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George Chandy

About George Chandy

George Chandy, With an exceptional h-index of 77 and a recent h-index of 37 (since 2020), a distinguished researcher at Nanyang Technological University, specializes in the field of ion channels, immunology, pharmacology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma

High Extracellular K+ Drives T-Cell Exhaustion by Disrupting TCR Signals Implicated in Tumor Immune Evasion

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

Potent and selective inhibitors of the calcium-activated potassium channel, kca3. 1, for use as platform therapeutics

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics

Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1

Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1

Spatially-resolved transcriptomics define clinically relevant subsets of macrophages in diffuse large B-cell lymphoma

George Chandy Information

University

Position

Professor of Molecular Physiology Lee Kong Chian School of Medicine

Citations(all)

24178

Citations(since 2020)

4686

Cited By

21105

hIndex(all)

77

hIndex(since 2020)

37

i10Index(all)

161

i10Index(since 2020)

92

Email

University Profile Page

Google Scholar

George Chandy Skills & Research Interests

ion channels

immunology

pharmacology

Top articles of George Chandy

Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma

Nature Communications

2024/3/8

Min Liu
Min Liu

H-Index: 9

Nicholas Syn
Nicholas Syn

H-Index: 20

Jayalakshmi
Jayalakshmi

H-Index: 0

Sanjay De Mel
Sanjay De Mel

H-Index: 13

Xiaofei Ye
Xiaofei Ye

H-Index: 7

Qiang Pan-Hammarström
Qiang Pan-Hammarström

H-Index: 36

Claudio Tripodo
Claudio Tripodo

H-Index: 41

Anand D Jeyasekharan
Anand D Jeyasekharan

H-Index: 17

High Extracellular K+ Drives T-Cell Exhaustion by Disrupting TCR Signals Implicated in Tumor Immune Evasion

2024/3/19

Shuwen Chen
Shuwen Chen

H-Index: 12

Richard Webster
Richard Webster

H-Index: 10

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads

2023/12/31

Karoline Sanches
Karoline Sanches

H-Index: 3

Potent and selective inhibitors of the calcium-activated potassium channel, kca3. 1, for use as platform therapeutics

2023/12/28

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics

Journal of Chemical Information and Modeling

2023/5/5

Karoline Sanches
Karoline Sanches

H-Index: 3

Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE

2023/4/26

Heike Wulff
Heike Wulff

H-Index: 44

Voltage-gated potassium channels (Kv) in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE

2023/4/26

David Mckinnon
David Mckinnon

H-Index: 17

Bernardo Rudy
Bernardo Rudy

H-Index: 40

Xiaoliang Wang
Xiaoliang Wang

H-Index: 8

Spatially-resolved transcriptomics define clinically relevant subsets of macrophages in diffuse large B-cell lymphoma

medRxiv

2023/3/6

Min Liu
Min Liu

H-Index: 9

Sanjay De Mel
Sanjay De Mel

H-Index: 13

Esther Chan
Esther Chan

H-Index: 6

Claudio Tripodo
Claudio Tripodo

H-Index: 41

Anand D Jeyasekharan
Anand D Jeyasekharan

H-Index: 17

Augmenting the activity of calcium-activated potassium channel KCa3. 1 revitalizes T-cell function in the immunosuppressive tumor microenvironment

Biophysical Journal

2023/2/10

Shuwen Chen
Shuwen Chen

H-Index: 12

Heike Wulff
Heike Wulff

H-Index: 44

Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint

2022/9/1

Ritu Verma
Ritu Verma

H-Index: 6

Mechanisms underlying C-type inactivation in Kv channels: Lessons from structures of human Kv1. 3 and fly shaker-IR channels

2022/6/27

Imaging Kv1. 3 expressing memory T cells as a marker of immunotherapy response

Cancers

2022/2/26

A new kCa3. 1 channel activator SKA-346 boosts T-cell antitumor response in the immune suppressive microenvironment

Biophysical Journal

2022/2/11

Shuwen Chen
Shuwen Chen

H-Index: 12

Heike Wulff
Heike Wulff

H-Index: 44

Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

Nature Microbiology

2022/2

Jeremie Poschmann
Jeremie Poschmann

H-Index: 11

Catherine Riou
Catherine Riou

H-Index: 18

Dilip Kumar
Dilip Kumar

H-Index: 4

Andrea Lee
Andrea Lee

H-Index: 2

Zhong Zhuang
Zhong Zhuang

H-Index: 2

Gennaro De Libero
Gennaro De Libero

H-Index: 31

Rearrangement of a unique Kv1. 3 selectivity filter conformation upon binding of a drug

Proceedings of the National Academy of Sciences

2022/2/1

Yue Zhao
Yue Zhao

H-Index: 3

Igor Vorobyov
Igor Vorobyov

H-Index: 22

Author Correction: Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection

Nature Microbiology

2022

Jeremie Poschmann
Jeremie Poschmann

H-Index: 11

Catherine Riou
Catherine Riou

H-Index: 18

Dilip Kumar
Dilip Kumar

H-Index: 4

Andrea Lee
Andrea Lee

H-Index: 2

Zhong Zhuang
Zhong Zhuang

H-Index: 2

Gennaro De Libero
Gennaro De Libero

H-Index: 31

Kv1. 3 channel up-regulation in peripheral blood T lymphocytes of patients with multiple sclerosis

Frontiers in Pharmacology

2021/9/23

Christine Beeton
Christine Beeton

H-Index: 29

Cornelia Poulopoulou
Cornelia Poulopoulou

H-Index: 7

Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3

Cell discovery

2021/6/1

Yue Zhao
Yue Zhao

H-Index: 3

Hao Dong
Hao Dong

H-Index: 2

Liang Xiao
Liang Xiao

H-Index: 15

Yong Zhang
Yong Zhang

H-Index: 7

Yuqin Yang
Yuqin Yang

H-Index: 3

CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice

Frontiers in immunology

2020/9/11

Min Liu
Min Liu

H-Index: 9

Yong Fan
Yong Fan

H-Index: 11

Lei Sun
Lei Sun

H-Index: 4

Qingfeng Chen
Qingfeng Chen

H-Index: 10

Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin

ACS pharmacology & translational science

2020/5/14

Bankala Krishnarjuna
Bankala Krishnarjuna

H-Index: 9

Dahai Luo
Dahai Luo

H-Index: 27

Dharmeshkumar Patel
Dharmeshkumar Patel

H-Index: 4

Zhong Zhuang
Zhong Zhuang

H-Index: 2

Julien Lescar
Julien Lescar

H-Index: 42

Heike Wulff
Heike Wulff

H-Index: 44

Christine Beeton
Christine Beeton

H-Index: 29

See List of Professors in George Chandy University(Nanyang Technological University)