Douglas M Fowler
University of Washington
H-index: 41
North America-United States
Top articles of Douglas M Fowler
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Multiplex, multimodal mapping of variant effects in secreted proteins | bioRxiv | Nicholas A Popp Rachel L Powell Melinda K Wheelock Brendan D Zapp Kristen J Holmes | 2024 |
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes | Circulation: Genomic and Precision Medicine | Clayton E Friedman Shawn Fayer Sriram Pendyala Wei-Ming Chien Alexander Loiben | 2024/2/16 |
O01: Using multiplexed functional data to reduce the VUS burden in populations underrepresented in genomic medicine | Genetics in Medicine Open | Moez Dawood Shawn Fayer Mason Post Divya Kalra Karynne Patterson | 2024/1/1 |
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics | Cell Chemical Biology | Sujata Chakraborty Ethan Ahler Jessica J Simon Linglan Fang Zachary E Potter | 2024/2/15 |
CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods | Null Null Shantanu Jain Constantina Bakolitsa Steven E Brenner Predrag Radivojac | 2024 | |
Will variants of uncertain significance still exist in 2030? | Douglas M Fowler Heidi L Rehm | 2024/1/4 | |
A missense variant effect map for the human tumour suppressor protein CHK2 | bioRxiv | Marinella Gebbia Daniel I Zimmerman Rosanna Jiang Maria Nguyen Jochen Weile | 2024 |
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq | bioRxiv | Jessica J Simon Douglas Fowler Dustin J Maly | 2024 |
Pacybara: Accurate long-read sequencing for barcoded mutagenized allelic libraries | Bioinformatics | Jochen Weile Gabrielle Ferra Gabriel Boyle Sriram Pendyala Clara Amorosi | 2024/4/1 |
Defining and Reducing Variant Classification Disparities | medRxiv | Moez Dawood Shawn Fayer Sriram Pendyala Mason Post Divya Kalra | 2024 |
A mutational atlas for Parkin proteostasis | Nature Communications | Lene Clausen Vasileios Voutsinos Matteo Cagiada Kristoffer E Johansson Martin Grønbæk-Thygesen | 2024/2/20 |
Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases | Philip Hieter Brenda Andrews Douglas Fowler Hugo Bellen | 2023/8 | |
Optogenetic microwell Array screening system: A high-throughput engineering platform for genetically encoded fluorescent indicators | ACS sensors | Michael Rappleye Sarah J Wait Justin Daho Lee Jamison C Siebart Lily Torp | 2023/11/13 |
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology | bioRxiv | Ayesha Muhammad Maria E Calandranis Bian Li Tao Yang Daniel J Blackwell | 2023/4/29 |
A chemically controlled Cas9 switch enables temporal modulation of diverse effectors | Nature chemical biology | Cindy T Wei Nicholas A Popp Omri Peleg Rachel L Powell Elhanan Borenstein | 2023/8 |
Multiplexed Generation and Functional Annotation of Hypertrophic Cardiomyopathy-Associated MYH7 Missense Variants in Isogenic Gene-Edited Stem Cell … | Circulation | Clayton E Friedman Shawn Fayer Sriram Pendyala Wei-Ming Chien Alexander Loiben | 2023/11/7 |
Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff | bioRxiv | Gabriel E Boyle Katherine Sitko Jared G Galloway Hugh K Haddox Aisha Haley Bianchi | 2023 |
An Atlas of Variant Effects to understand the genome at nucleotide resolution | Genome Biology | Douglas M Fowler David J Adams Anna L Gloyn William C Hahn Debora S Marks | 2023/7/3 |
Deep mutational scanning reveals a tight correlation between protein degradation and toxicity of thousands of non-native aspartoacylase protein variants | bioRxiv | Martin Grønbæk-Thygesen Vasileios Voutsinos Kristoffer E Johansson Thea K Schulze Matteo Cagiada | 2023 |
1208 A multimodal cytokine effects atlas from multiplexed cell barcoding reveals principles of T cell programming | Elisa C Clark Sriram Pendyala Kathleen Abadie Matthew Wither Arjun Kumar | 2023/11/1 |
