Edward P. O'Brien
Penn State University
H-index: 32
North America-United States
Top articles of Edward P. O'Brien
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Binding small-molecule drugs may avoid protein misfolding into non-covalent lasso entanglements | Biophysical Journal | Yang Jiang Edward P O'Brien | 2024/2/8 |
Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance | Journal of Molecular Biology | Viraj Rana Ian Sitarik Justin Petucci Yang Jiang Hyebin Song | 2024/3/15 |
A newly predicted class of protein misfolding explains decades-old biochemical and molecular biology data | Biophysical Journal | Edward P O’Brien | 2024/2/8 |
Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2 | The Journal of Chemical Physics | Pham Dang Lan Daniel A Nissley Edward P O’Brien Toan T Nguyen Mai Suan Li | 2024/2/7 |
It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs | PLoS computational biology | Yang Jiang Charlotte M Deane Garrett M Morris Edward P O’Brien | 2024/3/12 |
Synonymous mutations can alter protein dimerization through localized interface misfolding involving self-entanglements | Journal of Molecular Biology | Pham Dang Lan Daniel Allen Nissley Ian Sitarik Quyen V Vu Yang Jiang | 2024/2/9 |
Native entanglement misfolding can cause a loss-of-function in essential proteins | Biophysical Journal | Ian M Sitarik Edward P O'Brien | 2024/2/8 |
Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study | The Journal of Physical Chemistry B | Quyen V Vu Daniel A Nissley Yang Jiang Edward P O’Brien Mai Suan Li | 2023/5/18 |
How synonymous mutations alter enzyme structure and function over long timescales | Nature Chemistry | Yang Jiang Syam Sundar Neti Ian Sitarik Priya Pradhan Philip To | 2023/3 |
Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer | BMC bioinformatics | Yiyun Rao Nabeel Ahmed Justin Pritchard Edward P O’Brien | 2023/12/7 |
How soluble misfolded proteins bypass chaperones at the molecular level | Nature communications | Ritaban Halder Daniel A Nissley Ian Sitarik Yang Jiang Yiyun Rao | 2023/6/21 |
Correction to “Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force” | Biochemistry | Sarah E Leininger Judith Rodriguez Quyen V Vu Yang Jiang Mai Suan Li | 2022/1/5 |
Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional | Nature communications | Daniel A Nissley Yang Jiang Fabio Trovato Ian Sitarik Karthik B Narayan | 2022/6/2 |
Cocktail of REGN antibodies binds more strongly to SARS-CoV-2 than its components, but the Omicron variant reduces its neutralizing ability | The Journal of Physical Chemistry B | Hung Nguyen Pham Dang Lan Daniel A Nissley Edward P O’Brien Mai Suan Li | 2022/4/11 |
Machine-learning guided biophysical model development: application to ribosome catalysis | Biophysical Journal | Yang Jiang Justin Petucci Nishant Soni Vasant Honavar Edward O'Brien | 2022/2/11 |
Modeling Ensembles of Enzyme Reaction Pathways with Hi-MSM Reveals the Importance of Accounting for Pathway Diversity | The Journal of Physical Chemistry B | Joseph R Persichetti Yang Jiang Phillip S Hudson Edward P O’Brien | 2022/11/16 |
A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments | Nature communications | Boyang Zhao Yiyun Rao Scott Leighow Edward P O’Brien Luke Gilbert | 2022/2/2 |
A Newly Identified Class of Protein Misfolding in All-atom Folding Simulations Consistent with Limited Proteolysis Mass Spectrometry | bioRxiv | Quyen V Vu Ian Sitarik Yang Jiang Divya Yadav Piyoosh Sharma | 2022/7/20 |
MutSigCVsyn: Identification of Thirty Synonymous Cancer Drivers | bioRxiv | Yiyun Rao Nabeel Ahmed Justin Pritchard Edward O’Brien | 2022/1/18 |
Pulse labeling reveals the tail end of protein folding by proteome profiling | Cell reports | Mang Zhu Erich R Kuechler Ryan WK Wong Gaetano Calabrese Ian M Sitarik | 2022/7/19 |
Co-Authors
