Fred Guengerich

Fred Guengerich

Vanderbilt University

H-index: 175

North America-United States

About Fred Guengerich

Fred Guengerich, With an exceptional h-index of 175 and a recent h-index of 51 (since 2020), a distinguished researcher at Vanderbilt University, specializes in the field of Enzymology, drug metabolism, cytochrome P450, mutagenesis.

His recent articles reflect a diverse array of research interests and contributions to the field:

Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells

Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes

Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17, 20-lyase

Oxygen‐18 Labeling Reveals a Mixed Fe− O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation

Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4

Principles of Xenobiotic Metabolism (Biotransformation)

Fred Guengerich Information

University

Vanderbilt University

Position

Professor of Biochemistry

Citations(all)

125244

Citations(since 2020)

18000

Cited By

111437

hIndex(all)

175

hIndex(since 2020)

51

i10Index(all)

958

i10Index(since 2020)

408

Email

University Profile Page

Vanderbilt University

Fred Guengerich Skills & Research Interests

Enzymology

drug metabolism

cytochrome P450

mutagenesis

Top articles of Fred Guengerich

Title

Journal

Author(s)

Publication Date

Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

Journal of Medicinal Chemistry

Muthuraj Prakash

Yukihiro Itoh

Yoshie Fujiwara

Yukari Takahashi

Yuri Takada

...

2021/11/3

In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells

Chemical Research in Toxicology

Shotaro Uehara

Norie Murayama

Yuichiro Higuchi

Makiko Shimizu

Hiroshi Suemizu

...

2024/4/16

Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes

Slobodan P Rendic

F Peter Guengerich

2024/3/23

Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17, 20-lyase

Journal of Biological Chemistry

Yasuhiro Tateishi

Stephany N Webb

Bian Li

Lu Liu

Kristie Lindsey Rose

...

2024/3/1

Oxygen‐18 Labeling Reveals a Mixed Fe− O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation

Angewandte Chemie

Kevin D McCarty

Yasuhiro Tateishi

Tatiana Y Hargrove

Galina I Lepesheva

F Peter Guengerich

2024/2/26

Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

Journal of Biological Chemistry

F Peter Guengerich

2024/2/1

Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4

ACS catalysis

Yasuhiro Tateishi

Kevin D McCarty

Martha V Martin

F Peter Guengerich

2024/1/31

Principles of Xenobiotic Metabolism (Biotransformation)

Mirza Bojić

Željko Debeljak

F Peter Guengerich

2024/1/5

The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive

Journal of Biological Chemistry

Kevin D McCarty

Lu Liu

Yasuhiro Tateishi

Hannah L Wapshott-Stehli

F Peter Guengerich

2023/11/24

Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1

Journal of Biological Chemistry

Kevin D McCarty

Molly E Sullivan

Yasuhiro Tateishi

Tatiana Y Hargrove

Galina I Lepesheva

...

2023/7/1

Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

Nucleic Acids Research

Jeffrey Y Jian

Kevin D McCarty

Jo Ann W Byl

F Peter Guengerich

Keir C Neuman

...

2023/5/8

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro

Xenobiotica

Michiaki Kojima

Kanami Machida

Sumie Cho

Daichi Watanabe

Hiroyuki Seki

...

2023/5/4

FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients

Food and Chemical Toxicology

Thomas J Rosol

Samuel M Cohen

Gerhard Eisenbrand

Shoji Fukushima

Nigel J Gooderham

...

2023/5/1

FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes

Food and Chemical Toxicology

Jeanne M Davidsen

Samuel M Cohen

Gerhard Eisenbrand

Shoji Fukushima

Nigel J Gooderham

...

2023/5/1

Identification of Three Human POLH Germline Variants Defective in Complementing the UV-and Cisplatin-Sensitivity of POLH-Deficient Cells

International Journal of Molecular Sciences

Mina Yeom

Jin-Kyung Hong

Joo-Ho Shin

Yunjong Lee

Frederick Peter Guengerich

...

2023/3/8

Hydroxylation and lyase reactions of steroids catalyzed by mouse cytochrome P450 17A1 (Cyp17a1)

Journal of inorganic biochemistry

Sung-Gyu Lee

Vitchan Kim

Gyu-Hyeong Lee

Changmin Kim

Eunseo Jeong

...

2023/3/1

The Importance of Biotransformation

F Peter Guengerich

2023/1/1

Cytochrome P450 enzymes as drug targets in human disease

Drug Metabolism and Disposition

F Peter Guengerich

2023/1/1

Steroid 17α-hydroxylase/17, 20-lyase (cytochrome P450 17A1)

F Peter Guengerich

Kevin D McCarty

Yasuhiro Tateishi

Lu Liu

2023/1/1

Direct addition of flavors, including taste and flavor modifiers

Ivonne MCM Rietjens

Samuel M Cohen

Gerhard Eisenbrand

Shoji Fukushima

Nigel J Gooderham

...

2023/1/1

See List of Professors in Fred Guengerich University(Vanderbilt University)

Fred Guengerich FAQs

What is Fred Guengerich's h-index at Vanderbilt University?

The h-index of Fred Guengerich has been 51 since 2020 and 175 in total.

What are Fred Guengerich's top articles?

The articles with the titles of

Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells

Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes

Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17, 20-lyase

Oxygen‐18 Labeling Reveals a Mixed Fe− O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation

Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4

Principles of Xenobiotic Metabolism (Biotransformation)

...

are the top articles of Fred Guengerich at Vanderbilt University.

What are Fred Guengerich's research interests?

The research interests of Fred Guengerich are: Enzymology, drug metabolism, cytochrome P450, mutagenesis

What is Fred Guengerich's total number of citations?

Fred Guengerich has 125,244 citations in total.

What are the co-authors of Fred Guengerich?

The co-authors of Fred Guengerich are Thomas M. Harris, Chul-Ho Yun.

Co-Authors

H-index: 72
Thomas M. Harris

Thomas M. Harris

Vanderbilt University

H-index: 46
Chul-Ho Yun

Chul-Ho Yun

Chonnam National University

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