Thomas Durcan

Thomas Durcan

McGill University

H-index: 26

North America-Canada

About Thomas Durcan

Thomas Durcan, With an exceptional h-index of 26 and a recent h-index of 23 (since 2020), a distinguished researcher at McGill University, specializes in the field of stem cells, brain organoids, neurodegenerative disorders, assay development.

His recent articles reflect a diverse array of research interests and contributions to the field:

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

Cover Image, Volume 72, Issue 6

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

3D optoacoustic mesoscopy of neuromelanin in entire human midbrain organoids

Thomas Durcan Information

University

Position

The Neuro's Early Drug Discovery Unit (EDDU)

Citations(all)

15371

Citations(since 2020)

7673

Cited By

8657

hIndex(all)

26

hIndex(since 2020)

23

i10Index(all)

49

i10Index(since 2020)

43

Email

University Profile Page

Google Scholar

Thomas Durcan Skills & Research Interests

stem cells

brain organoids

neurodegenerative disorders

assay development

Top articles of Thomas Durcan

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins

bioRxiv

2024

14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation

bioRxiv

2024

Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924

bioRxiv

2024

Thomas Durcan
Thomas Durcan

H-Index: 14

The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases

2024/12

Cover Image, Volume 72, Issue 6

Glia

2024/6

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

Molecular Neurodegeneration

2024/4/5

3D optoacoustic mesoscopy of neuromelanin in entire human midbrain organoids

2024/3/13

Illumination of understudied ciliary kinases

2024/3/8

Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress

Proceedings of the National Academy of Sciences

2024/3/5

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

Communications Biology

2024/2/28

Homozygous ALS-linked mutations in TARDBP/TDP-43 lead to hypoactivity and synaptic abnormalities in human iPSC-derived motor neurons

iScience

2024/2/9

A small molecule drug, AVP6, rescues synaptic deficits in human iPSC-derived neurons across the mucopolysaccharidosis type III spectrum

Molecular Genetics and Metabolism

2024/2/1

Thomas Durcan
Thomas Durcan

H-Index: 14

Early nuclear phenotypes and reactive transformation in human iPSC-derived astrocytes from ALS patients with SOD1 mutations

bioRxiv

2023

Guy Rouleau
Guy Rouleau

H-Index: 89

Thomas Durcan
Thomas Durcan

H-Index: 14

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

bioRxiv

2023

Neuroanatomical and cognitive biomarkers of alpha‐synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms

Journal of Neurochemistry

2023/10/7

Elucidating the impact of CSF1R variants on microglia development and function using patient-derived IPSCS

Journal of the Neurological Sciences

2023/12/1

Thomas Durcan
Thomas Durcan

H-Index: 14

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disorders

bioRxiv

2023

The neuro genomics partnership: A new consortium dedicated to a fully open patient to patient (P2P) integrative R&D approach

Journal of the Neurological Sciences

2023/12/1

See List of Professors in Thomas Durcan University(McGill University)

Co-Authors

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