Stefan Kääb
Ludwig-Maximilians-Universität München
H-index: 86
Europe-Germany
Description
Stefan Kääb, With an exceptional h-index of 86 and a recent h-index of 61 (since 2020), a distinguished researcher at Ludwig-Maximilians-Universität München, specializes in the field of sudden cardiac death, atrial fibrillation, epidemiology, genetics, familial arrhythmia syndromes.
His recent articles reflect a diverse array of research interests and contributions to the field:
Clinical practice of continuous rhythm monitoring after embolic stroke of undetermined source
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure
Major in-hospital complications after catheter ablation of cardiac arrhythmias: individual case analysis of 43 031 procedures
Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs
Genomic risk scores, biomolecules, and clinical conditions to predict atrial fibrillation: time to integrate what we can measure
REACT DX registry: Real world REACTion to atrial high rate episodes detected in implantable cardioverter-defibrillator recipients with a DX lead
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
Professor Information
University | Ludwig-Maximilians-Universität München |
---|---|
Position | Professor of Medicine and Cardiology Department of Medicine 1 |
Citations(all) | 27286 |
Citations(since 2020) | 12795 |
Cited By | 19353 |
hIndex(all) | 86 |
hIndex(since 2020) | 61 |
i10Index(all) | 203 |
i10Index(since 2020) | 170 |
University Profile Page | Ludwig-Maximilians-Universität München |
Research & Interests List
sudden cardiac death
atrial fibrillation
epidemiology
genetics
familial arrhythmia syndromes
Top articles of Stefan Kääb
Clinical practice of continuous rhythm monitoring after embolic stroke of undetermined source
Aims Embolic stroke of undetermined source (ESUS) accounts for up to 20% of ischemic strokes annually. Undetected atrial fibrillation (AF) is one important potential underlying cause. For AF, oral anticoagulation has evolved as the most preferable means of secondary stroke prevention. To detect unrecognized paroxysmal AF, long-term ECG monitoring is required, and implantable cardiac monitors (ICM) appear most suitable. Yet, ICMs are particularly costly, implantation is invasive, and remote monitoring places a personnel burden on health care providers. Here, we use data from a large cohort of ESUS patients to systematically analyze the effort of ICM remote monitoring for AF diagnosis and the strain on health care providers. Methods and results From a prospective, single-center, observational ESUS registry, we analyzed all ICM-equipped patients post-ESUS (n = 172) between January 1st, 2018, and December 31st, 2019. Through January 2nd, 2023, 48 patients (27.9%) were diagnosed with AF by ICM remote monitoring. During follow-up, a total of 29,180 remote monitoring episodes were transmitted, of which 17,742 were alarms for AF. A systematic estimation of workload revealed that on average, 20.3 trained physician workhours are required to diagnose one patient with AF. Conclusion ICM remote monitoring is useful to diagnose AF in cohort of post-ESUS patients. However, the number of ICM alarms is high, even in a cohort at known high risk of AF and in whom AF detection is therapeutically consequential. Improved automated event classification, clear recommendations for ICM interrogation after AF diagnosis, and a careful …
Authors
Aenne Solvejg von Falkenhausen,Johannes Wischmann,Linus M Keidel,Antonia M Kellnar,Raffael Thaler,Korbinian Lackermair,Heidi L Estner,Günter Höglinger,Steffen Massberg,Stefan Kääb,Lars Kellert,Moritz F Sinner
Journal
Plos one
Published Date
2024/4/17
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to …
Authors
Dominik Linz,Jason G Andrade,Elena Arbelo,Giuseppe Boriani,Guenter Breithardt,A John Camm,Valeria Caso,Jens Cosedis Nielsen,Mirko De Melis,Tom De Potter,Wolfgang Dichtl,Søren Zoega Diederichsen,Dobromir Dobrev,Nicolas Doll,David Duncker,Elke Dworatzek,Lars Eckardt,Christoph Eisert,Larissa Fabritz,Michal Farkowski,David Filgueiras-Rama,Andreas Goette,Eduard Guasch,Guido Hack,Stéphane Hatem,Karl Georg Haeusler,Jeff S Healey,Hein Heidbuechel,Ziad Hijazi,Lucas H Hofmeister,Leif Hove-Madsen,Thomas Huebner,Stefan Kääb,Dipak Kotecha,Katarzyna Malaczynska-Rajpold,José Luis Merino,Andreas Metzner,Lluís Mont,Ghulam Andre Ng,Michael Oeff,Abdul Shokor Parwani,Helmut Puererfellner,Ursula Ravens,Michiel Rienstra,Prashanthan Sanders,Daniel Scherr,Renate Schnabel,Ulrich Schotten,Christian Sohns,Gerhard Steinbeck,Daniel Steven,Tobias Toennis,Stylianos Tzeis,Isabelle C van Gelder,Roderick H van Leerdam,Kevin Vernooy,Manish Wadhwa,Reza Wakili,Stephan Willems,Henning Witt,Stef Zeemering,Paulus Kirchhof
