David M. Bedwell
University of Alabama at Birmingham
H-index: 49
North America-United States
Top articles of David M. Bedwell
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Gene-targeted therapy for neurofibromatosis and schwannomatosis: the path to clinical trials | Clinical Trials | Verena Staedtke Kara Anstett David Bedwell Marco Giovannini Kim Keeling | 2024/2 |
Extended stop codon context predicts nonsense codon readthrough efficiency in human cells | Nature Communications | Kotchaphorn Mangkalaphiban Lianwu Fu Ming Du Kari Thrasher Kim M Keeling | 2024/3/20 |
Triamterene Functions as an Effective Nonsense Suppression Agent for MPS IH (Hurler Syndrome) | International Journal of Molecular Sciences | Amna Siddiqui Halil Dundar Jyoti Sharma Aneta Kaczmarczyk Josh Echols | 2023/2/24 |
266 eRF1 degrader SRI-41315 triggers the ribosome quality control E3 ligase network | Journal of Cystic Fibrosis | K Thrasher J Ekstrom K Keeling D Bedwell | 2023/10/1 |
268 Identifying the amino acid (s) inserted upon premature termination codon readthrough and their effect on CFTR functionality | Journal of Cystic Fibrosis | K Thrasher J Chen L Fu X Xue D Benson | 2023/10/1 |
Uracil Derivatives for Stimulating Read-Through of Premature Termination Codons | 2023/12/28 | ||
Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1 | Molecular Therapy-Nucleic Acids | Sara H Osum Eunice I Oribamise Stanislas MAS Corbière Mandy Taisto Tyler Jubenville | 2023/9/12 |
Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells | Plos one | Chao Li Zhong Liu Justin Anderson Zhongyu Liu Liping Tang | 2023/11/29 |
Translational Physiology: The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators | American Journal of Physiology-Lung Cellular and Molecular Physiology | Jianguo Chen Kari Thrasher Lianwu Fu Wei Wang Soheil Aghamohammadzadeh | 2023/6/6 |
271 Synergistic effects on readthrough of G542X CFTR by combining eRF1 and eRF3 degraders | Journal of Cystic Fibrosis | M Du Y Dai L Fu J Tillotson C Augelli-Szafran | 2023/10/1 |
The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators | American Journal of Physiology-Lung Cellular and Molecular Physiology | Jianguo Chen Kari Thrasher Lianwu Fu Wei Wang Soheil Aghamohammadzadeh | 2023/6/1 |
318 Novel eRF3 degrader monotherapy induces translational readthrough of CFTR nonsense mutations at therapeutically relevant levels | Journal of Cystic Fibrosis | S Rowe J Chen B Mathew O Moukha-Chafiq J Tillotson | 2023/10/1 |
Analysis of patient‐specific NF1 variants leads to functional insights for Ras signaling that can impact personalized medicine | Human Mutation | Ashlee Long Hui Liu Jian Liu Michael Daniel David M Bedwell | 2022/1 |
691 Synthetic aminoglycoside ELX-02 induces readthrough of cystic fibrosis transmembrane conductance regulator–G550X, producing super-functional protein that can be further … | Journal of Cystic Fibrosis | J Chen K Thrasher L Fu W Wang S Aghamohammadzadeh | 2022/10/1 |
645 A novel eRF1 degrader induces translational readthrough of cystic fibrosis transmembrane conductance regulator nonsense mutations to therapeutically relevant levels in … | Journal of Cystic Fibrosis | S Rowe J Chen M Du Y Li N Peng | 2022/10/1 |
613 Understanding synergy in nonsense suppression therapy for cystic fibrosis transmembrane conductance regulator nonsense mutations | Journal of Cystic Fibrosis | D Bedwell M Du J Yoon J Sharma V Mutyma | 2022/10/1 |
Targeted therapeutics for rare disorders | Kim M Keeling Andre Leier David M Bedwell Ann T Chen Robert A Kesterson | 2022/1/1 | |
671: Generation and characterization of a patient-derived iPSC line carrying the CFTR G542X/G542X mutation | Journal of Cystic Fibrosis | Z Liu C Zhang C Li S Rowe D Bedwell | 2021/11/1 |
531: Identification of a compound that mediates readthrough of CFTR nonsense mutations by reducing eRF1 levels | Journal of Cystic Fibrosis | D Bedwell J Sharma M Du E Wong V Mutyam | 2021/11/1 |
Compositions and methods for suppressing nonsense mutations | 2021/8/12 |
Co-Authors
