Timothy J Egan
University of Cape Town
H-index: 53
Africa-South Africa
Top articles of Timothy J Egan
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration | European Journal of Medicinal Chemistry | Mziyanda Mbaba Taryn M Golding Reinner O Omondi Roxanne Mohunlal Timothy J Egan | 2024/4/16 |
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides | International Journal for Parasitology: Drugs and Drug Resistance | Alexa Redway Christina Spry Ainka Brown Ursula Wiedemann Imam Fathoni | 2024/4/3 |
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates | European Journal of Medicinal Chemistry | Amad Uddin Sonal Gupta Rumaisha Shoaib Babita Aneja Iram Irfan | 2024/1/15 |
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical … | ACS Infectious Diseases | John Okombo Malkeet Kumar Devasha Redhi Kathryn J Wicht Lubbe Wiesner | 2023/2/20 |
Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches | Scientific Reports | Leah Amod Roxanne Mohunlal Nicole Teixeira Timothy J Egan Kathryn J Wicht | 2023/2/14 |
The ratio of M1 to M2 microglia in the striatum determines the severity of L‐Dopa‐induced dyskinesias | Journal of Neurochemistry | Peggy Rentsch Timothy Egan Andrea Kuriakose Sandy Stayte Bryce Vissel | 2023/12 |
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse … | Journal of medicinal chemistry | Dickson Mambwe Constance M Korkor Amanda Mabhula Zama Ngqumba Cleavon Cloete | 2022/12/12 |
Rhenium (I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum | Journal of Inorganic Biochemistry | Sara Nasiri Sovari Taryn M Golding Mziyanda Mbaba Roxanne Mohunlal Timothy J Egan | 2022/9/1 |
Structural-activity relationship of metallo-aminoquines as next generation antimalarials | Mohammad Abid Shailja Singh Timothy J Egan Mukesh C Joshi | 2022/3/1 | |
THC shows activity against cultured Plasmodium falciparum | Bioorganic & Medicinal Chemistry Letters | Ana Carolina C de Sousa Jill M Combrinck Keletso Maepa Timothy J Egan | 2021/12/15 |
Molecular mechanism exploration of potent fluorinated PI3K inhibitors with a triazine scaffold: unveiling the unusual synergistic effect of pyridine-to-pyrimidine ring … | The Journal of Physical Chemistry B | Abdolkarim Farrokhzadeh Farideh Badichi Akher Timothy J Egan | 2021/9/2 |
Heme detoxification in the malaria parasite: A target for antimalarial drug development | Katherine A de Villiers Timothy J Egan | 2021/5/13 | |
Correction to “Identification of 2, 4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium … | Journal of Medicinal Chemistry | Andre Horatscheck Ana Andrijevic Aloysius T Nchinda Claire Le Manach Tanya Paquet | 2021/1/28 |
A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes | ACS infectious diseases | Roxanne Openshaw Keletso Maepa Stefan J Benjamin Lauren Wainwright Jill M Combrinck | 2021/1/12 |
Identification of 2, 4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model | Journal of medicinal chemistry | André Horatscheck Ana Andrijevic Aloysius T Nchinda Claire Le Manach Tanya Paquet | 2020/10/26 |
Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites | Scientific Reports | Ana Carolina C de Sousa Jill M Combrinck Keletso Maepa Timothy J Egan | 2020/2/25 |
Targeting the cannabinoid receptor CB2 in a mouse model of l-dopa induced dyskinesia | Neurobiology of disease | Peggy Rentsch Sandy Stayte Timothy Egan Ian Clark Bryce Vissel | 2020/2/1 |
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products | International Journal for Parasitology: Drugs and Drug Resistance | Phanankosi Moyo William Shamburger Mariëtte E van der Watt Janette Reader Ana Carolina C De Sousa | 2020/8/1 |
Intrinsic fluorescence properties of antimalarial pyrido [1, 2-a] benzimidazoles facilitate subcellular accumulation and mechanistic studies in the human malaria parasite … | Organic & biomolecular chemistry | Constance M Korkor Larnelle F Garnie Leah Amod Timothy J Egan Kelly Chibale | 2020 |
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway | Nature communications | Gregory M LaMonte Frances Rocamora Danushka S Marapana Nina F Gnädig Sabine Ottilie | 2020/4/14 |
