John M. Pascal
Université de Montréal
H-index: 47
North America-Canada
Top articles of John M. Pascal
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks | Biochemical Journal | Uday Kiran Velagapudi Élise Rouleau-Turcotte Ramya Billur Xuwei Shao Manisha Patil | 2024/3/13 |
A PARP2-specific active site α-helix melts upon DNA damage-induced enzymatic activation | Biophysical Journal | Emily S Smith Ramya Billur Marie-France Langelier John Pascal Ben E Black | 2024/2/8 |
ADP-ribose contributions to genome stability, and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification | Élise Rouleau-Turcotte John M Pascal | 2023/10/28 | |
PARP–nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance | John M Pascal | 2023/8/1 | |
Clinical PARP inhibitors allosterically induce PARP2 retention on DNA | Science Advances | Marie-France Langelier Xiaohui Lin Shan Zha John M Pascal | 2023/3/24 |
PARP1 associates with R-loops to promote their resolution and genome stability | Nucleic Acids Research | Natalie Laspata Parminder Kaur Sofiane Yacine Mersaoui Daniela Muoio Zhiyan Silvia Liu | 2023/3/21 |
Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP | Nucleic Acids Research | Léonie Frigon John M Pascal | 2023/12/11 |
A two-step mechanism governing PARP1-DNA retention by PARP inhibitors | Science advances | Huijun Xue Amit Bhardwaj Yandong Yin Carel Fijen Anastasiya Ephstein | 2022/9/7 |
ADP-ribosyltransferases, an update on function and nomenclature. | The Federation of European Biochemical Societies (FEBS) Journal | Ted Dawson Valina Dawson Sebastian Deindl Anthony Fehr Karla Feijs | 2022/12/1 |
Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery | Molecular cell | Élise Rouleau-Turcotte Dragomir B Krastev Stephen J Pettitt Christopher J Lord John M Pascal | 2022/8/18 |
ADP‐ribosyltransferases, an update on function and nomenclature | The FEBS journal | Bernhard Lüscher Ivan Ahel Matthias Altmeyer Alan Ashworth Peter Bai | 2022/12 |
Human PARP1 facilitates transcription through a nucleosome and histone displacement by Pol II in vitro | International Journal of Molecular Sciences | Elena Y Kotova Fu-Kai Hsieh Han-Wen Chang Natalia V Maluchenko Marie-France Langelier | 2022/6/26 |
Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly (ADP-ribose) | Cell reports | Jijin RA Kuttiyatveetil Heddy Soufari Morgan Dasovich Isabel R Uribe Manija Mirhasan | 2022/10/25 |
Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cells | DNA Damage Responses | Ishtiaque Rashid Miaw-Sheue Tsai Alan E Tomkinson | 2022/2 |
Unorthodox PCNA binding by chromatin assembly factor 1 | International Journal of Molecular Sciences | Amogh Gopinathan Nair Nick Rabas Sara Lejon Caleb Homiski Michael J Osborne | 2022/9/21 |
Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase | Structure | Aleksandr Sverzhinsky Alan E Tomkinson John M Pascal | 2022/3/3 |
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM | bioRxiv | Nicholas CK Valerie Kumar Sanjiv Oliver Mortusewicz Si Min Zhang Azita Rasti | 2022/9/19 |
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors | Cell Chemical Biology | Moriah R Arnold Marie-France Langelier Jessica Gartrell Ilsa T Kirby Daniel J Sanderson | 2022/12/15 |
CARM1 regulates replication fork speed and stress response by stimulating PARP1 | Molecular cell | Marie-Michelle Genois Jean-Philippe Gagné Takaaki Yasuhara Jessica Jackson Sneha Saxena | 2021/2/18 |
Mechanisms of nucleosome reorganization by PARP1 | International Journal of Molecular Sciences | Natalya V Maluchenko Dmitry K Nilov Sergey V Pushkarev Elena Y Kotova Nadezhda S Gerasimova | 2021/11/9 |
