Luc Brunsveld

Luc Brunsveld

Technische Universiteit Eindhoven

H-index: 60

Europe-Netherlands

About Luc Brunsveld

Luc Brunsveld, With an exceptional h-index of 60 and a recent h-index of 38 (since 2020), a distinguished researcher at Technische Universiteit Eindhoven, specializes in the field of chemical biology, protein-protein interactions, drug discovery, nuclear receptors, supramolecular chemistry.

His recent articles reflect a diverse array of research interests and contributions to the field:

14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

Quantification of the lung cancer tumor marker CYFRA 21-1 using protein precipitation, immunoaffinity bottom-up LC-MS/MS

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

Strengths and challenges in current lung cancer care: Timeliness and diagnostic procedures in six Dutch hospitals

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment

Luc Brunsveld Information

University

Position

Hoogleraar Chemische Biologie

Citations(all)

18178

Citations(since 2020)

6335

Cited By

14361

hIndex(all)

60

hIndex(since 2020)

38

i10Index(all)

156

i10Index(since 2020)

117

Email

University Profile Page

Technische Universiteit Eindhoven

Google Scholar

View Google Scholar Profile

Luc Brunsveld Skills & Research Interests

chemical biology

protein-protein interactions

drug discovery

nuclear receptors

supramolecular chemistry

Top articles of Luc Brunsveld

Title

Journal

Author(s)

Publication Date

14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation

ACS Chemical Neuroscience

Gobert Heesink

Maxime CM van den Oetelaar

Slav A Semerdzhiev

Christian Ottmann

Luc Brunsveld

...

2024/4/18

Estrogen Receptor alpha/14-3-3 molecular glues as alternative treatment strategy for endocrine resistant breast cancer

bioRxiv

Emira Visser

Maria Donaldson Collier

Joseph Siefert

Markella Konstantinidou

Susana Paul

...

2024

Quantification of the lung cancer tumor marker CYFRA 21-1 using protein precipitation, immunoaffinity bottom-up LC-MS/MS

Clinical Chemistry and Laboratory Medicine (CCLM)

Sylvia AAM Genet

Sebastian AH van den Wildenberg

Maarten AC Broeren

Joost LJ van Dongen

Luc Brunsveld

...

2024/3/25

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

bioRxiv

Liora S Katz

Emira J Visser

Kathrin F Plitzko

Marloes Pennings

Peter J Cossar

...

2024

Strengths and challenges in current lung cancer care: Timeliness and diagnostic procedures in six Dutch hospitals

Lung Cancer

Sylvia AAM Genet

Esther Visser

Maggy Youssef-El Soud

Huub NA Belderbos

Gerben Stege

...

2024/3/1

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

bioRxiv

Sofie J Desmet

Jonathan Thommis

Tineke Vanderhaeghen

Edmee MF Vandenboorn

Yunkun Li

...

2024

Functional Classification and Interaction Selectivity Landscape of the Human SH3 Domain Superfamily

Cells

Neda S Kazemein Jasemi

Mehrnaz Mehrabipour

Eva Magdalena Estirado

Luc Brunsveld

Radovan Dvorsky

...

2024/1/20

Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment

ChemBioChem

Qi Wu

Federica Centorrino

Xavier Guillory

Madita Wolter

Christian Ottmann

...

2024/1/2

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

ACS Central Science

Dyana N Kenanova

Emira J Visser

Johanna M Virta

Eline Sijbesma

Federica Centorrino

...

2023/4/18

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

Journal of Biological Chemistry

Bente A Somsen

Eline Sijbesma

Seppe Leysen

Karolina Honzejkova

Emira J Visser

...

2023/7/1

Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer

Lung Cancer

Esther Visser

Sylvia AAM Genet

Remco PPA de Kock

Ben EEM van den Borne

Maggy Youssef-El Soud

...

2023/4/1

Enzymatic Regulation of Protein–Protein Interactions in Artificial Cells

Advanced Materials

Thijs W van Veldhuisen

Wiggert J Altenburg

Madelief AM Verwiel

Lenne JM Lemmens

Alexander F Mason

...

2023/7

Reversible dual-covalent molecular locking of the 14-3-3/ERRγ protein–protein interaction as a molecular glue drug discovery approach

Journal of the American Chemical Society

Bente A Somsen

Rick JC Schellekens

Carlo JA Verhoef

Michelle R Arkin

Christian Ottmann

...

2023/3/16

377-OR: Stabilizing 14-3-3 and ChREBP Cytoplasmic Interaction to Rescue ß-Cells from Glucolipotoxicity

Diabetes

LIORA S KATZ

ISABELLE L TSE

EMIRA VISSER

SHARON BAUMEL-ALTERZON

MARKUS KAISER

...

2023/6/20

Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry

Chemical Science

Carlo JA Verhoef

Danielle F Kay

Lars van Dijck

Richard G Doveston

Luc Brunsveld

...

2023

IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization

Cell Chemical Biology

Blaž Andlovic

Geronimo Heilmann

Sabrina Ninck

Sebastian A Andrei

Federica Centorrino

...

2023/6/15

Linking Chemical Fragments," Gluing" Protein Complexes, Connecting across Cultures

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emira J Visser

Priyadarshini Jaishankar

Eline Sijbesma

Marloes AM Pennings

Edmee MF Vandenboorn

...

2023/12/21

Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium

RSC Chemical Biology

Nick HJ Geertjens

Pim J de Vink

Tim Wezeman

Albert J Markvoort

Luc Brunsveld

2023

Analysis of Neuron–Specific enolase isozymes in human serum using immunoaffinity purification and liquid chromatography–tandem mass spectrometry quantification

Journal of Chromatography B

Sylvia AAM Genet

Jur RE Wolfs

Chris BAK Vu

Madita Wolter

Maarten AC Broeren

...

2023/5/1

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

Journal of the American Chemical Society

Markella Konstantinidou

Emira J Visser

Edmee Vandenboorn

Sheng Chen

Priyadarshini Jaishankar

...

2023/9/7

See List of Professors in Luc Brunsveld University(Technische Universiteit Eindhoven)