Harry T. Orr
University of Minnesota-Twin Cities
H-index: 100
North America-United States
Top articles of Harry T. Orr
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease. | JCI insight | Lisa Duvick W Michael Southern Kellie A Benzow Zoe N Burch Hillary P Handler | 2024/3/21 |
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1 | Neuron | Leon Tejwani Neal G Ravindra Changwoo Lee Yubao Cheng Billy Nguyen | 2024/2/7 |
Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway | Harry T Orr | 2023/8 | |
Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla | Frontiers in Neuroscience | Ivan Tkáč Tiankai Xie Nitya Shah Sarah Larson Janet M Dubinsky | 2023/10/25 |
Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias | bioRxiv | Luke C Bartelt Pawel M Switonski Grażyna Adamek Juliana Carvalho Lisa A Duvick | 2023/5/11 |
Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1 | bioRxiv | Logan M Morrison Haoran Huang Hillary P Handler Min Fu David D Bushart | 2023/10/23 |
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1 | Neuron | Stephanie L Coffin Mark A Durham Larissa Nitschke Eder Xhako Amanda M Brown | 2023/2/15 |
HD and SCA1: Tales from two 30-year journeys since gene discovery | Leslie M Thompson Harry T Orr | 2023/10/12 | |
Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles | Neuron | Hillary P Handler Lisa Duvick Jason S Mitchell Marija Cvetanovic Molly Reighard | 2023/2/15 |
Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition | Molecular psychiatry | Dong Liu Carmen Nanclares Konstanze Simbriger Kun Fang Ethan Lorsung | 2023/9 |
Regional vulnerability in a neurodegenerative disease: Delineating SCA1 CNS and muscle therapeutic targets using a conditional mutant ATXN1 mouse. | Biorxiv: the Preprint Server for Biology | L Duvick WM Southern K Benzow HP Handler JS Mitchell | 2023/2/8 |
The PERK pathway: beneficial or detrimental for neurodegenerative diseases and tumor growth and cancer | Gourango Talukdar Harry T Orr Zhixin Lei | 2023/8/15 | |
60 Impact of Reducing the Nuclear Mutant ATXN1 on Spinocerebellar Ataxia-Like Phenotype | Journal of the International Neuropsychological Society | Kathleen B Mather Lisa A Duvick Hillary P Handler Harry T Orr | 2023/11 |
Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model | Plos one | William Miller Charles Lewis Humphrey Pruett William Stone Cindy Eide Megan Riddle | 2022/10/17 |
Consensus paper: strengths and weaknesses of animal models of spinocerebellar ataxias and their clinical implications | The Cerebellum | Jan Cendelin Marija Cvetanovic Mandi Gandelman Hirokazu Hirai Harry T Orr | 2022/6 |
Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1 | The Journal of clinical investigation | Won-Seok Lee Ismael Al-Ramahi Hyun-Hwan Jeong Youjin Jang Tao Lin | 2022/5/2 |
Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model | JCI insight | James P Orengo Larissa Nitschke Meike E van der Heijden Nicholas A Ciaburri Harry T Orr | 2022/4/4 |
Stephen T. Warren, Ph. D.(1953–2021): A remembrance | The American Journal of Human Genetics | David L Nelson Janelle Clark Kathryn Garber Thomas Glover Terry Hassold | 2022/1/6 |
Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1 | JCI insight | Larissa Nitschke Stephanie L Coffin Eder Xhako Dany B El-Najjar James P Orengo | 2021/2/2 |
Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice | Cell reports | Emily AL Wozniak Zhao Chen Sharan Paul Praseuth Yang Karla P Figueroa | 2021/10/12 |
