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Charlie Hatton

Charlie Hatton

Harvard University

H-index: 26

North America-United States

Contact Charlie Hatton

About Charlie Hatton

Charlie Hatton, With an exceptional h-index of 26 and a recent h-index of 23 (since 2020), a distinguished researcher at Harvard University,

His recent articles reflect a diverse array of research interests and contributions to the field:

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML

MEN1 mutations mediate clinical resistance to menin inhibition

Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

KDM6A epigenetically regulates subtype plasticity in small cell lung cancer

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A

Exploring the novel function of mutant NPM1 on chromatin

Charlie Hatton Information

University

Position

Dana-Farber Cancer Institute

Citations(all)

16158

Citations(since 2020)

7326

Cited By

12133

hIndex(all)

26

hIndex(since 2020)

23

i10Index(all)

32

i10Index(since 2020)

30

Email

University Profile Page

Google Scholar

Top articles of Charlie Hatton

Mezigdomide is effective alone and in combination with menin inhibition in preclinical models of KMT2A-r and NPM1c AML

Blood Journal

2023/12/14

Eric S Fischer
Eric S Fischer

H-Index: 25

MEN1 mutations mediate clinical resistance to menin inhibition

Nature

2023/3/30

Jeonghyeon Kim
Jeonghyeon Kim

H-Index: 5

Homa Rahnamoun
Homa Rahnamoun

H-Index: 5

Christian Marinaccio
Christian Marinaccio

H-Index: 9

Charlie Hatton
Charlie Hatton

H-Index: 22

David Schaller
David Schaller

H-Index: 5

Andrea Volkamer
Andrea Volkamer

H-Index: 12

Eric S Fischer
Eric S Fischer

H-Index: 25

Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia

Cancer discovery

2023/3/1

Charlie Hatton
Charlie Hatton

H-Index: 22

Christian Marinaccio
Christian Marinaccio

H-Index: 9

Lu Yang
Lu Yang

H-Index: 2

Lorenzo Brunetti
Lorenzo Brunetti

H-Index: 16

Chun-Wei Chen
Chun-Wei Chen

H-Index: 2

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Clinical Cancer Research

2023/11/14

Jonathan Paolino
Jonathan Paolino

H-Index: 3

Angelica Sandoval-Perez
Angelica Sandoval-Perez

H-Index: 4

Yuting Li
Yuting Li

H-Index: 5

Charlie Hatton
Charlie Hatton

H-Index: 22

KDM6A epigenetically regulates subtype plasticity in small cell lung cancer

Nature Cell Biology

2023/9

Yixiang Li
Yixiang Li

H-Index: 8

Yingtian Xie
Yingtian Xie

H-Index: 7

Deli Hong
Deli Hong

H-Index: 14

Charlie Hatton
Charlie Hatton

H-Index: 22

Emily Walton
Emily Walton

H-Index: 15

Rong Li
Rong Li

H-Index: 7

Sabina Signoretti
Sabina Signoretti

H-Index: 76

Xintao Qiu
Xintao Qiu

H-Index: 13

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Molecular Cell

2023/8/3

Yen-Der Li
Yen-Der Li

H-Index: 3

Katherine A Donovan
Katherine A Donovan

H-Index: 16

Charlie Hatton
Charlie Hatton

H-Index: 22

Jeonghyeon Kim
Jeonghyeon Kim

H-Index: 5

Peter G Miller
Peter G Miller

H-Index: 31

Eric S Fischer
Eric S Fischer

H-Index: 25

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A

HemaSphere

2023/8/1

Homa Rahnamoun
Homa Rahnamoun

H-Index: 5

Charlie Hatton
Charlie Hatton

H-Index: 22

Exploring the novel function of mutant NPM1 on chromatin

Klinische Pädiatrie

2023/5

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

Blood

2022/11/15

Eric Wong
Eric Wong

H-Index: 8

Christian Marinaccio
Christian Marinaccio

H-Index: 9

Lorenzo Brunetti
Lorenzo Brunetti

H-Index: 16

UBR5 Is a Hect E3 Ubiquitin Ligase That Regulates Chromatin Bound Nuclear Hormone Receptor Stability

Blood

2022/11/15

Yen-Der Li
Yen-Der Li

H-Index: 3

Katherine Donovan
Katherine Donovan

H-Index: 5

Paul Park
Paul Park

H-Index: 37

Charlie Hatton
Charlie Hatton

H-Index: 22

Mikolaj Slabicki
Mikolaj Slabicki

H-Index: 16

Peter G Miller
Peter G Miller

H-Index: 31

Eric S Fischer
Eric S Fischer

H-Index: 25

MOZ and Menin–MLL complexes are complementary regulators of chromatin association and transcriptional output in gastrointestinal stromal tumor

Cancer discovery

2022/7/6

Charlie Hatton
Charlie Hatton

H-Index: 22

Ewa Sicinska
Ewa Sicinska

H-Index: 6

Targeted MLL-AF9 degradation is phenocopied by combined DOT1L and Menin inhibition

Cancer Research

2022/6/15

Laura Godfrey
Laura Godfrey

H-Index: 7

S115: MUTANT NPM1 BINDS CHROMATIN AND COOPERATES WITH MLL1 TO REGULATE ONCOGENIC TRANSCRIPTION

HemaSphere

2022/6/1

Hannah Uckelmann
Hannah Uckelmann

H-Index: 7

Scott Armstrong
Scott Armstrong

H-Index: 5

Eric Wong
Eric Wong

H-Index: 8

Christian Marinaccio
Christian Marinaccio

H-Index: 9

IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia

Nature cancer

2022/5

Katherine A Donovan
Katherine A Donovan

H-Index: 16

Charlie Hatton
Charlie Hatton

H-Index: 22

Homa Rahnamoun
Homa Rahnamoun

H-Index: 5

Qian Zhu
Qian Zhu

H-Index: 12

Young Joon Kim
Young Joon Kim

H-Index: 6

Anthony Letai
Anthony Letai

H-Index: 64

Eric S Fischer
Eric S Fischer

H-Index: 25

MLL:: AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

Molecular cell

2022/3/17

Laura Godfrey
Laura Godfrey

H-Index: 7

Yan Kai
Yan Kai

H-Index: 9

Guo-Cheng Yuan
Guo-Cheng Yuan

H-Index: 51

The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML

Blood, The Journal of the American Society of Hematology

2022/2/10

YBX1 mediates translation of oncogenic transcripts to control cell competition in AML

Leukemia

2022/2

Maximilian Hartmann
Maximilian Hartmann

H-Index: 2

Potent Ikaros degradation by the cereblon E3 ligase modulator CC-92480 is effective in combination with Menin-MLL1 inhibition in MLL1-rearranged and NPM1-mutant AML

Blood

2021/11/23

Katherine A Donovan
Katherine A Donovan

H-Index: 16

Eric S Fischer
Eric S Fischer

H-Index: 25

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

Blood, The Journal of the American Society of Hematology

2020/10/22

Andreas Weiss
Andreas Weiss

H-Index: 9

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia

Science

2020/1/31

Lars Bullinger
Lars Bullinger

H-Index: 62

See List of Professors in Charlie Hatton University(Harvard University)