Abdelmaksoud A.H. Kamel

Abdelmaksoud A.H. Kamel

Cairo University

H-index: 14

Africa-Egypt

About Abdelmaksoud A.H. Kamel

Abdelmaksoud A.H. Kamel, With an exceptional h-index of 14 and a recent h-index of 12 (since 2020), a distinguished researcher at Cairo University, specializes in the field of Intervention Radiology.

His recent articles reflect a diverse array of research interests and contributions to the field:

Early Detection and prediction of survival of patients with Hepatocellular Carcinoma Using Transient Elastography

Role of Transient Elastography (Fibroscan) in Early prediction of Hepatitis C Virus Related Hepatocellular Carcinoma

Spontaneous vanishing of hepatocellular carcinoma: A case report of an extremely rare incident

Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma

Hepatic resection versus microwave ablation for the treatment of early hepatocellular carcinoma: a comparative analysis of treatment outcomes and survival predictors

Schistosoma mansoni infection and the occurrence, characteristics, and survival of patients with hepatocellular carcinoma: an observational study over a decade

Survival and recurrence rates of hepatocellular carcinoma after treatment of chronic hepatitis C using direct acting antivirals

Novel optical coherence tomography findings of a case of sympathetic ophthalmia after 23-gauge vitrectomy

Abdelmaksoud A.H. Kamel Information

University

Cairo University

Position

Department of Radiology

Citations(all)

886

Citations(since 2020)

692

Cited By

544

hIndex(all)

14

hIndex(since 2020)

12

i10Index(all)

15

i10Index(since 2020)

14

Email

University Profile Page

Cairo University

Abdelmaksoud A.H. Kamel Skills & Research Interests

Intervention Radiology

Top articles of Abdelmaksoud A.H. Kamel

Early Detection and prediction of survival of patients with Hepatocellular Carcinoma Using Transient Elastography

Authors

Mohamed B Hashem,Hend Ibrahim Shousha,Mohammed N Abou Hia Allah,Ashraf Omar Abdelaziz,Mohammed H Al-Nadry,Walid M Gomaa,Mohamed M Abdel-Halim,Mohamed Mahmoud Nabeel,Tamer Mahmoud Elbaz,Ahmed Hosni Abdelmaksoud,Hedy A Badary

Journal

African Journal of Gastroenterology and Hepatology

Published Date

2024/1/1

BackgroundDetection of early cases of HCC allows for offering curative interventions that may positively impact the survival of patients. Screening depends on the use of ultrasound with or without alpha-fetoprotein. However, some cases might need to be noticed, so alternatives are needed. Transient elastography can be studied as an effective alternative.MethodsPatients were divided into groups with liver cirrhosis and HCC and another group without HCC. Demographic criteria and laboratory profiles were compared. Transient elastography was then performed, and values of Controlled Attenuation Parameters (CAP) and liver stiffness were compared between both groups.ResultsOne hundred thirty-three patients with liver cirrhosis and HCC and 133 patients without HCC were studied. Our study showed that patients with HCC had significantly lower steatosis as measured by CAP using transient elastography (p-value < 0.001). However, they had substantially higher fibrosis (p-value < 0.001). A cutoff level of >24.3 Kpa showed a 90.5% sensitivity, 85.7% specificity, 86.4% PPV and 90% NPV for predicting the occurrence of HCC. By using univariate analysis, smoking was a significant predictor for mortality of HCC patients. In contrast, the multivariate analysis showed that gender was an independent predictor for mortality in patients with HCC. Liver stiffness measurement was not shown to predict survival in patients with HCC.ConclusionDetection of early HCC is essential to gain the utmost benefit from the available therapeutic options. Transient elastography may provide a tool for diagnosing patients in the early stages. However, it might not be a …

Role of Transient Elastography (Fibroscan) in Early prediction of Hepatitis C Virus Related Hepatocellular Carcinoma

Authors

Mohammed Nagy Mohammed,Mohammed Hassan Al-Nadry,Mohamed Mahmoud Abdel-halim,Ashraf Omar Abdelaziz,Rania Lithy,Ahmed Hosni Abdelmaksoud,Hend Ibrahim Shousha

