David Leys

David Leys

Manchester University

H-index: 65

North America-United States

About David Leys

David Leys, With an exceptional h-index of 65 and a recent h-index of 39 (since 2020), a distinguished researcher at Manchester University, specializes in the field of Structural biology, Enzymology, Synthetic biology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Photocobilins integrate B12 and bilin photochemistry for enzyme control

The prFMNH2-binding chaperone LpdD assists UbiD decarboxylase activation

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

Prenylated flavins: structures and mechanisms

High‐Titer Bio‐Styrene Production Afforded by Whole‐Cell Cascade Biotransformation

Stability engineering of ferulic acid decarboxylase unlocks enhanced aromatic acid decarboxylation

Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase

Redox driven B12-ligand switch drives CarH photoresponse

David Leys Information

University

Position

Professor in Structural Biology

Citations(all)

11314

Citations(since 2020)

4669

Cited By

8734

hIndex(all)

65

hIndex(since 2020)

39

i10Index(all)

151

i10Index(since 2020)

117

Email

University Profile Page

Manchester University

Google Scholar

View Google Scholar Profile

David Leys Skills & Research Interests

Structural biology

Enzymology

Synthetic biology

Top articles of David Leys

Title

Journal

Author(s)

Publication Date

Photocobilins integrate B12 and bilin photochemistry for enzyme control

Nigel Scrutton

Shaowei Zhang

Harshwardhan Poddar

Yuqi Yu

Chuanyang Liu

...

2023/5/30

The prFMNH2-binding chaperone LpdD assists UbiD decarboxylase activation

Journal of Biological Chemistry

Deepankar Gahloth

Karl Fisher

Stephen Marshall

David Leys

2024/2/1

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

Chemistry–A European Journal

Mona M Katariya

Matthew Snee

Richard B Tunnicliffe

Madeline E Kavanagh

Helena IM Boshoff

...

2023/5/22

Prenylated flavins: structures and mechanisms

Samuel Bloor

Iaroslav Michurin

Gabriel R Titchiner

David Leys

2023/5

High‐Titer Bio‐Styrene Production Afforded by Whole‐Cell Cascade Biotransformation

ChemCatChem

Hanan L Messiha

Nigel S Scrutton

David Leys

2023/3/8

Stability engineering of ferulic acid decarboxylase unlocks enhanced aromatic acid decarboxylation

Current Research in Chemical Biology

George W Roberts

Karl Fisher

Thomas Jowitt

David Leys

2023/1/1

Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase

Journal of Biological Chemistry

Karl Fisher

Tom Halliwell

Karl AP Payne

Gabriel Ragala

Sam Hay

...

2023/9/1

Redox driven B12-ligand switch drives CarH photoresponse

Nature Communications

Harshwardhan Poddar

Ronald Rios-Santacruz

Derren J Heyes

Muralidharan Shanmugam

Adam Brookfield

...

2023/8/21

A guide to time‐resolved structural analysis of light‐activated proteins

Harshwardhan Poddar

Derren J Heyes

Giorgio Schirò

Martin Weik

David Leys

...

2022/2

Structural insights into UbiD reversible decarboxylation

George W Roberts

David Leys

2022/8/1

A vitamin B2-photocatalysed approach to methionine analogues.

Oliver J Knowles&Nbsp

Linus O Johannissen

Giacomo EM Crisenza

Sam Hay

David Leys

...

2022

Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation

Catalysts

Gabriel R Titchiner

Stephen A Marshall

Herkus Miscikas

David Leys

2022/5/14

Heterologous production and biophysical characterization of catabolic Nitratireductor pacificus pht-3B reductive dehalogenase

Tom Halliwell

Karl Fisher

Stephen EJ Rigby

David Leys

2022/1/1

Enzymatic N-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases

ACS Sustainable Chemistry & Engineering

Godwin A Aleku

Gabriel R Titchiner

George W Roberts

Sasha R Derrington

James R Marshall

...

2022/5/6

Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase

Chetan A Patil

Jeroen Kalkman

Dirk Faber

John S Penn

Ton G van Leeuwen

...

2010/3/2

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening …

European Journal of Medicinal Chemistry

Martyn Frederickson

Irwin R Selvam

Dimitrios Evangelopoulos

Kirsty J McLean

Mona M Katariya

...

2022/2/15

A Vitamin B2‐Photocatalysed Approach to Methionine Analogues

Angewandte Chemie International Edition

Oliver J Knowles

Linus O Johannissen

Giacomo EM Crisenza

Sam Hay

David Leys

...

2022/12/12

Heterologous expression of cobalamin dependent class-III enzymes

Protein expression and purification

Tom Halliwell

Karl Fisher

Karl AP Payne

Stephen EJ Rigby

David Leys

2021/1/1

Methods of producing 2, 5-furandicarboxylic acid

2021/6/17

Synthetic Enzyme‐Catalyzed CO2 Fixation Reactions

Godwin A Aleku

George W Roberts

Gabriel R Titchiner

David Leys

2021/4/22

See List of Professors in David Leys University(Manchester University)