Paulus Kirchhof
University of Birmingham
H-index: 125
Europe-United Kingdom
Description
Paulus Kirchhof, With an exceptional h-index of 125 and a recent h-index of 89 (since 2020), a distinguished researcher at University of Birmingham, specializes in the field of atrial fibrillation, sudden death, heart failure, cardiomyopathy, electrophysiology.
His recent articles reflect a diverse array of research interests and contributions to the field:
Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models
Left Atrial Volume: Head to Head Comparison of CMR and TTE-Data FBom the Prospective, Population-based Hamburg City Health Cohort Study
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction
Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international …
Overexpression of VEGFα as a biomarker of endothelial dysfunction in aortic tissue of α-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease
Repeat pulmonary vein isolation and anterior line ablation using a novel point-by-point pulsed-field ablation system
GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
Professor Information
University | University of Birmingham |
---|---|
Position | University Heart and Vascular Center UKE Hamburg Germany and Institute of |
Citations(all) | 239637 |
Citations(since 2020) | 104399 |
Cited By | 212513 |
hIndex(all) | 125 |
hIndex(since 2020) | 89 |
i10Index(all) | 439 |
i10Index(since 2020) | 354 |
University Profile Page | University of Birmingham |
Research & Interests List
atrial fibrillation
sudden death
heart failure
cardiomyopathy
electrophysiology
Top articles of Paulus Kirchhof
Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models
Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search PMC Full-Text Archive Search in PMC Advanced Search User Guide Journal List Sci Data v.11; 2024 PMC10796748 Other Formats PDF (618K) Actions Cite Collections Share Permalink Copy RESOURCES Similar articles Cited by other articles Links to NCBI Databases Journal List Sci Data v.11; 2024 PMC10796748 As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Logo of sdata Sci Data. 2024; 11: 93. Published online 2024 Jan 18. doi: 10.1038/s41597-024-02941-w …
Authors
Christopher O’Shea,James Winter,S Nashitha Kabir,Molly O’Reilly,Simon P Wells,Olivia Baines,Laura C Sommerfeld,Joao Correia,Ming Lei,Paulus Kirchhof,Andrew P Holmes,Larissa Fabritz,Kashif Rajpoot,Davor Pavlovic
Journal
Scientific Data
Published Date
2024
Left Atrial Volume: Head to Head Comparison of CMR and TTE-Data FBom the Prospective, Population-based Hamburg City Health Cohort Study
Background: The left atrial volume (LAV) is a crucial cardiac parameter in several clinical settings such as in atrial fibrillation or heart failure for the assessment of diastolic dysfunction and cardiac risk. Currently available LAV reference values were defined by 2d transthoracic echocardiography (2d-TTE). However, LAV measurements are routine part of CMR protocols, though data on the interchangeability of LAV values between CMR and 2d-TTE remain scarce.Methods: We performed CMR (3 T scanner MAGNETOM™ Skyra, Siemens Healthineers, Erlangen, Germany) and 2d-TTE in 2126 participants of the Hamburg City Health Study (HCHS), a population-based cohort study of the middle-aged population in Hamburg. LAV was assessed in TTE from the 4-and 2-chamber view by the method of disk summation. In CMR, LAV was also measured in cine images from the 2-and 4-chamber orientation, employing the …
Authors
Jan Niklas Albrecht,Jan-Per Wenzel,Betül Toprak,Elina Petersen,Julius Nikorowitsch,Ersin Cavus,Charlotte Jahnke,Katharina Alina Riedl,Enver Tahir,Raphael Twerenbold,Gerhard Adam,Stefan Blankenberg,Paulus Kirchhof,Gunnar Lund,Kai Muellerleile,Ulf Radunski
Journal
Journal of Cardiovascular Magnetic Resonance
Published Date
2024/3/1
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to …
Authors
Dominik Linz,Jason G Andrade,Elena Arbelo,Giuseppe Boriani,Guenter Breithardt,A John Camm,Valeria Caso,Jens Cosedis Nielsen,Mirko De Melis,Tom De Potter,Wolfgang Dichtl,Søren Zoega Diederichsen,Dobromir Dobrev,Nicolas Doll,David Duncker,Elke Dworatzek,Lars Eckardt,Christoph Eisert,Larissa Fabritz,Michal Farkowski,David Filgueiras-Rama,Andreas Goette,Eduard Guasch,Guido Hack,Stéphane Hatem,Karl Georg Haeusler,Jeff S Healey,Hein Heidbuechel,Ziad Hijazi,Lucas H Hofmeister,Leif Hove-Madsen,Thomas Huebner,Stefan Kääb,Dipak Kotecha,Katarzyna Malaczynska-Rajpold,José Luis Merino,Andreas Metzner,Lluís Mont,Ghulam Andre Ng,Michael Oeff,Abdul Shokor Parwani,Helmut Puererfellner,Ursula Ravens,Michiel Rienstra,Prashanthan Sanders,Daniel Scherr,Renate Schnabel,Ulrich Schotten,Christian Sohns,Gerhard Steinbeck,Daniel Steven,Tobias Toennis,Stylianos Tzeis,Isabelle C van Gelder,Roderick H van Leerdam,Kevin Vernooy,Manish Wadhwa,Reza Wakili,Stephan Willems,Henning Witt,Stef Zeemering,Paulus Kirchhof