Journal
Europace
Published Date
2024/4
Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure
Background Atrial fibrillation (AF) is the most common arrhythmia and is associated with considerable morbidity and mortality. Ischaemic heart failure (IHF) remains one of the most common causes of AF in clinical practice. However, ischaemia‐mediated mechanisms leading to AF are still incompletely understood, and thus, current treatment approaches are limited. To improve our understanding of the pathophysiology, we studied a porcine IHF model. Methods In pigs, IHF was induced by balloon occlusion of the left anterior descending artery for 90 min. After 30 days of reperfusion, invasive haemodynamic measurements and electrophysiological studies were performed. Masson trichrome and immunofluorescence staining were conducted to assess interstitial fibrosis and myofibroblast activation in different heart regions. Results After 30 days of reperfusion, heart failure with significantly reduced ejection …
Authors
Zhihao Zhang,Julia Vlcek,Valerie Pauly,Nora Hesse,Julia Bauer,Kavi Raj Chataut,Florian Maderspacher,Lina Sophie Volz,Katharina Buchberger,Ruibing Xia,Bianca Hildebrand,Stefan Kääb,Dominik Schüttler,Philipp Tomsits,Sebastian Clauss
Journal
European Journal of Clinical Investigation
Published Date
2024/4
Major in-hospital complications after catheter ablation of cardiac arrhythmias: individual case analysis of 43 031 procedures
Aims In-hospital complications of catheter ablation for atrial fibrillation (AF), atrial flutter (AFL), and ventricular tachycardia (VT) may be overestimated by analyses of administrative data. Methods and results We determined the incidences of in-hospital mortality, major bleeding, and stroke around AF, AFL, and VT ablations in four German tertiary centres between 2005 and 2020. All cases were coded by the G-DRG- and OPS-systems. Uniform code search terms were applied defining both the types of ablations for AF, AFL, and VT and the occurrence of major adverse events including femoral vascular complications, iatrogenic tamponade, stroke, and in-hospital death. Importantly, all complications were individually reviewed based on patient-level source records. Overall, 43 031 ablations were analysed (30 361 AF; 9364 AFL; 3306 VT). The number of ablations/year more than …
Authors
Lars Eckardt,Florian Doldi,Omar Anwar,Nele Gessler,Katharina Scherschel,Ann-Kathrin Kahle,Aenne S von Falkenhausen,Raffael Thaler,Julian Wolfes,Andreas Metzner,Christian Meyer,Stephan Willems,Julia Köbe,Philipp Sebastian Lange,Gerrit Frommeyer,Karl-Heinz Kuck,Stefan Kääb,Gerhard Steinbeck,Moritz F Sinner
Journal
Europace
Published Date
2024/1
Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs
Background Periodic repolarization dynamics (PRD) is an electrocardiographic biomarker that captures repolarization instability in the low frequency spectrum and is believed to estimate the sympathetic effect on the ventricular myocardium. High PRD indicates an increased risk for postischemic sudden cardiac death (SCD). However, a direct link between PRD and proarrhythmogenic autonomic remodeling has not yet been shown. Methods and Results We investigated autonomic remodeling in pigs with myocardial infarction (MI)–related ischemic heart failure induced by balloon occlusion of the left anterior descending artery (n=17) compared with pigs without MI (n=11). Thirty days after MI, pigs demonstrated enhanced sympathetic innervation in the infarct area, border zone, and remote left ventricle paralleled by altered expression of autonomic marker genes/proteins. PRD was enhanced 30 days after MI …
Authors
Julia Bauer,Julia Vlcek,Valerie Pauly,Nora Hesse,Ruibing Xia,Li Mo,Aparna Sharma Chivukula,Hannes Villgrater,Marie Dressler,Bianca Hildebrand,Eckhard Wolf,Konstantinos D Rizas,Axel Bauer,Stefan Kääb,Philipp Tomsits,Dominik Schüttler,Sebastian Clauss
Journal
Journal of the American Heart Association
Published Date
2024/4/19
Genomic risk scores, biomolecules, and clinical conditions to predict atrial fibrillation: time to integrate what we can measure
The large individual patient data meta-analysis of four controlled clinical trials by Marston and colleagues demonstrates that elevated biomolecule concentrations (NT-proBNP, left box) double the risk of atrial fibrillation, precise diagnosis of cardiovascular conditions (middle box) triples the risk, and polygenic risk scores (right box) again double the risk of future incident atrial fibrillation. These effects are additive. Identification of patients at high risk for atrial fibrillation should include information from all three components.
