Eric Chun Yong Chan

Eric Chun Yong Chan

National University of Singapore

H-index: 44

Asia-Singapore

About Eric Chun Yong Chan

Eric Chun Yong Chan, With an exceptional h-index of 44 and a recent h-index of 26 (since 2020), a distinguished researcher at National University of Singapore, specializes in the field of xenobiotic, reactive metabolite, CYP450 enzymes, metabolic pathway regulation, drug-drug interaction.

His recent articles reflect a diverse array of research interests and contributions to the field:

Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes

Quantification of the irreversible fibroblast growth factor receptor inhibitor futibatinib by UPLC-MS/MS: Application to the metabolic stability assay in human liver microsomes …

Physiologically‐Based Pharmacokinetic Modelling to Investigate Baricitinib and Tofacitinib Dosing Recommendations for COVID‐19 in Geriatrics

In vitro approaches for the identification and characterization of urinary metabolite biomarkers of synthetic cannabinoid ADB-BUTINACA

Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore

Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug‐drug interactions with rivaroxaban

Identification of infigratinib as a potent reversible inhibitor and mechanism-based inactivator of CYP2J2: nascent evidence for a potential in vivo metabolic drug-drug …

Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A

Eric Chun Yong Chan Information

University

Position

Professor (Department of Pharmacy Faculty of Science)

Citations(all)

5674

Citations(since 2020)

2352

Cited By

4108

hIndex(all)

44

hIndex(since 2020)

26

i10Index(all)

89

i10Index(since 2020)

70

Email

University Profile Page

National University of Singapore

Google Scholar

View Google Scholar Profile

Eric Chun Yong Chan Skills & Research Interests

xenobiotic

reactive metabolite

CYP450 enzymes

metabolic pathway regulation

drug-drug interaction

Top articles of Eric Chun Yong Chan

Title

Journal

Author(s)

Publication Date

Evaluation of stool short chain fatty acids profiles in the first year of life with childhood atopy-related outcomes

Frontiers in allergy

Hsin Yue Cheng

James Chun Yip Chan

Gaik Chin Yap

Chiung-Hui Huang

Dorinda Yan Qin Kioh

...

2022

Quantification of the irreversible fibroblast growth factor receptor inhibitor futibatinib by UPLC-MS/MS: Application to the metabolic stability assay in human liver microsomes …

Journal of Pharmaceutical and Biomedical Analysis

Lloyd Wei Tat Tang

Eric Chun Yong Chan

2022/5/30

Physiologically‐Based Pharmacokinetic Modelling to Investigate Baricitinib and Tofacitinib Dosing Recommendations for COVID‐19 in Geriatrics

Clinical Pharmacology & Therapeutics

Ziteng Wang

Eric Chun Yong Chan

2022/4/5

In vitro approaches for the identification and characterization of urinary metabolite biomarkers of synthetic cannabinoid ADB-BUTINACA

Toxicologie Analytique et Clinique

Evelyn Mei Ling Goh

Chi Hon Sia

Ziteng Wang

Ching Yee Fong

Hooi Yan Moy

...

2022/9/1

Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore

Cardiovascular Drugs and Therapy

Xin Qin Soh

Doreen Su-Yin Tan

Eric Chun Yong Chan

2022/5/14

Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug‐drug interactions with rivaroxaban

Biopharmaceutics & Drug Disposition

Lloyd Wei Tat Tang

Tino Woon Huai Cheong

Eric Chun Yong Chan

2022/4

Identification of infigratinib as a potent reversible inhibitor and mechanism-based inactivator of CYP2J2: nascent evidence for a potential in vivo metabolic drug-drug …

Journal of Pharmacology and Experimental Therapeutics

Lloyd Wei Tat Tang

Guoyi Wu

Eric Chun Yong Chan

2022/8/1

Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A

Drug Metabolism and Disposition

Lloyd Wei Tat Tang

Wan Wei

Ravi Kumar Verma

Siew Kwan Koh

Lei Zhou

...

2022/5/1

Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells

Toxicology Research

Lloyd Wei Tat Tang

Royden Yu Ren Lim

Gopalakrishnan Venkatesan

Eric Chun Yong Chan

2022/4

Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A

Drug Metabolism and Disposition

Lloyd Wei Tat Tang

Jiaxin Fu

Siew Kwan Koh

Guoyi Wu

Lei Zhou

...

2022/7/1

Physiologically‐Based Pharmacokinetic Modeling‐Guided Dose Management of Oral Anticoagulants when Initiating Nirmatrelvir/Ritonavir (Paxlovid) for COVID‐19 Treatment

Clinical Pharmacology & Therapeutics

Ziteng Wang

Eric Chun Yong Chan

2022/10

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

Acta Pharmaceutica Sinica B

Aneesh V Karkhanis

Gopalakrishnan Venkatesan

Ryuichi Kambayashi

Jacqueline Wen Hui Leow

Marcus Qingrui Han

...

2022/3/16

Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology.

Advances in Pharmacology (San Diego, Calif.)

Jacqueline Wen Hui Leow

Lloyd Wei Tat Tang

Eric Chun Yong Chan

2022/6/30

Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model

Cellular and Molecular Life Sciences

Lei Deng

Lukasz Wojciech

Chin Wen Png

Eileen Yiling Koh

Thet Tun Aung

...

2022/5

Inhibition of cytochrome P450 2J2-mediated metabolism of rivaroxaban and arachidonic acid by ibrutinib and osimertinib

Drug Metabolism and Disposition

Ziteng Wang

Eric Chun Yong Chan

2022/10/1

Inhibition of cytochrome P450 enzymes and uridine 5′-diphospho-glucuronosyltransferases by vicagrel in human liver microsomes: A prediction of potential drug-drug interactions

Chemico-biological interactions

Shuaibing Liu

Ziteng Wang

Eric Chan

Yibo Zhao

Jian Kang

...

2022/1/25

Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

Food Bioscience

Yuxiang Gu

Xing Li

Haoran Chen

Yue Sun

Lin Yang

...

2022/6/1

Application of a physiologically based pharmacokinetic model of rivaroxaban to prospective simulations of drug–drug–disease interactions with protein kinase inhibitors in …

Annual for Hospital Pharmacy

Maya Radeva-Ilieva

Kaloyan Georgiev

2020/10/1

Identification of urinary biomarkers of synthetic cannabinoids BZO-HEXOXIZID, BZO-POXIZID, 5F-BZO-POXIZID and BZO-CHMOXIZID from authentic urine samples in Singapore

Toxicologie Analytique et Clinique

Hian Twan Chang

Ching Yee Fong

Keane Zhi Hao Lee

Ziteng Wang

Eric Chun Yong Chan

...

2022/9/1

Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4

Drug Metabolism and Disposition

Lloyd Wei Tat Tang

Jian Wei Teng

Ravi Kumar Verma

Siew Kwan Koh

Lei Zhou

...

2021/9/1

See List of Professors in Eric Chun Yong Chan University(National University of Singapore)

Co-Authors

H-index: 166
Jeremy K Nicholson

Jeremy K Nicholson

Murdoch University

H-index: 58
Paul C. HO

Paul C. HO

National University of Singapore

H-index: 40
Han Kiat Ho

Han Kiat Ho

National University of Singapore

H-index: 31
Lam Siew Hong

Lam Siew Hong

National University of Singapore

H-index: 6
Hui Ting Chng

Hui Ting Chng

National University of Singapore

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