Journal
Europace
Published Date
2024/4
Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction
Desmoglein-2 mutations are detected in 5–10% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Endurance training accelerates the development of the ARVC phenotype, leading to earlier arrhythmic events. Homozygous Dsg2 mutant mice develop a severe ARVC-like phenotype. The phenotype of heterozygous mutant (Dsg2mt/wt) or haploinsufficient (Dsg20/wt) mice is still not well understood. To assess the effects of age and endurance swim training, we studied cardiac morphology and function in sedentary one-year-old Dsg2mt/wt and Dsg20/wt mice and in young Dsg2mt/wt mice exposed to endurance swim training. Cardiac structure was only occasionally affected in aged Dsg20/wt and Dsg2mt/wt mice manifesting as small fibrotic foci and displacement of Connexin 43. Endurance swim training increased the right ventricular (RV) diameter and decreased RV function in Dsg2mt/wt mice but not in wild types. Dsg2mt/wt hearts showed increased ventricular activation times and pacing-induced ventricular arrhythmia without obvious fibrosis or inflammation. Preload-reducing therapy during training prevented RV enlargement and alleviated the electrophysiological phenotype. Taken together, endurance swim training induced features of ARVC in young adult Dsg2mt/wt mice. Prolonged ventricular activation times in the hearts of trained Dsg2mt/wt mice are therefore a potential mechanism for increased arrhythmia risk. Preload-reducing therapy prevented training-induced ARVC phenotype pointing to beneficial treatment options in human patients.
Authors
Larissa Fabritz,Lisa Fortmueller,Katja Gehmlich,Sebastian Kant,Marcel Kemper,Dana Kucerova,Fahima Syeda,Cornelius Faber,Rudolf E Leube,Paulus Kirchhof,Claudia A Krusche
Journal
Biomedicines
Published Date
2024/4/30
Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international …
Aims Veno-arterial extracorporeal membrane oxygenation therapy (VA-ECMO) restores circulation and tissue oxygenation in cardiogenic shock (CS) patients, but can also lead to complications. This study aimed to quantify VA-ECMO complications and analyse their association with overall survival as well as favourable neurological outcome (cerebral performance categories 1 + 2). Methods and results All-comer patients with CS treated with VA-ECMO were retrospectively enrolled from 16 centres in four countries (2005–2019). Neurological, bleeding, and ischaemic adverse events (AEs) were considered. From these, typical VA-ECMO complications were identified and analysed separately as device-related complications. n = 501. Overall, 118 were women (24%), median age was 56.0 years, median lactate was 8.1 mmol/L. Acute myocardial infarction caused CS in 289 …
Authors
Benedikt N Beer,Caroline Kellner,Alina Goßling,Jonas Sundermeyer,Lisa Besch,Angela Dettling,Paulus Kirchhof,Stefan Blankenberg,Alexander M Bernhardt,Stefan Brunner,Pascal Colson,Dennis Eckner,Derk Frank,Ingo Eitel,Norbert Frey,Matthias Eden,Tobias Graf,Danny Kupka,Ulf Landmesser,Nicolas Majunke,Octavian Maniuc,Sven Möbius-Winkler,David A Morrow,Marc Mourad,Curt Noel,Peter Nordbeck,Martin Orban,Federico Pappalardo,Sandeep M Patel,Matthias Pauschinger,Hermann Reichenspurner,P Christian Schulze,Robert HG Schwinger,Antonia Wechsler,Carsten Skurk,Holger Thiele,Anubodh S Varshney,Can Martin Sag,Jannis Krais,Dirk Westermann,Benedikt Schrage
Journal
European Heart Journal: Acute Cardiovascular Care
Published Date
2024/2
Overexpression of VEGFα as a biomarker of endothelial dysfunction in aortic tissue of α-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease
Introduction Fabry's disease is an X-linked lysosomal storage disorder caused by reduced activity of α-galactosidase A (GAL), leading to premature death on account of renal, cardiac, and vascular organ failure. Accumulation of the GAL substrate globotriaosylceramide (Gb3) in endothelial and smooth muscle cells is associated with early vascular cell damage, suggesting endothelial dysfunction as a driver of cardiorenal organ failure. Here, we studied the vascular expression of the key angiogenic factors, VEGFα and its antagonist angiostatin, in Fabry α-GAL-Tg/KO mice and determined circulating VEGFα and angiostatin serum levels in patients with Fabry’s disease and healthy controls. Methods Cryopreserved aortic vessels from six α-GAL-Tg/KO and six wild-type (WT) mice were obtained and VEGFα and angiostatin levels were determined by performing Western blot analysis. VEGFα expression was visualized by an immunohistochemical staining of paraffin aortic rings. In addition, VEGFα and angiostatin serum levels were measured by using an enzyme-linked immunosorbent assay in 48 patients with genetically verified Fabry's disease (50% male) and 22 healthy controls and correlated with disease severity markers such as lyso-Gb3, albuminuria, NTproBNP, high-sensitive troponin T (hsTNT), and myocardial wall thickness. Results It was found that there was a significant increase in VEGFα protein expression (1.66 ± 0.35 vs. 0.62 ± 0.16, p = 0.0009) and a decrease in angiostatin expression (0.024 ± 0.007 vs. 0.053 ± 0.02, p = 0.038) in aortic lysates from α-GAL-Tg/KO compared with that from WT mice. Immunohistochemical …
