J. Silvio Gutkind, Ph.D.
University of California, San Diego
H-index: 143
North America-United States
Top articles of J. Silvio Gutkind, Ph.D.
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
A novel combination therapy targeting RAF, MEK and FAK to overcome skin cutaneous melanoma treatment resistance | Cancer Research | Simone Lubrano Farhoud Faraji Rodolfo Daniel Cervantes-Villagrana Sydney Ramirez Nadia Arang | 2024/3/22 |
YAP-driven epigenetic reprogramming in head and neck cancer | Cancer Research | Adam Officer Farhoud Faraji Sydney Ramirez Alon Goren Pablo Tamayo | 2024/3/22 |
Genome-wide CRISPR screening reveals a central role for ferroptotic cell death in the anti-tumor response to mTOR inhibitors in HNSCC | Cancer Research | Keiichi Koshizuka Xingyu Wu Kuniaki Sato Pham Thuy Vo Gosia M Murawska | 2024/3/22 |
Many paths lead to immunology | Cell | Ana J García-Sáez Ana I Domingos J Silvio Gutkind Seema Mattoo Peng Du | 2024/4/25 |
An ex-vivo organotypic culture platform of mucinous carcinomatosis peritonei identifies CDK4-6 inhibition as a novel treatment | Cancer Research | Jonathan Weitz Daisuke Nishizaki Jay Patel Isabella Ng Siming Sun | 2024/3/22 |
Abstract CT260: A phase II trial of defactinib combined with avutometinib in patients with metastatic uveal melanoma | Cancer Research | Rino S Seedor Mizue Terai Amry Majeed Ryota Tanaka Andrew E Aplin | 2024/4/5 |
Structural dynamics in RhoGEF signaling investigated using model cell membranes | Biophysical Journal | Sandeep Ravala Sendi Adame-Garcia Sheng Li Chun-Liang Chen Michael A Cianfrocco | 2024/2/8 |
Abstract SY39-03: Illuminating the tumor immune GPCRome: Novel immunotherapy targets | Cancer Research | J Silvio Gutkind | 2024/4/5 |
Catalytic site mutations confer multiple states of G protein activation | Science signaling | Natalie Hewitt Ning Ma Nadia Arang Sarah A Martin Ajit Prakash | 2023/2/14 |
Direct reprogramming of oral epithelial progenitor cells to cancer stem cells at single cell resolution in vivo | bioRxiv | Farhoud Faraji Sydney I Ramirez Lauren Clubb Kuniaki Sato Paola Y Anguiano Quiroz | 2023 |
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response | Nature communications | Meghana Pagadala Timothy J Sears Victoria H Wu Eva Pérez-Guijarro Hyo Kim | 2023/5/12 |
A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal | Cancers | Jesse R Qualliotine Takuya Nakagawa Sara Brin Rosenthal Sayed Sadat Carmen Ballesteros-Merino | 2023/9/1 |
AXL activates YAP through the EGFR–LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma | Oncogene | Kento Okamoto Toshinori Ando Hiroki Izumi Susumu S Kobayashi Tomoaki Shintani | 2023/9/22 |
483 Extra-nodal memory T cell populations confer durable anticancer immunity following successful primary tumor responses to ICI | Shiqi Tang Riyam Al Msari J Silvio Gutkind Robert Saddawi-Konefka | 2023/11/1 | |
Gα12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion | Scientific Reports | Olga Meiri Chaim Shunichiro Miki Briana C Prager Jianhui Ma Anthony Y Jeong | 2023/12/16 |
Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry | Journal of Biological Chemistry | Nadia Arang Simone Lubrano Damiano Cosimo Rigiracciolo Daniela Nachmanson Scott M Lippman | 2023/2/1 |
Abstract CT047: A phase 2 study of ipatasertib in combination with pembrolizumab for first line treatment of recurrent or metastatic squamous cell cancer of the head and neck | Cancer Research | Jacob S Thomas Robert Hsu Victoria Villaflor Jonathan Riess Jorge Nieva | 2023/4/14 |
The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure | Nature immunology | Victoria H Wu Bryan S Yung Farhoud Faraji Robert Saddawi-Konefka Zhiyong Wang | 2023/8 |
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 | bioRxiv | Sandeep K Ravala Sendi Rafael Adame-Garcia Sheng Li Chun-Liang Chen Michael A Cianfrocco | 2023/9/16 |
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor | Journal of Biological Chemistry | Valeria Burghi Justine S Paradis Adam Officer Sendi Rafael Adame-Garcia Xingyu Wu | 2023/11/1 |
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