James Spudich

James Spudich

Stanford University

H-index: 109

North America-United States

About James Spudich

James Spudich, With an exceptional h-index of 109 and a recent h-index of 45 (since 2020), a distinguished researcher at Stanford University, specializes in the field of muscle biology, the cytoskeleton.

His recent articles reflect a diverse array of research interests and contributions to the field:

Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration

Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

One must reconstitute the functions of interest from purified proteins

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

Structural changes in myosin affect chemo-mechanical properties of the myosin-actin interaction

Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments

Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes

James Spudich Information

University

Position

Professor of Biochemistry

Citations(all)

49332

Citations(since 2020)

7089

Cited By

47059

hIndex(all)

109

hIndex(since 2020)

45

i10Index(all)

280

i10Index(since 2020)

115

Email

University Profile Page

Google Scholar

James Spudich Skills & Research Interests

muscle biology

the cytoskeleton

Top articles of James Spudich

Title

Journal

Author(s)

Publication Date

Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration

Proceedings of the National Academy of Sciences

Soah Lee

Alison S Vander Roest

Cheavar A Blair

Kerry Kao

Samantha B Bremner

...

2024/5/7

Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

Proceedings of the National Academy of Sciences

Chao Liu

Anastasia Karabina

Artur Meller

Ayan Bhattacharjee

Colby J Agostino

...

2024/2/27

One must reconstitute the functions of interest from purified proteins

James A Spudich

2024

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

bioRxiv

Laura Sen Martin

Angel Fernandez Trasancos

Miguel A Lopez Unzu

Divya Pathak

Alessia Ferrarini

...

2024

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

bioRxiv

Neha Nandwani

Debanjan Bhowmik

Matthew C Childers

Rama Reddy Goluguri

Aminah Dawood

...

2024

Structural changes in myosin affect chemo-mechanical properties of the myosin-actin interaction

Biophysical Journal

Divya Pathak

Neha Nandwani

James A Spudich

Kathleen Ruppel

2023/2/10

Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments

Chao Liu

Kathleen M Ruppel

James A Spudich

2023/12/2

Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes

Biophysical Journal

Daniel Bernstein

Alison S Vander Roest

Sean Wu

Beth Pruitt

Mingming Zhao

...

2023/2/10

Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context

bioRxiv

Rahel A Woldeyes

Masataka Nishiga

Alison S Vander Roest

Leeya Engel

Prerna Giri

...

2023/10/26

Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy

Biophysical Journal

Alison S Vander Roest

James A Spudich

Kathleen Ruppel

Michael Regnier

Daniel Bernstein

2023/2/10

Abstract EC. 03: Distinct Molecular Signatures Of HCM-And DCM-causing Mutations At The Same Residue In The Transducer Of Cardiac Myosin

Circulation Research

Masataka Kawana

Rama Reddy Goluguri

Aminah Dawood

James A Spudich

Kathleen Ruppel

2023/8/4

Molecular characterization of a novel MYH7 mutation Q222H in a patient with severe dilated cardiomyopathy

Biophysical Journal

Masataka Kawana

Rama Reddy Goluguri

Aminah Dawood

James A Spudich

Kathleen Ruppel

2023/2/10

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients

Suman Nag

Sampath K Gollapudi

Carlos L Del Rio

James A Spudich

Robert McDowell

2023/7/28

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Biophysical Journal

Alessandro Grinzato

Daniel Auguin

Carlos Kikuti

Neha Nandwani

Dihia Moussaoui

...

2023/2/10

Homologous mutations in [... formula...], embryonic, and perinatal muscle myosins have divergent effects on molecular power generation

bioRxiv

Chao Liu

Anastasia Karabina

Artur Meller

Ayan Bhattacharjee

Colby J Agostino

...

2023/7/2

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

bioRxiv

Soah Lee

Alison S Vander Roest

Cheavar Blair

Kerry Kao

Samantha B Bremner

...

2023

Understanding the molecular basis of HCM-causing mutations in cardiac myosin and cardiac myosin binding protein-C

Biophysical Journal

Divya Pathak

Neha Nandwani

Kathleen Ruppel

James A Spudich

2022/2/11

Hypertrophic cardiomyopathy: mutations to mechanisms to therapies

Masataka Kawana

James A Spudich

Kathleen M Ruppel

2022/9/26

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

bioRxiv

Darshan V Trivedi

Anastasia Karabina

Gustave Bergnes

Alice Racca

Heba Wander

...

2022/9/10

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

Elife

Makenna M Morck

Debanjan Bhowmik

Divya Pathak

Aminah Dawood

James Spudich

...

2022/6/29

See List of Professors in James Spudich University(Stanford University)