Authors
N Lund,H Wieboldt,L Fischer,N Muschol,F Braun,T Huber,D Sorriento,G Iaccarino,K Müllerleile,E Tahir,G Adam,P Kirchhof,L Fabritz,M Patten
Journal
Frontiers in Cardiovascular Medicine
Published Date
2024/2/5
Repeat pulmonary vein isolation and anterior line ablation using a novel point-by-point pulsed-field ablation system
BackgroundPulsed-field ablation (PFA) is a nonthermal energy source for ablation of cardiac arrhythmias. This study investigated the prospective outcomes of a novel PFA generator in conjunction with a commercially available, contact force-sensing, focal ablation catheter.ObjectiveThe purpose of this study was to assess the feasibility, safety, and lesion characteristics of point-by-point PFA in consecutive patients undergoing repeat ablation of atrial fibrillation (AF).MethodsThe study involved reisolation of pulmonary veins (PVs) with electrical reconnection and the creation of an anterior line (AL) in patients with anterior substrate or durable pulmonary vein isolation (PVI).ResultsIn 24 patients (46% female; mean age 67 ± 10 years; 67% persistent AF), successful reisolation of 27 of 27 reconnected PVs (100%) was performed. In 19 patients, AL ablation was performed, with bidirectional block in 16 (84%), median …
Authors
Jan-Per Wenzel,Marc D Lemoine,Laura Rottner,Ilaria My,Fabian Moser,Julius Obergassel,Moritz Nies,Jan Rieß,Djemail Ismaili,Julius Nikorowitsch,Feifan Ouyang,Paulus Kirchhof,Andreas Rillig,Andreas Metzner,Bruno Reissmann
Journal
Heart Rhythm
Published Date
2024/3/1
GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
Viral myocarditis is characterized by infiltration of mononuclear cells essential for virus elimination. GPR15 has been identified as a homing receptor for regulatory T cells in inflammatory intestine diseases, but its role in inflammatory heart diseases is still elusive. Here we show that GPR15 deficiency impairs coxsackievirus B3 elimination, leading to adverse cardiac remodeling and dysfunction. Delayed recruitment of regulatory T cells in GPR15-deficient mice was accompanied by prolonged persistence of cytotoxic and regulatory T cells. In addition, RNA sequencing revealed prolonged inflammatory response and altered chemotaxis in knockout mice. In line, we identified GPR15 and its ligand GPR15L as an important chemokine receptor–ligand pair for the recruitment of regulatory and cytotoxic T cells. In summary, the insufficient virus elimination might be caused by a delayed recruitment of T cells as well as …
Authors
Bastian Stoffers,Hanna Wolf,Lucas Bacmeister,Svenja Kupsch,Tamara Vico,Timoteo Marchini,Maria A Brehm,Isabell Yan,P Moritz Becher,Armin Ardeshirdavani,Felicitas Escher,Sangwon V Kim,Karin Klingel,Paulus Kirchhof,Stefan Blankenberg,Tanja Zeller,Dennis Wolf,Ingo Hilgendorf,Dirk Westermann,Diana Lindner
Journal
Nature Cardiovascular Research
Published Date
2024/1
Professor FAQs
What is Paulus Kirchhof's h-index at University of Birmingham?
The h-index of Paulus Kirchhof has been 89 since 2020 and 125 in total.
What are Paulus Kirchhof's top articles?
The articles with the titles of
Publisher Correction: High resolution optical mapping of cardiac electrophysiology in pre-clinical models
Left Atrial Volume: Head to Head Comparison of CMR and TTE-Data FBom the Prospective, Population-based Hamburg City Health Cohort Study
Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference
Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction
Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international …
Overexpression of VEGFα as a biomarker of endothelial dysfunction in aortic tissue of α-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease
Repeat pulmonary vein isolation and anterior line ablation using a novel point-by-point pulsed-field ablation system
GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
...
are the top articles of Paulus Kirchhof at University of Birmingham.
What are Paulus Kirchhof's research interests?
The research interests of Paulus Kirchhof are: atrial fibrillation, sudden death, heart failure, cardiomyopathy, electrophysiology
What is Paulus Kirchhof's total number of citations?
Paulus Kirchhof has 239,637 citations in total.