research interests and contributions to the field:

Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology

The delta opioid receptor agonist KNT‐127 relieves innate anxiety‐like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala

Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands

The present and future of synthetic orexin receptor agonists

Design and synthesis of orexin 1 receptor-selective agonists

Sulfonamide derivative or pharmaceutically acceptable acid-addition salt

Face validation and pharmacologic analysis of Sik3Sleepy mutant mouse as a possible model of idiopathic hypersomnia

Design and synthesis of novel orexin 2 receptor agonists with a 1, 3, 5‑trioxazatriquinane skeleton

Tsuyoshi Saitoh Information

University

Position

___

Citations(all)

1201

Citations(since 2020)

865

Cited By

681

hIndex(all)

20

hIndex(since 2020)

16

i10Index(all)

33

i10Index(since 2020)

25

Email

University Profile Page

Google Scholar

Tsuyoshi Saitoh Skills & Research Interests

Medicinal Chemistry

Bioluminescence

Electron transfer chemistry

Top articles of Tsuyoshi Saitoh

Title

Journal

Author(s)

Publication Date

Morphinan Evolution: The Impact of Advances in Biochemistry and Molecular Biology

Keita Kajino

Akihisa Tokuda

Tsuyoshi Saitoh

2024/4/1

The delta opioid receptor agonist KNT‐127 relieves innate anxiety‐like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala

Neuropsychopharmacology Reports

Ayako Kawaminami

Daisuke Yamada

Toshinori Yoshioka

Azumi Hatakeyama

Moeno Nishida

...

2024/3

Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands

Bioorganic & Medicinal Chemistry Letters

Kenta Maeda

Tomoya Sugai

Akihisa Tokuda

Keita Kajino

Tsuyoshi Saitoh

...

2024/2/1

The present and future of synthetic orexin receptor agonists

Tsuyoshi Saitoh

Takeshi Sakurai

2023/7/6

Design and synthesis of orexin 1 receptor-selective agonists

Journal of Medicinal Chemistry

Keita Iio

Kao Hashimoto

Yasuyuki Nagumo

Mao Amezawa

Taisei Hasegawa

...

2023/4/12

Sulfonamide derivative or pharmaceutically acceptable acid-addition salt

2023/6/13

Face validation and pharmacologic analysis of Sik3Sleepy mutant mouse as a possible model of idiopathic hypersomnia

European journal of pharmacology

Asmaa Elhosainy

Haruka Suzuki-Abe

Mahesh K Kaushik

Staci J Kim

Tsuyoshi Saitoh

...

2023/9/5

Design and synthesis of novel orexin 2 receptor agonists with a 1, 3, 5‑trioxazatriquinane skeleton

Bioorganic & Medicinal Chemistry Letters

Mao Amezawa

Naoshi Yamamoto

Yasuyuki Nagumo

Noriki Kutsumura

Yukiko Ishikawa

...

2023/2/15

Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton

Organic Letters

Kenta Maeda

Sayaka Ohrui

Akihisa Tokuda

Yasuyuki Nagumo

Naoshi Yamamoto

...

2023/5/8

Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice

Frontiers in Pharmacology

Yang Lin

Koustav Roy

Shuji Ioka

Rintaro Otani

Mao Amezawa

...

2023/4/19

Chemogenetic activation of G12 signaling enhances adipose tissue browning

Signal Transduction and Targeted Therapy

Yuki Ono

Ryo Ito

Kaito Arai

Gurdeep Singh

Tsuyoshi Saitoh

...

2023/8/21

Selective electro-oxidation of cumene utilizing a flow reactor equipped with diamond electrodes

Current Research in Green and Sustainable Chemistry

Shogo Nihongi

Riyako Matsuoka

Tsuyoshi Saitoh

Yasuaki Einaga

Takashi Yamamoto

2023/1/1

Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands

Bioorganic & Medicinal Chemistry Letters

Keita Iio

Noriki Kutsumura

Yasuyuki Nagumo

Tsuyoshi Saitoh

Akihisa Tokuda

...

2022/1/15

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

PloS one

Hikari Yamamoto

Yasuyuki Nagumo

Yukiko Ishikawa

Yoko Irukayama-Tomobe

Yukiko Namekawa

...

2022/7/22

Electro-Organic Synthesis

Takashi Yamamoto

Tsuyoshi Saitoh

2022/3/16

Discovery of novel orexin receptor antagonists using a 1, 3, 5-trioxazatriquinane bearing multiple effective residues (TriMER) library

European Journal of Medicinal Chemistry

Tsuyoshi Saitoh

Mao Amezawa

Jumpei Horiuchi

Yasuyuki Nagumo

Naoshi Yamamoto

...

2022/10/5

Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring

Bioorganic & Medicinal Chemistry Letters

Keita Iio

Tsuyoshi Saitoh

Ryuichiro Ohshita

Tsubasa Hino

Mao Amezawa

...

2022/3/15

Essential structure of orexin 1 receptor antagonist YNT-707: conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives

Bioorganic & Medicinal Chemistry Letters

Tsuyoshi Saitoh

Kazunori Seki

Ryo Nakajima

Naoshi Yamamoto

Noriki Kutsumura

...

2020/2/1

Electro-conversion of cumene into acetophenone using boron-doped diamond electrodes

Beilstein Journal of Organic Chemistry

Mana Kitano

Tsuyoshi Saitoh

Shigeru Nishiyama

Yasuaki Einaga

Takashi Yamamoto

2022/9/7

Effect of removal of the 14-hydroxy group on the affinity of the 4, 5-epoxymorphinan derivatives for orexin and opioid receptors

Bioorganic & Medicinal Chemistry Letters

Koki Katoh

Naoshi Yamamoto

Yukiko Ishikawa

Yoko Irukayama-Tomobe

Ryuji Tanimura

...

2022/3/1

See List of Professors in Tsuyoshi Saitoh University(University of Tsukuba)