Krishnaiah Maddeboina, PhD

Krishnaiah Maddeboina, PhD

University of Nebraska Medical Center

H-index: 24

North America-United States

About Krishnaiah Maddeboina, PhD

Krishnaiah Maddeboina, PhD, With an exceptional h-index of 24 and a recent h-index of 14 (since 2020), a distinguished researcher at University of Nebraska Medical Center, specializes in the field of Medicinal Chemistry/Synthetic Organic Chemistry and Multitargeted Drug Discovery.

His recent articles reflect a diverse array of research interests and contributions to the field:

Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139

Recent advances in multitarget-directed ligands via in silico drug discovery

Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

In silico design of novel multitarget small molecule inhibitor LCI139 for the treatment of PTEN-mutant endometrial carcinoma

LC–MS/MS method for the quantitation of a dual PI3K/BRD4 inhibitor SF2523 in mouse plasma: Application to plasma protein binding and metabolism studies

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model

Novel multitarget small molecule inhibitor LCI133 and synthetic lethality in endometrial carcinoma via CDK9/PI3K axis.

The Novel CDK9/CDK4/6/PI3K Triple Inhibitor LCI139 for the Treatment of MYC-Driven Mantle Cell Lymphoma

Krishnaiah Maddeboina, PhD Information

University

Position

Research Instructor College of Pharmacy

Citations(all)

1684

Citations(since 2020)

518

Cited By

1352

hIndex(all)

24

hIndex(since 2020)

14

i10Index(all)

35

i10Index(since 2020)

19

Email

University Profile Page

University of Nebraska Medical Center

Google Scholar

View Google Scholar Profile

Krishnaiah Maddeboina, PhD Skills & Research Interests

Medicinal Chemistry/Synthetic Organic Chemistry and Multitargeted Drug Discovery

Top articles of Krishnaiah Maddeboina, PhD

Title

Journal

Author(s)

Publication Date

Targeting metabolism in non-small cell lung cancer (NSCLC) with the novel multitarget small molecule PI3K-CDK4/6-CDK9 inhibitor LCI139

Cancer Research

Cody C McHale

Anna V Ivanina Foureau

Hailey L Dryden

Krishnaiah Maddeboina

Dhananjaya Pal

...

2024/3/22

Recent advances in multitarget-directed ligands via in silico drug discovery

Krishnaiah Maddeboina

Bharath Yada

Shikha Kumari

Cody McHale

Dhananjaya Pal

...

2024/1/26

Discovery of an Aldo-Keto reductase 1C3 (AKR1C3) degrader

Communications Chemistry

Angelica V Carmona

Shirisha Jonnalagadda

Alfie M Case

Krishnaiah Maddeboina

Sravan K Jonnalagadda

...

2024/4/29

In silico design of novel multitarget small molecule inhibitor LCI139 for the treatment of PTEN-mutant endometrial carcinoma

Cancer Research

Vaidehi Mujumdar

Ritchie Delara

Hailey Dryden

Dhananjaya Pal

Krishnaiah Maddeboina

...

2024/3/22

LC–MS/MS method for the quantitation of a dual PI3K/BRD4 inhibitor SF2523 in mouse plasma: Application to plasma protein binding and metabolism studies

Biomedical Chromatography

Veenu Bala

Yashpal S Chhonker

Guillermo A Morales

Krishnaiah Maddeboina

Dhananjaya Pal

...

2023/8

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model

Journal of Medicinal Chemistry

Krishnaiah Maddeboina

Sravan K Jonnalagadda

Ahmed Morsy

Ling Duan

Yashpal S Chhonker

...

2023/7/10

Novel multitarget small molecule inhibitor LCI133 and synthetic lethality in endometrial carcinoma via CDK9/PI3K axis.

Ritchie Delara

Dhananjaya Pal

Krishnaiah Maddeboina

R Wendel Naumann

Erin Crane

...

2023/6/1

The Novel CDK9/CDK4/6/PI3K Triple Inhibitor LCI139 for the Treatment of MYC-Driven Mantle Cell Lymphoma

Blood

Dhananjaya Pal

Page Mangum Arditti

Krishnaiah Maddeboina

Cody C McHale

Hsih-Te Yang

...

2023/11/28

Treatment of PTEN/PI3K co-mutated endometrial adenocarcinoma with multitarget small molecule inhibitors

Cancer Research

Ritchie Delara

Cody McHale

Dhananjaya Pal

Krishnaiah Maddeboina

R Wendel Naumann

...

2023/4/4

1425 The novel small molecule multitarget inhibitor LCI133 sensitizes endometrial carcinoma to TRAIL-mediated apoptosis

Cody C McHale

Ritchie Delara

Dhananjaya Pal

Krishnaiah Maddeboina

Hailey Dryden

...

2023/11/1

Treating endometrial adenocarcinoma using multitarget PI3K/BRD4/CDK4/6/9 small molecule inhibitors (2255)

Gynecologic Oncology

Ritchie Delara

Cody McHale

Dhananjaya Pal

Krishnaiah Maddeboina

R Wendel Naumann

...

2023/9/1

Functionalized Allopurinols Targeting Amyloid-Binding Alcohol Dehydrogenase Rescue Aβ-Induced Mitochondrial Dysfunction

ACS Chem Neurosci.

Trippier PC. Morsy A

Maddeboina K

Gao J

Wang H

Valdez J

...

2022/7/8

Discovery of (E)-3-(3-((2-Cyano-4′-dimethylaminobiphenyl-4-ylmethyl)cyclohexanecarbonylamino)-5-fluorophenyl)acrylic Acid Methyl Ester, an Intestine-Specific …

Journal of Medicinal Chemistry

Soyeon Shim

Maddeboina Krishnaiah

Madhusudana Reddy Sankham

Inha Kim

Yoseob Lee

...

2022/7/7

A-Review-on-the-Catalytic-Applications-of-Polyaniline-Supported-Palladium (Pdcommat; PANI)-in-C–C-Coupling-Reactions

Bandameeda R Naidu

Krishnaiah Maddeboina

2022/7/1

Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma.

Molecular Biomedicine

Tatiana G Kutateladze Kendra R Vann

Dhananjaya Pal

Audrey L Smith

Namood-E Sahar

Maddeboina Krishnaiah

...

2022/1/15

Pivotal role of nitrogen heterocycles in Alzheimer’s disease drug discovery

Shikha Kumari

Krishnaiah Maddeboina

Rinda Devi Bachu

Sai HS Boddu

Paul C Trippier

...

2022/10/1

The Novel Multitarget Small-Molecule Inhibitor SRX3177 Overcomes Ibrutinib Resistance in Mantle Cell Lymphoma

Blood

Dhananjaya Pal

Cody C McHale

Samon Benrashid

Poornima Gourabathini

Krishnaiah Maddeboina

...

2021/11/23

Control of Peptide Amphiphile Supramolecular Nanostructures by Isosteric Replacements

Biomacromolecules

Huihua Xing

Stacey M Chin

Venkata Reddy Udumula

Maddeboina Krishnaiah

Nathalia Rodrigues de Almeida

...

2021/7/22

Protecting groups in peptide synthesis

Peptide Synthesis: Methods and Protocols

Martin Conda-Sheridan

Maddeboina Krishnaiah

2020

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