Andrew D. Mesecar
Purdue University
H-index: 69
North America-United States
Top articles of Andrew D. Mesecar
Title | Journal | Author(s) | Publication Date |
|---|---|---|---|
Compounds for the treatment of sars | 2024/2/8 | ||
A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes | Plos one | Ramya Visvanathan Tadanobu Utsuki Daniel E Beck W Brent Clayton Emma Lendy | 2024/3/29 |
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors | European Journal of Medicinal Chemistry | Arun K Ghosh Monika Yadav Satyanarayana Iddum Somayeh Ghazi Emma K Lendy | 2024/3/5 |
pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography | Biophysical Journal | Vatsal Purohit Calvin N Steussy Anthony R Rosales Chandra J Critchelow Tim Schmidt | 2024/2/6 |
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads | Bioorganic & Medicinal Chemistry Letters | Arun K Ghosh Dana Shahabi Mackenzie EC Imhoff Satish Kovela Ashish Sharma | 2023/11/15 |
6-amino-2, 4-dihydropyrano [2, 3-c] pyrazoles and methods of use | 2023/4/4 | ||
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease | Alzheimer's & Dementia: Translational Research & Clinical Interventions | Cynthia D Jesudason Emily R Mason Shaoyou Chu Adrian L Oblak June Javens‐Wolfe | 2023/10 |
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor | Communications Biology | Sucharita Bose C Nicklaus Steussy Daneli López-Pérez Tim Schmidt Samadhi C Kulathunga | 2023/4/3 |
Development of a sensitive microplate assay for characterizing RNA methyltransferase activity: Implications for epitranscriptomics and drug development | Journal of Biological Chemistry | Isaiah K Mensah Allison B Norvil Ming He Emma Lendy Nicole Hjortland | 2023/10/1 |
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease | Immunity | Andy P Tsai Chuanpeng Dong Peter Bor-Chian Lin Adrian L Oblak Gonzalo Viana Di Prisco | 2023/9/12 |
A target enablement package for modulating the activity of PLCγ2 as a therapeutic strategy for the treatment of Alzheimer’s disease | Alzheimer's & Dementia | Brent Clayton Stephanie J Bissel Timothy I Richardson Steven M Massey Daniel E Beck | 2023/12 |
A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators … | SLAS Discovery | Ramya Visvanathan Tadanobu Utsuki Daniel E Beck Emma Lendy Kuai-lin Sun | 2023/6/1 |
Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19 | Arun K Ghosh Jennifer L Mishevich Andrew Mesecar Hiroaki Mitsuya | 2022/11/18 | |
Desorption electrospray ionization mass spectrometry assay for label‐free characterization of SULT2B1b enzyme kinetics | Journal of the American Society for Mass Spectrometry | Jephte Yao Akakpo Matthew Wolfgang Jaeschke Yasaman Etemadi Antonio Artigues Scott Toerber | 2022/10/12 |
Exploring the structural determinants for inhibitor selectivity towards the BACE protein family using structure-based molecular design | Biophysical Journal | Emma K Lendy Yu-Chen Yen Emilio L Cardenas Margherita Brindisi Arun K Ghosh | 2022/2/11 |
Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease | bioRxiv | Andy P Tsai Chuanpeng Dong Peter Bor-Chian Lin Adrian L Oblak Gonzalo Viana Di Prisco | 2022/12/9 |
Bace1 inhibitors for the treatment of alzheimer's disease | 2022/12/8 | ||
Characterization of human sulfotransferase 1A1 (SULT1A1) as a new target for structure-based design of drugs to treat cancer | Biophysical Journal | Samadhi C Kulathunga Qing Zhou Nicolás M Morato R Graham Cooks Andrew D Mesecar | 2022/2/11 |
Catalytic function and substrate specificity of alpha and beta coronavirus papain-like proteases: targeting human NL63, SARS-CoV and SARS-CoV-2 (Covid-19) with designed inhibitors | Biophysical Journal | Mackenzie E Chapman Courtney M Daczkowski Arun K Ghosh Andrew D Mesecar | 2022/2/2 |
A target enablement package for the inhibition of SHIP1 as a therapeutic strategy for the treatment of Alzheimer’s disease | Alzheimer's & Dementia | Timothy I Richardson Cynthia D Jesudason Karen L Lobb Gregory L Durst Brent Clayton | 2022/12 |
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