Robert J. Mallis

Robert J. Mallis

Harvard University

H-index: 19

North America-United States

About Robert J. Mallis

Robert J. Mallis, With an exceptional h-index of 19 and a recent h-index of 14 (since 2020), a distinguished researcher at Harvard University, specializes in the field of biochemistry, biophysics, immunology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT‐cell and T‐cell receptor protein

Atomistic basis for the differential load response by the γδ and the chimeric Vγδ-Cαβ T cell receptors

Correlating single-molecule interactions with T cell performance

Characterizing Biophysical Parameters of Single TCR-pMHC Interactions Using Optical Tweezers

Dynamic mechanism for the ligand discrimination by αβ T-cell receptor enhanced by mechanical load

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation

Parsing digital or analogue TCR performance through piconewton forces

Robert J. Mallis Information

University

Position

Dana Farber Cancer Institute

Citations(all)

2187

Citations(since 2020)

803

Cited By

1668

hIndex(all)

19

hIndex(since 2020)

14

i10Index(all)

24

i10Index(since 2020)

19

Email

University Profile Page

Google Scholar

Robert J. Mallis Skills & Research Interests

biochemistry

biophysics

immunology

Top articles of Robert J. Mallis

Title

Journal

Author(s)

Publication Date

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

Elife

Ana C Chang-Gonzalez

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

Wonmuk Hwang

2024/1/3

Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT‐cell and T‐cell receptor protein

Protein Science

Robert J Mallis

Jonathan J Lee

Arjen Van den Berg

Kristine N Brazin

Thibault Viennet

...

2024/4

Atomistic basis for the differential load response by the γδ and the chimeric Vγδ-Cαβ T cell receptors

Biophysical Journal

Sofiya B Bettencourt

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

Wonmuk Hwang

2024/2/8

Correlating single-molecule interactions with T cell performance

Biophysical Journal

Hannah M Stephens

Aoi Akitsu

Robert J Mallis

Wonmuk Hwang

Ellis L Reinherz

...

2024/2/8

Characterizing Biophysical Parameters of Single TCR-pMHC Interactions Using Optical Tweezers

Hannah M Stephens

Evan Kirkpatrick

Robert J Mallis

Ellis L Reinherz

Matthew J Lang

2023/4/28

Dynamic mechanism for the ligand discrimination by αβ T-cell receptor enhanced by mechanical load

Biophysical Journal

Ana C Chang-Gonzalez

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

Wonmuk Hwang

2023/2/10

Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation

Nature

Jonathan S Duke-Cohan

Aoi Akitsu

Robert J Mallis

Cameron M Messier

Patrick H Lizotte

...

2023/1/19

Parsing digital or analogue TCR performance through piconewton forces

bioRxiv

Aoi Akitsu

Eiji Kobayashi

Yinnian Feng

Hannah M Stephens

Kristine N Brazin

...

2023

Measuring αβ T-cell receptor-mediated mechanosensing using optical tweezers combined with fluorescence imaging

Hannah M Stephens

Kristine N Brazin

Robert J Mallis

Yinnian Feng

Debasis Banik

...

2022/9/6

Atomistic origin for catch bond formation in the preTCR-pMHC complex

Biophysical Journal

Wonmuk Hwang

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

2022/2/11

Molecular dynamics simulation study of the TCRγδ-CD1d-sulfatide complex

Biophysical Journal

Sofiya B Bettencourt

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

Wonmuk Hwang

2022/2/11

Load-dependent conformational behavior of the A6 TCR HLA-A2/Tax pMHC complex

Biophysical Journal

Ana C Chang-Gonzalez

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

Wonmuk Hwang

2022/2/11

Mechanical Response of the A6 TCR in Complex with PMHC with and without Load

Biophysical Journal

Ana C Chang-Gonzalez

Wonmuk Hwang

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

2021/2/12

Pre–T cell receptors topologically sample self-ligands during thymocyte β-selection

Science

Xiaolong Li

Réka Mizsei

Kemin Tan

Robert J Mallis

Jonathan S Duke-Cohan

...

2021/1/8

A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR–pMHC complexes

Journal of Biological Chemistry

Reka Mizsei

Xiaolong Li

Wan-Na Chen

Monika Szabo

Jia-Huai Wang

...

2021/1/1

Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

Proceedings of the National Academy of Sciences

Robert J Mallis

Jonathan S Duke-Cohan

Dibyendu Kumar Das

Aoi Akitsu

Adrienne M Luoma

...

2021/6/29

The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site

Proceedings of the National Academy of Sciences

Wonmuk Hwang

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

2020/9/1

Conformational Dynamics of the T-cell Receptor Chassis Coordinates CDR3 Loop Positioning during Mechanosensing of pMHC Ligands

Biophysical Journal

Wonmuk Hwang

Robert J Mallis

Matthew J Lang

Ellis L Reinherz

2020/2/7

See List of Professors in Robert J. Mallis University(Harvard University)

Co-Authors

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