Klaus Okkenhaug
University of Cambridge
H-index: 66
Europe-United Kingdom
Top articles of Klaus Okkenhaug
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development | bioRxiv | Christina JF Courreges Elizabeth CM Davenport Benoit Bilanges Elena Rebollo-Gomez Jens Hukelmann | 2024 |
An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration | bioRxiv | Philippe Dehio Céline Michard Juan Carlos Yam-Puc Adrià-Arnau Martí i Líndez Lucien Fabre | 2024 |
Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion | Kristoffer H Johansen Dominic P Golec Klaus Okkenhaug Pamela L Schwartzberg | 2023/10/17 | |
The Toll-like receptor 4 pathway modulates response to anti-PD-1 therapy | The Journal of Immunology | Sarah K Whiteside Benjamin S Beresford-Jones Puspendu Sadar Paula Kuo Wangmingyu Xia | 2023/5/1 |
An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of activated PI3 kinase delta syndrome | Pulmonary pharmacology & therapeutics | Malcolm Begg Augustin Amour Emily Jarvis Teresa Tang Sara Santos Franco | 2023/4/1 |
Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion | Science immunology | Sarah K Whiteside Francis M Grant Giorgia Alvisi James Clarke Leqi Tang | 2023/12/15 |
Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance | bioRxiv | Munetomo Takahashi Tsz Y So Kate Williamson Zhaleh Hosseini Katarzyna Kania | 2023/3/20 |
Tetherin antagonism by SARS‐CoV‐2 ORF3a and spike protein enhances virus release | EMBO reports | Hazel Stewart Roberta Palmulli Kristoffer H Johansen Naomi McGovern Ola M Shehata | 2023/12/6 |
Tissue-resident B cells orchestrate macrophage polarisation and function | Nature communications | Ondrej Suchanek John R Ferdinand Zewen K Tuong Sathi Wijeyesinghe Anita Chandra | 2023/11/4 |
Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs | Nature | Simon Eschweiler Ciro Ramírez-Suástegui Yingcong Li Emma King Lindsey Chudley | 2022/5/26 |
BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis | Journal of Experimental Medicine | Charlotte J Imianowski Sarah K Whiteside Teresa Lozano Alexander C Evans Jayme D Benson | 2022/9/30 |
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells | Science signaling | Kristoffer H Johansen Dominic P Golec Bonnie Huang Chung Park Julie H Thomsen | 2022/7/19 |
How to resist PI3Kδ inhibition: activate MAPK! | Blood, The Journal of the American Society of Hematology | Klaus Okkenhaug | 2021/7/8 |
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells | Frontiers in Immunology | Daisy H Luff Katarzyna Wojdyla David Oxley Tamara Chessa Kevin Hudson | 2021/3/8 |
Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model | Brain, behavior, & immunity-health | Ines Serra Olivia R Manusama Fabian MP Kaiser Izi Izumi Floriano Lucas Wahl | 2021/12/1 |
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function | Immunology | Sarah K Whiteside Francis M Grant David S Gyori Alberto G Conti Charlotte J Imianowski | 2021/5/9 |
PI3K inhibitors are finally coming of age | Bart Vanhaesebroeck Matthew WD Perry Jennifer R Brown Fabrice André Klaus Okkenhaug | 2021/10 | |
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection | Blood advances | Chiara Pantarelli Dingxin Pan Stephen Chetwynd Anne-Katrien Stark Kirsti Hornigold | 2021/8/24 |
PI3K in T cell adhesion and trafficking | Kristoffer H Johansen Dominic P Golec Julie H Thomsen Pamela L Schwartzberg Klaus Okkenhaug | 2021/8/6 | |
BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression | Journal of Experimental Medicine | Francis M Grant Jie Yang Rabab Nasrallah James Clarke Firas Sadiyah | 2020/9/7 |
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