TJ Ley

TJ Ley

Washington University in St. Louis

H-index: 109

North America-United States

About TJ Ley

TJ Ley, With an exceptional h-index of 109 and a recent h-index of 60 (since 2020), a distinguished researcher at Washington University in St. Louis, specializes in the field of Hematology, Oncology, Cancer Genomics.

His recent articles reflect a diverse array of research interests and contributions to the field:

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB:: MYH11 oncofusion protein

Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics

Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity

PML:: RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells

CBFB::MYH11 expression activates Trp53 in myeloid cells, which inhibits cell growth and sensitizes cells to cytarabine

Persistent molecular disease in adult patients with AML evaluated with whole-exome and targeted error-corrected DNA sequencing

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

TJ Ley Information

University

Position

Professor of Medicine and Genetics School of Medicine

Citations(all)

69163

Citations(since 2020)

22819

Cited By

55669

hIndex(all)

109

hIndex(since 2020)

60

i10Index(all)

239

i10Index(since 2020)

143

Email

University Profile Page

Washington University in St. Louis

Google Scholar

View Google Scholar Profile

TJ Ley Skills & Research Interests

Hematology

Oncology

Cancer Genomics

Top articles of TJ Ley

Title

Journal

Author(s)

Publication Date

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB:: MYH11 oncofusion protein

The Journal of Clinical Investigation

Ryan B Day

Julia A Hickman

Ziheng Xu

Casey DS Katerndahl

Francesca Ferraro

...

2024/2/15

Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics

Molecular & Cellular Proteomics

Robert W Sprung

Qiang Zhang

Michael H Kramer

Matthew C Christopher

Petra Erdmann-Gilmore

...

2024/2/1

Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity

Science Advances

Yang Li

Haley J Abel

Michelle Cai

Taylor A LaValle

Tiankai Yin

...

2024/1/31

PML:: RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells

Proceedings of the National Academy of Sciences

Casey DS Katerndahl

Olivia RS Rogers

Ryan B Day

Ziheng Xu

Nichole M Helton

...

2024/4/30

CBFB::MYH11 expression activates Trp53 in myeloid cells, which inhibits cell growth and sensitizes cells to cytarabine

Cancer Research

Ryan B Day

Julia A Hickman

Casey D Katerndahl

Sai Mukund Ramakrishnan

Christopher A Miller

...

2024/3/22

Persistent molecular disease in adult patients with AML evaluated with whole-exome and targeted error-corrected DNA sequencing

JCO Precision Oncology

Michael J Slade

Reza Ghasemi

Michelle O'Laughlin

Tasha Burton

Robert S Fulton

...

2023/4

Rapid and Accurate Remethylation of Dnmt3a Deficient Hematopoietic Cells with Restoration of DNMT3A Activity

Blood

Yang Li

Haley Abel

Michelle Cai

Taylor Lavalle

Tiankai Yin

...

2023/11/28

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Blood

Georgina L Ryland

Masayuki Umeda

Linda Holmfeldt

Sören Lehmann

Morten Krogh Herlin

...

2023/2/16

Overexpression of the Signaling Integrator Gab2 Accelerates AML Development in Mice with Dnmt3a R878Hand Npm1 cA Mutations

Blood

Michael H Kramer

Stephanie Richardson

Yang Li

Nichole Helton

Daniel George

...

2023/11/28

Genomic landscape of TP53-mutated myeloid malignancies

Blood Advances

Haley J Abel

Karolyn A Oetjen

Christopher A Miller

Sai M Ramakrishnan

Ryan B Day

...

2023/8/22

Methods and compositions for treatment of cancer

2023/7/11

Mechanisms of PML:: Rara and GATA2 Protein Interactions in Hematopoietic Cells

Blood

Casey Katerndahl

Olivia Rogers

Nichole Helton

Sai Mukund Ramakrishnan

Christopher A Miller

...

2023/11/28

Melanoma in a patient with DNMT3A overgrowth syndrome

Molecular Case Studies

David Y Chen

Leslie A Sutton

Sai Mukund Ramakrishnan

Eric J Duncavage

Sharon E Heath

...

2023/4/1

Assessment of T-Cell Receptor (TCR) Mediated T-Cell Activation in Acute Myeloid Leukemia at Diagnosis Has Implications for Risk Stratification and Response to Immune Checkpoint …

Blood

Nancy BJ Arthur

Agata Gruszczynska

Ma Xenia G Illagan

Michael Prinsen

Sharon E Heath

...

2023/11/28

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Iscience

Amanda M Smith

Angela M Verdoni

Haley J Abel

David Y Chen

Shamika Ketkar

...

2022/4/15

A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing (vol 10, 3660, 2019)

Nature communications

Allegra A Petti

Stephen R Williams

Christopher A Miller

Ian T Fiddes

Sridhar N Srivatsan

...

2019/8/14

The Protein Interactomes of CBFB-MYH11 and RUNX1-RUNX1T1 Suggest Different Mechanisms of Action for Initiating Acute Myeloid Leukemia

Blood

Ryan B Day

Julia Hickman

Ziheng Xu

Casey DS Katerndahl

Francesca Ferraro

...

2022/11/15

Tumor suppressor function of WT1 in acute promyelocytic leukemia

haematologica

Matthew J Christopher

Casey DS Katerndahl

Hayley R LeBlanc

Tyler T Elmendorf

Vaishali Basu

...

2022/1/1

Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells

Leukemia

Elisabeth R Wilson

Nichole M Helton

Sharon E Heath

Robert S Fulton

Jacqueline E Payton

...

2022/4

Decitabine salvage for TP53-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy

Haematologica

Francesca Ferraro

Agata Gruszczynska

Marianna B Ruzinova

Christopher A Miller

Mary Elizabeth Percival

...

2022/7/7

See List of Professors in TJ Ley University(Washington University in St. Louis)