Donald M. O'Rourke

Donald M. O'Rourke

University of Pennsylvania

H-index: 65

North America-United States

About Donald M. O'Rourke

Donald M. O'Rourke, With an exceptional h-index of 65 and a recent h-index of 40 (since 2020), a distinguished researcher at University of Pennsylvania, specializes in the field of cancer biology, immunotherapy, brain cancer, neurosurgery, cancer therapeutics.

His recent articles reflect a diverse array of research interests and contributions to the field:

Brain-wide neuronal circuit connectome of human glioblastoma

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

Live Organoid Cyclic Imaging

Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach

1142 mRNA LNP vaccination with the tumor-specific antigen EGFRvIII bolsters CAR T cell activity in vivo

Distinguishing progression from pseudoprogression in glioblastoma using 18F-fluciclovine PET

Donald M. O'Rourke Information

University

Position

___

Citations(all)

15518

Citations(since 2020)

8610

Cited By

10101

hIndex(all)

65

hIndex(since 2020)

40

i10Index(all)

140

i10Index(since 2020)

106

Email

University Profile Page

University of Pennsylvania

Google Scholar

View Google Scholar Profile

Donald M. O'Rourke Skills & Research Interests

cancer biology

immunotherapy

brain cancer

neurosurgery

cancer therapeutics

Top articles of Donald M. O'Rourke

Title

Journal

Author(s)

Publication Date

Brain-wide neuronal circuit connectome of human glioblastoma

bioRxiv

Yusha Sun

Xin Wang

Daniel Y Zhang

Zhijian Zhang

Janardhan P Bhattarai

...

2024

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

bioRxiv

Nannan Li

Jesse L Rodriguez

Yibo Yin

Meghan T Logun

Shengkun Yu

...

2024

Live Organoid Cyclic Imaging

Advanced Science

David E Reynolds

Yusha Sun

Xin Wang

Phoebe Vallapureddy

Jianhua Lim

...

2024/2/7

Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results

Nature Medicine

Stephen J Bagley

Meghan Logun

Joseph A Fraietta

Xin Wang

Arati S Desai

...

2024/3/13

Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial

Nature Cancer

Stephen J Bagley

Zev A Binder

Lamia Lamrani

Eliana Marinari

Arati S Desai

...

2024/1/12

Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach

Scientific Reports

Jun Guo

Anahita Fathi Kazerooni

Erik Toorens

Hamed Akbari

Fanyang Yu

...

2024/2/28

1142 mRNA LNP vaccination with the tumor-specific antigen EGFRvIII bolsters CAR T cell activity in vivo

J Immunother

Jesse L Rodriguez

Tyler E Papp

Logan Zhang

Kelly A Hicks

Hamideh Parhiz

...

2023

Distinguishing progression from pseudoprogression in glioblastoma using 18F-fluciclovine PET

Journal of Nuclear Medicine

Ali Nabavizadeh

Stephen J Bagley

Robert K Doot

Jeffrey B Ware

Anthony J Young

...

2022/12/1

Optimizing CAR-T Therapy for Glioblastoma

Oliver Y Tang

Zev A Binder

Donald M O’Rourke

Stephen J Bagley

2023/11

Corrigendum to: EGFR, the Lazarus target for precision oncology in glioblastoma

Neuro-oncology

Benjamin Lin

Julia Ziebro

Erin Smithberger

Kasey R Skinner

Eva Zhao

...

2023/1

Abstract LB026: Porcine brain-derived hydrogel carriers for intratumoral administration of cellular immunotherapies enhances anti-tumor potential in post-resection GBM

Cancer Research

Meghan Logun

Zev Binder

Donald O'Rourke

2023/4/14

NIMG-13. ROBUSTNESS OF PROGNOSTIC STRATIFICATION IN DE NOVO GLIOBLASTOMA PATIENTS ACROSS 22 GEOGRAPHICALLY DISTINCT INSTITUTIONS: INSIGHTS FROM THE RESPOND CONSORTIUM

Neuro-Oncology

Hamed Akbari

Spyridon Bakas

Jose Garcia

Anahita Fathi Kazerooni

Chiharu Sako

...

2023/11/1

MODL-05. ELUCIDATING THE EPIGENETIC DRIVEN TRANSCRIPTIONAL PROGRAM UNDERLYING THE INVASIVE PHENOTYPE OF THE NOVEL EGFRA289VARIANT OF GBM

Neuro-Oncology

Benjamin Lin

Julia Ziebro

Abigail Shelton

Kasey Skinner

Ryan Bash

...

2023/11/1

Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI

Cancers

Laiz Laura de Godoy

Kheng Choon Lim

Archith Rajan

Gaurav Verma

Mauro Hanaoka

...

2023/9/7

Abstract LB097: Armored bicistronic CAR T cells with dominant-negative TGF-β receptor II to alleviate antigenic heterogeneity and suppressive immune microenvironment in …

Cancer Research

Nannan Li

Jesse Rodriguez

Zev Binder

Donald O’Rourke

2023/4/14

NIMG-39. BENCHMARKING MULTI-LABEL PREDICTION OF TARGET GENE MUTATION STATUS IN GLIOBLASTOMA USING RADIOGENOMICS AND MULTI-PARAMETRIC MR IMAGING

Neuro-Oncology

Fanyang Yu

Jun Guo

Anahita Fathi Kazerooni

Hamed Akbari

Erik Toorens

...

2023/11/1

Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric mri-based prediction model

Journal of Neuro-Oncology

Laiz Laura de Godoy

Sanjeev Chawla

Steven Brem

Sumei Wang

Donald M O’Rourke

...

2023/5

Non-invasive Assessment of IDH-mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI

Laiz Laura De Godoy

Kheng Choon Lim

Archith Rajan

Gaurav Verma

Mauro Hanaoka

...

2023/8/21

282 Dual antigen targeting CAR T cells armored with a dominant-negative TGF-β Receptor II enhance antitumor potency by overcoming TGF-β immunosuppression in GBM

Nannan Li

Jesse Rodriguez

Zev Binder

Donald O’Rourke

2023/11/1

Phase I study of repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab in patients with newly diagnosed, MGMT-unmethylated glioblastoma

Stephen J Bagley

Zev A Binder

Arati S Desai

Maclean P Nasrallah

Eileen Maloney

...

2023/3/28

See List of Professors in Donald M. O'Rourke University(University of Pennsylvania)

Co-Authors

H-index: 104
mark greene

mark greene

University of Pennsylvania

H-index: 66
Ramana V Davuluri

Ramana V Davuluri

Northwestern University

H-index: 50
Hui-Kuo Shu

Hui-Kuo Shu

Emory University

H-index: 40
Hongtao Zhang

Hongtao Zhang

University of Pennsylvania

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