John Karanicolas

John Karanicolas

Temple University

H-index: 36

North America-United States

About John Karanicolas

John Karanicolas, With an exceptional h-index of 36 and a recent h-index of 25 (since 2020), a distinguished researcher at Temple University, specializes in the field of Designing small-molecule modulators of protein activity using computational and biochemical approaches.

His recent articles reflect a diverse array of research interests and contributions to the field:

Germline p53 R181 variants and DNA binding cooperativity in tumorigenesis

PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

Novel substrate prediction for the TAM family of RTKs using phosphoproteomics and structure-based modeling

Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

Poor Generalization by Current Deep Learning Models for Predicting Binding Affinities of Kinase Inhibitors

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

John Karanicolas Information

University

Position

Molecular Therapeutics Group, Fox Chase Cancer Center

Citations(all)

8520

Citations(since 2020)

4174

Cited By

5854

hIndex(all)

36

hIndex(since 2020)

25

i10Index(all)

51

i10Index(since 2020)

45

Email

University Profile Page

Google Scholar

John Karanicolas Skills & Research Interests

Designing small-molecule modulators of protein activity using computational and biochemical approaches

Top articles of John Karanicolas

Germline p53 R181 variants and DNA binding cooperativity in tumorigenesis

Cancer Research

2024/3/22

Gregory Kelly
Gregory Kelly

H-Index: 30

John Karanicolas
John Karanicolas

H-Index: 24

PPIscreenML: Structure-based screening for protein-protein interactions using AlphaFold

bioRxiv

2024

John Karanicolas
John Karanicolas

H-Index: 24

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

bioRxiv

2023/1/10

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

bioRxiv

2023

Novel substrate prediction for the TAM family of RTKs using phosphoproteomics and structure-based modeling

ACS Chemical Biology

2023/12/30

John Karanicolas
John Karanicolas

H-Index: 24

Secreted folate receptor γ drives fibrogenesis in metabolic dysfunction–associated steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

Science Translational Medicine

2023/9/27

Poor Generalization by Current Deep Learning Models for Predicting Binding Affinities of Kinase Inhibitors

bioRxiv

2023/9/6

John Karanicolas
John Karanicolas

H-Index: 24

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Cancer discovery

2023/7/7

NSD1/2 histone methyltransferases regulate cell growth in HPV-negative head and neck squamous cell carcinoma (HNSCC)

Cancer Research

2023/4/4

Defining the function of tumor suppressor p53 arginine 181 residue in tumorigenesis

Cancer Research

2023/4/4

Gregory Kelly
Gregory Kelly

H-Index: 30

John Karanicolas
John Karanicolas

H-Index: 24

MSI2 regulates DNA damage response signaling and tumor progression in murine NSCLC

Cancer Research

2023/4/4

Computational Modeling of PROTAC Ternary Complexes and Linker Design

Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications

2023/1/24

John Karanicolas
John Karanicolas

H-Index: 24

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

bioRxiv

2022/7/22

NSD histone methyltransferases drive cell proliferation in HPV-negative head and neck squamous cell carcinoma (HNSCC)

Cancer Research

2022/6/15

Compositions and methods for modulation of antibody activity

2022/6/9

Correction to “Target-Based Design of Promysalin Analogs Identifies a New Putative Binding Cleft in Succinate Dehydrogenase”

ACS Infectious Diseases

2022/6/6

John Karanicolas
John Karanicolas

H-Index: 24

The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors

2022/6

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

NAR cancer

2022/6/1

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP)

International Journal of Molecular Sciences

2022/3/16

See List of Professors in John Karanicolas University(Temple University)