Alex K. Shalek

Alex K. Shalek

Massachusetts Institute of Technology

H-index: 67

North America-United States

About Alex K. Shalek

Alex K. Shalek, With an exceptional h-index of 67 and a recent h-index of 65 (since 2020), a distinguished researcher at Massachusetts Institute of Technology, specializes in the field of single-cell genomics, micro- and nanotechnology, infectious diseases, cancer, autoimmunity.

His recent articles reflect a diverse array of research interests and contributions to the field:

B-cell-directed CAR-T cell therapy activates CD8+ cytotoxic CARneg bystander T-cells in non-human primates and patients

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity

Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection

A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing

Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Abstract A078: Response and resistance to KRAS inhibition in PDAC mouse models

Dissecting tumor-immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

Alex K. Shalek Information

University

Position

___

Citations(all)

42870

Citations(since 2020)

33533

Cited By

21601

hIndex(all)

67

hIndex(since 2020)

65

i10Index(all)

142

i10Index(since 2020)

141

Email

University Profile Page

Massachusetts Institute of Technology

Google Scholar

View Google Scholar Profile

Alex K. Shalek Skills & Research Interests

single-cell genomics

micro- and nanotechnology

infectious diseases

cancer

autoimmunity

Top articles of Alex K. Shalek

Title

Journal

Author(s)

Publication Date

B-cell-directed CAR-T cell therapy activates CD8+ cytotoxic CARneg bystander T-cells in non-human primates and patients

Blood

James Kaminski

Ryan A Fleming

Francesca Alvarez-Calderon

Marlana B Winschel

Connor McGuckin

...

2024/4/3

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity

bioRxiv

Valerie Lensch

Adele Gabba

Robert Hincapie

Sachin H Bhagchandani

Ankit Basak

...

2024

Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection

Genome Medicine

Aaron J Wilk

Joshua O Marceau

Samuel W Kazer

Ira Fleming

Vincent N Miao

...

2024/2/5

A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing

bioRxiv

Alan DenAdel

Michelle L Ramseier

Andrew W Navia

Alex K Shalek

Srivatsan Raghavan

...

2024

Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Cancer Research

Julien Dilly

Laleh Abbassi

Connor J Hennessey

Giselle A Uribe

Brendan Parent

...

2024/3/22

Abstract A078: Response and resistance to KRAS inhibition in PDAC mouse models

Cancer Research

Laleh Abbassi

Jullien Dilly

Annan Yang

Giselle Uribe

Branden Parent

...

2024/1/16

Dissecting tumor-immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma

Cancer Research

Giuseppe Tarantino

Yiwen He

Priyanka Solanky

Aaron Thorner

Tyler Aprati

...

2024/3/22

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

bioRxiv

Yao Yu Yeo

Huaying Qiu

Yunhao Bai

Bokai Zhu

Yuzhou Chang

...

2024

Abstract C058: Identifying cell-intrinsic drivers of transcriptional plasticity in pancreatic cancer

Cancer Research

Yuzhou Evelyn Tong

Walaa E Katan

Alex Bott

Julia Joung

Alex K Shalek

...

2024/1/16

B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles

Rob Krause

Paul Ogongo

Liku Tezera

Mohamed Ahmed

Ian Mbano

...

2023/11/1

A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment

bioRxiv

Bokai Zhu

Yunhao Bai

Yao Yu Yeo

Xiaowei Lu

Xavier Rovira-Clavé

...

2024

An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection

Microbiology Spectrum

Carly GK Ziegler

Anna H Owings

Michelle Galeas-Pena

Samuel W Kazer

Vincent N Miao

...

2024/4/30

Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data

bioRxiv

Chibuikem Nwizu

Madeline Hughes

Michelle L Ramseier

Andrew Navia

Alex K Shalek

...

2024

Comparative analysis of cell–cell communication at single-cell resolution

Nature Biotechnology

Aaron J Wilk

Alex K Shalek

Susan Holmes

Catherine A Blish

2024/3

Abstract A093: Deciphering acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma

Cancer Research

Julien Dilly

Laleh Abbassi

Connor J Hennessey

Giselle A Uribe

Brendan Parent

...

2024/1/16

Methods of stratifying and treating coronavirus infection

2024/4/25

Congenital T cell activation impairs transitional to follicular B cell maturation in humans

bioRxiv

Hugues Allard-Chamard

Kirsty Hillier

Michelle L Ramseier

Alice Bertocchi

Naoki Kaneko

...

2024

Markers of active hiv reservoir

2023/10/10

Compositions and methods for treating bacterial infections

2024/1/9

Compressed phenotypic screens for complex multicellular models and high-content assays

bioRxiv

Benjamin E Mead

Conner Kummerlowe

Nuo Liu

Walaa E Kattan

Thomas Cheng

...

2023/1/23

See List of Professors in Alex K. Shalek University(Massachusetts Institute of Technology)