Authors
Stefan Kääb,Hilma Holm,Paulus Kirchhof
Published Date
2023/1/14
REACT DX registry: Real world REACTion to atrial high rate episodes detected in implantable cardioverter-defibrillator recipients with a DX lead
BACKGROUND: Atrial fibrillation (AF) is associated with significant morbidity and is predicted by atrial high rate events. The early detection of AF is paramount to timely interventions to reduce the morbidity of AF. The DX ICD system combined with Home Monitoring R allows for continuous atrial rhythm monitoring without the need for a dedicated atrial lead. OBJECTIVE: To establish the reaction to and timing of reactions to the detection of atrial high rate episodes (AHRE).
Authors
Matthew O’Connor,Christof Kolb,Norbert Klein,Thomas Rauwolf,Stefan Kuster,Stefan Kaeaeb,Roland Richard Tilz,Dietmar Baensch,Hüseyin Ince,Roberto Belke,Tino Hauser,Katrin Rietsch,Jan F Kraemer,Niels Wessel,Carsten Lennerz
Journal
Technology and Health Care
Published Date
2023/1/1
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury (SCI) patients are protected from VTE. We aimed to identify mechanisms of immobility-associated VTE protection in a cross-species approach. Mass spectrometry–based proteomics revealed an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP47) as the most substantially reduced protein. HSP47 down-regulation or ablation attenuated immune cell activation and neutrophil extracellular trap formation, contributing to thromboprotection in bears, SCI patients, and mice. This cross-species conserved platelet signature may give rise to …
Authors
Manuela Thienel,Johannes B Müller-Reif,Zhe Zhang,Vincent Ehreiser,Judith Huth,Khrystyna Shchurovska,Badr Kilani,Lisa Schweizer,Philipp E Geyer,Maximilian Zwiebel,Julia Novotny,Enzo Lüsebrink,Gemma Little,Martin Orban,Leo Nicolai,Shaza El Nemr,Anna Titova,Michael Spannagl,Jonas Kindberg,Alina L Evans,Orpheus Mach,Matthias Vogel,Steffen Tiedt,Steffen Ormanns,Barbara Kessler,Anne Dueck,Andrea Friebe,Peter Godsk Jørgensen,Monir Majzoub-Altweck,Andreas Blutke,Amin Polzin,Konstantin Stark,Stefan Kääb,Doris Maier,Jonathan M Gibbins,Ulrich Limper,Ole Frobert,Matthias Mann,Steffen Massberg,Tobias Petzold
Journal
Science
Published Date
2023/4/14
Professor FAQs
What is Stefan Kääb's h-index at Ludwig-Maximilians-Universität München?
The h-index of Stefan Kääb has been 61 since 2020 and 86 in total.
What are Stefan Kääb's top articles?
The articles with the titles of
Clinical practice of continuous rhythm monitoring after embolic stroke of undetermined source
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure
Major in-hospital complications after catheter ablation of cardiac arrhythmias: individual case analysis of 43 031 procedures
Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs
Genomic risk scores, biomolecules, and clinical conditions to predict atrial fibrillation: time to integrate what we can measure
REACT DX registry: Real world REACTion to atrial high rate episodes detected in implantable cardioverter-defibrillator recipients with a DX lead
Immobility-associated thromboprotection is conserved across mammalian species from bear to human
...
are the top articles of Stefan Kääb at Ludwig-Maximilians-Universität München.
What are Stefan Kääb's research interests?
The research interests of Stefan Kääb are: sudden cardiac death, atrial fibrillation, epidemiology, genetics, familial arrhythmia syndromes
What is Stefan Kääb's total number of citations?
Stefan Kääb has 27,286 citations in total.