Patrick Sinn

Patrick Sinn

University of Iowa

H-index: 37

North America-United States

About Patrick Sinn

Patrick Sinn, With an exceptional h-index of 37 and a recent h-index of 22 (since 2020), a distinguished researcher at University of Iowa, specializes in the field of Gene Therapy, Cystic Fibrosis, Measles, Infectious Disease, Viral Vector Design.

His recent articles reflect a diverse array of research interests and contributions to the field:

High ionic strength vector formulations enhance gene transfer to airway epithelia

Compositions and methods for the treatment of cystic fibrosis

Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties

Representative measles virus infection requires appropriate airway epithelia culture conditions

Interferon-independent processes constrain measles virus cell-to-cell spread in primary human airway epithelial cells

CFTR-rich ionocytes mediate chloride absorption across airway epithelia

597 Adeno-associated virus capsid modification to improve tropism for airway epithelial progenitor cells

WNK inhibition increases surface liquid ph and host defense in cystic fibrosis airway epithelia

Patrick Sinn Information

University

Position

Associate Professor of Pediatrics

Citations(all)

5392

Citations(since 2020)

1945

Cited By

4281

hIndex(all)

37

hIndex(since 2020)

22

i10Index(all)

58

i10Index(since 2020)

42

Email

University Profile Page

University of Iowa

Google Scholar

View Google Scholar Profile

Patrick Sinn Skills & Research Interests

Gene Therapy

Cystic Fibrosis

Measles

Infectious Disease

Viral Vector Design

Top articles of Patrick Sinn

Title

Journal

Author(s)

Publication Date

High ionic strength vector formulations enhance gene transfer to airway epithelia

bioRxiv

Ashley L Cooney

Laura Marquez Loza

Kenan Najdawi

Christian Brommel

Paul B McCray Jr

...

2024

Compositions and methods for the treatment of cystic fibrosis

2023/6/8

Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties

Frontiers in genome editing

Ashley L Cooney

Christian M Brommel

Soumba Traore

Gregory A Newby

David R Liu

...

2023

Representative measles virus infection requires appropriate airway epithelia culture conditions

Journal of virology

Justin W Kaufman

Brajesh K Singh

Lorellin A Durnell

Patrick L Sinn

2023/10/31

Interferon-independent processes constrain measles virus cell-to-cell spread in primary human airway epithelial cells

Microbiology spectrum

Lorellin A Durnell

Camilla E Hippee

Roberto Cattaneo

Jennifer A Bartlett

Brajesh K Singh

...

2023/10/17

CFTR-rich ionocytes mediate chloride absorption across airway epithelia

The Journal of clinical investigation

Lei Lei

Soumba Traore

Guillermo S Romano Ibarra

Philip H Karp

Tayyab Rehman

...

2023/10/16

597 Adeno-associated virus capsid modification to improve tropism for airway epithelial progenitor cells

Journal of Cystic Fibrosis

A Cooney

C Brommel

P Sinn

2022/10/1

WNK inhibition increases surface liquid ph and host defense in cystic fibrosis airway epithelia

American journal of respiratory cell and molecular biology

Tayyab Rehman

Philip H Karp

Andrew L Thurman

Steven E Mather

Akansha Jain

...

2022/10

Gene therapy potential for genetic disorders of surfactant dysfunction

Ashley L Cooney

Jennifer A Wambach

Patrick L Sinn

Paul B McCray Jr

2022/1/14

Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy

Molecular Therapy-Methods & Clinical Development

Laura I Marquez Loza

Ashley L Cooney

Qian Dong

Christoph O Randak

Stefano Rivella

...

2021/6/11

610: Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

Journal of Cystic Fibrosis

S Traore

S Krishnamurthy

A Cooney

C Brommel

K Kulhankova

...

2021/11/1

403: Single-cell sequencing analyses of airway basal cell differentiation after lentiviral transduction

Journal of Cystic Fibrosis

A Cooney

A Thurman

P McCray

A Pezzulo

P Sinn

2021/11/1

Measles virus exits human airway epithelia via infectious center sloughing

bioRxiv

Camilla E Hippee

Brajesh K Singh

Andrew L Thurman

Ashley L Cooney

Alejandro A Pezzulo

...

2021/3/9

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

Nucleic acids research

Sateesh Krishnamurthy

Soumba Traore

Ashley L Cooney

Christian M Brommel

Katarina Kulhankova

...

2021/10/11

Lentiviral vectors transduce lung stem cells without disrupting plasticity

Molecular Therapy-Nucleic Acids

Ashley L Cooney

Andrew L Thurman

Paul B McCray

Alejandro A Pezzulo

Patrick L Sinn

2021/9/3

Measles virus exits human airway epithelia within dislodged metabolically active infectious centers

PLoS pathogens

Camilla E Hippee

Brajesh K Singh

Andrew L Thurman

Ashley L Cooney

Alejandro A Pezzulo

...

2021/8/12

Intratracheal aerosolization of viral vectors to newborn pig airways

BioTechniques

Ashley L Cooney

Patrick L Sinn

2020/1

Methods matter: standard production platforms for recombinant AAV produce chemically and functionally distinct vectors

Molecular therapy Methods & clinical development

Neil G Rumachik

Stacy A Malaker

Nicole Poweleit

Lucy H Maynard

Christopher M Adams

...

2020/9/11

Adeno-associated virus-based gene therapy for lifelong correction of genetic disease

Christian M Brommel

Ashley L Cooney

Patrick L Sinn

2020/9/1

Extracellular vesicle-mediated siRNA delivery, protein delivery, and CFTR complementation in well-differentiated human airway epithelial cells

Genes

Brajesh K Singh

Ashley L Cooney

Sateesh Krishnamurthy

Patrick L Sinn

2020/3/26

See List of Professors in Patrick Sinn University(University of Iowa)

Co-Authors

H-index: 115
Eric A. Hoffman

Eric A. Hoffman

University of Iowa

H-index: 101
Paul B. McCray, Jr., M.D.

Paul B. McCray, Jr., M.D.

University of Iowa

H-index: 81
Curt D. Sigmund

Curt D. Sigmund

Medical College of Wisconsin

H-index: 74
David Meyerholz

David Meyerholz

University of Iowa

H-index: 52
Gary W. Blissard

Gary W. Blissard

Cornell University

H-index: 47
hongpeng jia

hongpeng jia

Johns Hopkins University

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