James Spudich
Stanford University
H-index: 109
North America-United States
Top articles of James Spudich
Title | Journal | Author(s) | Publication Date |
---|---|---|---|
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration | Proceedings of the National Academy of Sciences | Soah Lee Alison S Vander Roest Cheavar A Blair Kerry Kao Samantha B Bremner | 2024/5/7 |
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation | Proceedings of the National Academy of Sciences | Chao Liu Anastasia Karabina Artur Meller Ayan Bhattacharjee Colby J Agostino | 2024/2/27 |
One must reconstitute the functions of interest from purified proteins | James A Spudich | 2024 | |
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy | bioRxiv | Laura Sen Martin Angel Fernandez Trasancos Miguel A Lopez Unzu Divya Pathak Alessia Ferrarini | 2024 |
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically | bioRxiv | Neha Nandwani Debanjan Bhowmik Matthew C Childers Rama Reddy Goluguri Aminah Dawood | 2024 |
Structural changes in myosin affect chemo-mechanical properties of the myosin-actin interaction | Biophysical Journal | Divya Pathak Neha Nandwani James A Spudich Kathleen Ruppel | 2023/2/10 |
Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments | Chao Liu Kathleen M Ruppel James A Spudich | 2023/12/2 | |
Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes | Biophysical Journal | Daniel Bernstein Alison S Vander Roest Sean Wu Beth Pruitt Mingming Zhao | 2023/2/10 |
Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context | bioRxiv | Rahel A Woldeyes Masataka Nishiga Alison S Vander Roest Leeya Engel Prerna Giri | 2023/10/26 |
Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy | Biophysical Journal | Alison S Vander Roest James A Spudich Kathleen Ruppel Michael Regnier Daniel Bernstein | 2023/2/10 |
Abstract EC. 03: Distinct Molecular Signatures Of HCM-And DCM-causing Mutations At The Same Residue In The Transducer Of Cardiac Myosin | Circulation Research | Masataka Kawana Rama Reddy Goluguri Aminah Dawood James A Spudich Kathleen Ruppel | 2023/8/4 |
Molecular characterization of a novel MYH7 mutation Q222H in a patient with severe dilated cardiomyopathy | Biophysical Journal | Masataka Kawana Rama Reddy Goluguri Aminah Dawood James A Spudich Kathleen Ruppel | 2023/2/10 |
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients | Suman Nag Sampath K Gollapudi Carlos L Del Rio James A Spudich Robert McDowell | 2023/7/28 | |
Cryo-EM structure of the folded-back state of human β-cardiac myosin | Biophysical Journal | Alessandro Grinzato Daniel Auguin Carlos Kikuti Neha Nandwani Dihia Moussaoui | 2023/2/10 |
Homologous mutations in [... formula...], embryonic, and perinatal muscle myosins have divergent effects on molecular power generation | bioRxiv | Chao Liu Anastasia Karabina Artur Meller Ayan Bhattacharjee Colby J Agostino | 2023/7/2 |
Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration | bioRxiv | Soah Lee Alison S Vander Roest Cheavar Blair Kerry Kao Samantha B Bremner | 2023 |
Understanding the molecular basis of HCM-causing mutations in cardiac myosin and cardiac myosin binding protein-C | Biophysical Journal | Divya Pathak Neha Nandwani Kathleen Ruppel James A Spudich | 2022/2/11 |
Hypertrophic cardiomyopathy: mutations to mechanisms to therapies | Masataka Kawana James A Spudich Kathleen M Ruppel | 2022/9/26 | |
A small-molecule myosin inhibitor as a targeted multi-stage antimalarial | bioRxiv | Darshan V Trivedi Anastasia Karabina Gustave Bergnes Alice Racca Heba Wander | 2022/9/10 |
Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function | Elife | Makenna M Morck Debanjan Bhowmik Divya Pathak Aminah Dawood James Spudich | 2022/6/29 |