Sebastian Polak

About Sebastian Polak

Sebastian Polak, With an exceptional h-index of 24 and a recent h-index of 15 (since 2020), a distinguished researcher at Uniwersytet Jagiellonski, specializes in the field of cardiotoxicity prediction, safety pharmacology, PBPK, QSP.

His recent articles reflect a diverse array of research interests and contributions to the field:

How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study

In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled …

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application

Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets

Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests—How Does the Infotechnomics Compare …

A novel physiologically based pharmacokinetic model of rectal absorption, evaluated and verified using clinical data on 10 rectally administered drugs

Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper

A Rational approach to predicting immediate release formulation behavior in multiple gastric motility patterns: a combination of a biorelevant apparatus, design of experiments …

Sebastian Polak Information

University

Position

Jagiellonian University Medical College

Citations(all)

2250

Citations(since 2020)

1049

Cited By

1581

hIndex(all)

24

hIndex(since 2020)

15

i10Index(all)

52

i10Index(since 2020)

23

Email

University Profile Page

Google Scholar

Sebastian Polak Skills & Research Interests

cardiotoxicity prediction

safety pharmacology

PBPK

QSP

Top articles of Sebastian Polak

Title

Journal

Author(s)

Publication Date

How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study

Clinical Pharmacology & Therapeutics

Olha Shuklinova

Sibylle Neuhoff

Sebastian Polak

2024/4/26

In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled …

Molecular Pharmaceutics

Marcela Staniszewska

Daria Myslitska

Michał Romański

Sebastian Polak

Grzegorz Garbacz

...

2024/4/3

Development and verification of mechanistic vaginal absorption and metabolism model to predict systemic exposure after vaginal ring and gel application

British Journal of Clinical Pharmacology

Kanika Thakur

Krishna Chaitanya Telaprolu

Daniel Paterson

Farzaneh Salem

Sumit Arora

...

2024/3/7

Can 3D Printed Tablets Be Bioequivalent and How to Test It: A PBPK Model Based Virtual Bioequivalence Study for Ropinirole Modified Release Tablets

Pharmaceutics

Olha Shuklinova

Gabriela Wyszogrodzka-Gaweł

Ewelina Baran

Bartosz Lisowski

Barbara Wiśniowska

...

2024/2/9

Artificial Intelligence That Predicts Sensitizing Potential of Cosmetic Ingredients with Accuracy Comparable to Animal and In Vitro Tests—How Does the Infotechnomics Compare …

International Journal of Molecular Sciences

Jadwiga Kalicińska

Barbara Wiśniowska

Sebastian Polak

Radoslaw Spiewak

2023/4/6

A novel physiologically based pharmacokinetic model of rectal absorption, evaluated and verified using clinical data on 10 rectally administered drugs

International Journal of Pharmaceutics

Yuri Dancik

Naresh Mittapelly

Santosh K Puttrevu

Sebastian Polak

2023/8/25

Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper

Toxicology and Applied Pharmacology

Barbara Wiśniowska

Susanne Linke

Sebastian Polak

Zofia Bielecka

Andreas Luch

...

2023/1/15

A Rational approach to predicting immediate release formulation behavior in multiple gastric motility patterns: a combination of a biorelevant apparatus, design of experiments …

Pharmaceutics

Marcela Staniszewska

Michał Romański

Sebastian Polak

Grzegorz Garbacz

Justyna Dobosz

...

2023/7/31

Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling

Data in Brief

Barbara Wiśniowska

Susanne Linke

Sebastian Polak

Zofia Bielecka

Andreas Luch

...

2023/6/1

Report on the Virtual Workshop: A Quest for Biowaiver, Including Next Generation Dissolution Characterization and Modeling

Dissolution Technologies

Justyna Srebro

Andreas Abend

Nikoletta Fotaki

Grzegorz Garbacz

Vivian A Gray

...

2023/5/1

Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary

The AAPS Journal

Eleftheria Tsakalozou

Mohamed-Eslam F Mohamed

Sebastian Polak

Tycho Heimbach

2023/10/2

Mechanistic modeling of drug products applied to the skin: a workshop summary report

Eleftheria Tsakalozou

Khondoker Alam

Priyanka Ghosh

Jessica Spires

Sebastian Polak

...

2023/5

3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy: Are we there yet?

Gabriela Wyszogrodzka-Gaweł

Olha Shuklinova

Bartek Lisowski

Barbara Wiśniowska

Sebastian Polak

2023/10/1

Development and performance verification of the PBPK model for antazoline and its metabolite and its utilization for pharmacological hypotheses formulating

Pharmaceuticals

Barbara Wiśniowska

Joanna Giebułtowicz

Roman Piotrowski

Piotr Kułakowski

Sebastian Polak

2022/3/20

In vitro/in vivo translation of synergistic combination of MDM2 and MEK inhibitors in melanoma using PBPK/PD modelling: part II

International journal of molecular sciences

Jakub Witkowski

Sebastian Polak

Zbigniew Rogulski

Dariusz Pawelec

2022/10/8

An open-access data set of pig skin anatomy and physiology for modelling purposes

Database

Laura Krumpholz

James F Clarke

Sebastian Polak

Barbara Wiśniowska

2022/1/1

Modelling and simulation approaches to support formulation optimization, clinical development and regulatory assessment of the topically applied formulations–Nimesulide …

European Journal of Pharmaceutics and Biopharmaceutics

Naresh Mittapelly

Sebastian Polak

2022/9/1

Mechanistic modeling of in vitro skin permeation and extrapolation to in vivo for topically applied metronidazole drug products using a physiologically based pharmacokinetic model

Molecular Pharmaceutics

Sumit Arora

James Clarke

Eleftheria Tsakalozou

Priyanka Ghosh

Khondoker Alam

...

2022/8/15

A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological …

Frontiers in Pharmacology

JF Clarke

K Thakur

Sebastian Polak

2022/12/1

Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

CPT: Pharmacometrics & Systems Pharmacology

Nikunjkumar Patel

James F Clarke

Farzaneh Salem

Tariq Abdulla

Frederico Martins

...

2022/8

See List of Professors in Sebastian Polak University(Uniwersytet Jagiellonski)

Co-Authors

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