Fabrizio Chiti

About Fabrizio Chiti

Fabrizio Chiti, With an exceptional h-index of 68 and a recent h-index of 39 (since 2020), a distinguished researcher at Università degli Studi di Firenze, specializes in the field of protein aggregation, protein misfolding, Alzheimer disease, Parkinson disease, amyotroèphic lateral sclerosis.

His recent articles reflect a diverse array of research interests and contributions to the field:

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Leveraging Machine Learning-Guided Molecular Simulations Coupled with Experimental Data to Decipher Membrane Binding Mechanisms of Aminosterols

An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature

Single domain antibodies as promising tools for the selective detection and neutralization of neurotoxic Aβ42 oligomers in the cerebrospinal fluid of Alzheimer’s …

Amyloid Aggregation Is Potently Slowed Down by Osmolytes Due to Compaction of Partially Folded State

Fabrizio Chiti Information

University

Position

Professor of Biochemistry

Citations(all)

31136

Citations(since 2020)

9631

Cited By

25758

hIndex(all)

68

hIndex(since 2020)

39

i10Index(all)

159

i10Index(since 2020)

107

Email

University Profile Page

Google Scholar

Fabrizio Chiti Skills & Research Interests

protein aggregation

protein misfolding

Alzheimer disease

Parkinson disease

amyotroèphic lateral sclerosis

Top articles of Fabrizio Chiti

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

2024/12

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Michele Vendruscolo
Michele Vendruscolo

H-Index: 70

Structure–Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates

Journal of the American Chemical Society

2024/4/3

Putative novel CSF biomarkers of Alzheimer’s disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort

Translational Neurodegeneration

2024/3/8

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Alzheimer's Research & Therapy

2024/1/18

Leveraging Machine Learning-Guided Molecular Simulations Coupled with Experimental Data to Decipher Membrane Binding Mechanisms of Aminosterols

bioRxiv

2024

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature

Annals of Medicine

2023/12/31

Single domain antibodies as promising tools for the selective detection and neutralization of neurotoxic Aβ42 oligomers in the cerebrospinal fluid of Alzheimer’s …

Alzheimer's & Dementia

2023/12

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Cristina Cecchi
Cristina Cecchi

H-Index: 24

Amyloid Aggregation Is Potently Slowed Down by Osmolytes Due to Compaction of Partially Folded State

Journal of Molecular Biology

2023/11/15

Daniel Harries
Daniel Harries

H-Index: 26

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Alzheimer Disease Detection from Raman Spectroscopy of the Cerebrospinal Fluid via Topological Machine Learning

Engineering Proceedings

2023/10/27

Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

Journal of Medicinal Chemistry

2023/7/11

Single domain antibodies as new detectors of neurotoxic Aβ42 oligomers

Alzheimer's & Dementia

2023/6

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Cristina Cecchi
Cristina Cecchi

H-Index: 24

Characterization of pairs of toxic and nontoxic misfolded protein oligomers elucidates the structural determinants of oligomer toxicity in protein misfolding diseases

2023/4/18

Michele Vendruscolo
Michele Vendruscolo

H-Index: 70

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol

Colloids and Surfaces B: Biointerfaces

2023/2/1

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Gabriella Caminati
Gabriella Caminati

H-Index: 13

EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity

Chemico-Biological Interactions

2023/2/1

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Michele Vendruscolo
Michele Vendruscolo

H-Index: 70

Sphingosine 1‐phosphate attenuates neuronal dysfunction induced by amyloid‐β oligomers through endocytic internalization of NMDA receptors

The FEBS Journal

2023/1

Biophysical characterization of full‐length TAR DNA‐binding protein (TDP‐43) phase separation

Protein Science

2022/12

Cristina Cecchi
Cristina Cecchi

H-Index: 24

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases

2022/11

Fabrizio Chiti
Fabrizio Chiti

H-Index: 38

Cristina Cecchi
Cristina Cecchi

H-Index: 24

The role of structural dynamics in the thermal adaptation of hyperthermophilic enzymes

Frontiers in Molecular Biosciences

2022/9/7

Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species

Cellular and Molecular Life Sciences

2022/9

See List of Professors in Fabrizio Chiti University(Università degli Studi di Firenze)