Amedeo Caflisch

Amedeo Caflisch

Universität Zürich

H-index: 85

Europe-Switzerland

About Amedeo Caflisch

Amedeo Caflisch, With an exceptional h-index of 85 and a recent h-index of 42 (since 2020), a distinguished researcher at Universität Zürich, specializes in the field of Molecular dynamics, drug design.

His recent articles reflect a diverse array of research interests and contributions to the field:

Development of a novel class of CBP/EP300 bromodomain inhibitors which block TNF-α induced NFκB signaling

The catalytic mechanism of the RNA methyltransferase METTL3

Proteolysis Targeting Chimera Degraders of the METTL3–14 m6A-RNA Methyltransferase

AI is a viable alternative to high throughput screening: a 318-target study

Structure-based Design of CBP/EP300 Degraders: When Coopera-tivity Overcomes Affinity

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors

Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations

Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

Amedeo Caflisch Information

University

Position

Department of Biochemistry

Citations(all)

28555

Citations(since 2020)

9742

Cited By

22659

hIndex(all)

85

hIndex(since 2020)

42

i10Index(all)

238

i10Index(since 2020)

142

Email

University Profile Page

Universität Zürich

Google Scholar

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Amedeo Caflisch Skills & Research Interests

Molecular dynamics

drug design

Top articles of Amedeo Caflisch

Title

Journal

Author(s)

Publication Date

Development of a novel class of CBP/EP300 bromodomain inhibitors which block TNF-α induced NFκB signaling

Katherine Gosselé

Irene Latino

Eleen Laul

Mariia Kirillova

Vlad Pascanu

...

2024/3/26

The catalytic mechanism of the RNA methyltransferase METTL3

eLife

Ivan Corbeski

Pablo Andrés Vargas-Rosales

Rajiv Kumar Bedi

Jiahua Deng

Dylan Coelho

...

2023/11/30

Proteolysis Targeting Chimera Degraders of the METTL3–14 m6A-RNA Methyltransferase

JACS Au

Francesco Errani

Annalisa Invernizzi

Marcin Herok

Elena Bochenkova

Fiona Stamm

...

2024/2/12

AI is a viable alternative to high throughput screening: a 318-target study

Scientific Reports

2024/4/2

Structure-based Design of CBP/EP300 Degraders: When Coopera-tivity Overcomes Affinity

Iván Cheng-Sánchez

Katherine Gosselé

Leonardo Palaferri

Eleen Laul

Gionata Riccabella

...

2024/3/26

Exploring the Binding Pathway of Novel Nonpeptidomimetic Plasmepsin V Inhibitors

J. Chem. Inf. Model.

Kristaps Jaudzems Raitis Bobrovs

Laura Drunka

Iveta Kanepe

Aigars Jirgensons

Amedeo Caflisch

...

2023/10/6

Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations

Journal of Chemical Information and Modeling

Ioana M Ilie

Claus Ehrhardt

Amedeo Caflisch

Gabriele Weitz-Schmidt

2023/6/13

Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

Brain Pathology

Regina R Reimann

Martina Puzio

Antonella Rosati

Marc Emmenegger

Bernard L Schneider

...

2023/3

Reevaluation of bromodomain ligands targeting BAZ2A

Protein Science

Giulia Cazzanelli

Andrea Dalle Vedove

Eleonora Parolin

Vito Giuseppe D'Agostino

Andrea Unzue

...

2023/9

Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

International journal of biological macromolecules

Yusen Xiang

Guanglei Zhai

Yaozong Li

Mengge Wang

Xixiang Chen

...

2023/1/31

Disrupting dimeric β-amyloid by electric fields

ACS Physical Chemistry Au

Pablo Andrés Vargas-Rosales

Alessio D’Addio

Yang Zhang

Amedeo Caflisch

2023/7/12

Small-molecule inhibitors of the m7G-RNA writer METTL1

ACS Bio & Med Chem Au

Francesco Nai

Maria Paula Flores Espinoza

Annalisa Invernizzi

Pablo Andrés Vargas-Rosales

Olga Bobileva

...

2023/12/12

Optimized reaction coordinates for analysis of enhanced sampling

The Journal of Chemical Physics

Julian Widmer

Cassiano Langini

Andreas Vitalis

Amedeo Caflisch

2023/7/7

Structure-based design of a potent and selective YTHDC1 ligand

František Zálešák

Francesco Nai

Rajiv K Bedi

Yaozong Li

Marcin Herok

...

2023/11/29

Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3

ACS bio & med chem Au

Rajiv Kumar Bedi

Danzhi Huang

Yaozong Li

Amedeo Caflisch

2023/6/14

Antibody binding modulates the dynamics of the membrane-bound prion protein

Biophysical Journal

Ioana M Ilie

Marco Bacci

Andreas Vitalis

Amedeo Caflisch

2022/7/19

Domino effect in allosteric signaling of peptide binding

Journal of Molecular Biology

Pablo Andrés Vargas-Rosales

Amedeo Caflisch

2022/9/15

Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

Journal of Biological Chemistry

Johannes Schilling

Christian Jost

Ioana Mariuca Ilie

Joachim Schnabl

Oralea Buechi

...

2022/1/1

Silybins inhibit human IAPP amyloid growth and toxicity through stereospecific interactions

Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics

Sara García-Viñuales

Ioana M Ilie

Anna Maria Santoro

Valeria Romanucci

Armando Zarrelli

...

2022/5/1

Identification of BAZ2A bromodomain hit compounds

Acta Crystallographica Section A: Foundations and Advances

A Dalle Vedove

G Cazzanelli

J Corsi

M Sedykh

L Batiste

...

2022/8/23

See List of Professors in Amedeo Caflisch University(Universität Zürich)

Co-Authors

H-index: 134
Andreas Pluckthun

Andreas Pluckthun

Universität Zürich

H-index: 94
Ehud Gazit

Ehud Gazit

Tel Aviv University

H-index: 77
Peter Hamm

Peter Hamm

Universität Zürich

H-index: 50
Emanuele Paci

Emanuele Paci

University of Leeds

H-index: 47
Oliver Zerbe

Oliver Zerbe

Universität Zürich

H-index: 31
Peter Kolb

Peter Kolb

Philipps-Universität Marburg

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