Journal

Al-Azhar International Medical Journal

Published Date

2023/1/13

Background Hepatocellular carcinoma (HCC) is the fifth-leading cause of cancer-related deaths globally. Liver biopsy is the gold standard for diagnosing liver fibrosis and cirrhosis. Instead of a liver biopsy, a number of noninvasive diagnostic tools for assessing hepatic fibrosis as a risk factor for HCC, such as fibroscan. Aim of work Assess the role of Transient Elastography (Fibroscan) in prediction of (HCC) in chronic hepatitis C virus patients. Subjects and methods A case-control study included 133 patients with cirrhosis and HCC and 133 patients with HCV-Liver cirrhosis without HCC was carried out. Each patient had their medical history taken, and thorough clinical examination, they were assessed for liver stiffness using fibroscan, all patients underwent Triphasic CT scan, routine laboratory investigations were taken from each patient as liver function test, CBC and tumor markers. Results Males resembled the majority and patients with HCC were significantly older than those without HCC (p-value < 0.001). Our data showed that sensitivity analysis of liver stiffness measured by transient elastography (FibroScan) can be used to discriminate between cirrhotic group without HCC and HCC group at a cutoff level of > 24.3, with 90.5% sensitivity, 85.7% specificity, 86.4% PPV and 90% NPV (AUC = 0.941 & p-value less than 0.001). Conclusion Fibroscan can significantly predict HCC among patients post-HCV treatment using cutoff point of liver stiffness > 24.3 kPa.

Spontaneous vanishing of hepatocellular carcinoma: A case report of an extremely rare incident

Authors

Mohamed El-Kassas,Reem Y El Sheemy,Ahmad T Sweedy,Ahmed Hosni Abdelmaksoud

Journal

Journal of Cancer Research and Therapeutics

Published Date

2023/7/1

One of the very uncommon clinical conditions is the spontaneous remission of tumors, with scarce reports around the world in various types of tumors. Spontaneous remission of hepatocellular carcinoma (HCC) is extremely rare, but it is well documented with a still unclear underlying mechanism. In this case report, we present one of those exceptional incidents of HCC regression with a trial to tackle possible explanations. Our case, which has a history of successfully treated hepatitis C virus, presented with a large infiltrative right lobar mass invading the main portal vein, with markedly elevated alpha fetoprotein (AFP). According to the applied diagnostic and treatment guidelines, the patient was scheduled for conservative management. Although he did not receive any specific treatments for his condition, the mass regressed in size with recanalization of the portal vein and normalization of AFP after 6 months of follow …

Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma

Authors

Rania M Lithy,Ashraf Omar Abdelaziz,Abobakr Awad,Hend Ibrahim Shousha,Dalia Omran,Mohamed Mahmoud Nabil,Ahmed Hosni Abdelmaksoud,Tamer Mahmoud Elbaz,Mahasen Mabrouk

Journal

Arab Journal of Gastroenterology

Published Date

2022/11/1

Background and study aimsPrediction of prognosis and treatment outcomes for patients with hepatocellular carcinoma (HCC) is complex for most patients. Machine learning predictive analysis can be used to explore the rich information in electronic health records to discover hidden patterns and relationships. We aimed to develop a noninvasive algorithm for predicting outcome treatment options for patients with HCC.Patients and methodsThis cross-sectional study included 1298 patients with Hepatitis C virus-related HCC attending an HCC multidisciplinary clinic, Kasr Al-Aini Hospital, Cairo University, between 2009 and 2016. Using machine learning analysis, we constructed Reduced Error Pruning (REP) decision tree algorithms and applied Auto-WEKA to select the best classifier out of 39 algorithms.ResultsThe REP-tree algorithm predicted HCC management outcomes with a recall (sensitivity) of 0.658 and a …

Hepatic resection versus microwave ablation for the treatment of early hepatocellular carcinoma: a comparative analysis of treatment outcomes and survival predictors

Authors

Ayman MA Osman,Ashraf Omar Abdelaziz,Mahmoud Deweir,Ayman Salah,Shady Tarek Elghazaly Harb,Mohamed Mahmoud Nabeel,Ahmed Hosni Abdelmaksoud,Hend Ibrahim Shousha,Tamer Mahmoud Elbaz,Mohamed B Hashem

Journal

Egyptian Liver Journal

Published Date

2022/8/23

IntroductionLiver resection and local ablation are the two primary curative treatments for early-stage hepatocellular carcinoma (HCC). Microwave ablation (MWA) shows promising performance in terms of early tumor response, recurrence, and survival. This study aims to determine whether MWA would be comparable to liver resection in treating early-stage HCC.MethodsThis study included patients with hepatitis C-related HCC attending the multidisciplinary HCC clinic, Kasr Al-Ainy Hospital (March 2018 to September 2020). We included adults with early-stage HCC (BCLC stages 0-A). We studied patients and tumor characteristics, HCC treatment response, recurrence, and overall survival.ResultsThirty-one patients were treated with liver resection and 41 patients were treated with MWA, including 4 patients who received intraoperative MWA. By the end of the study, 21 patients (28.77%) died. Patients who …

Schistosoma mansoni infection and the occurrence, characteristics, and survival of patients with hepatocellular carcinoma: an observational study over a decade

Authors

Hend Ibrahim Shousha,Ashraf Omar Abdelaziz,Mohamed Mahmoud Nabeel,Dalia Abdelhamid Omran,Ahmed Hosni Abdelmaksoud,Tamer Mahmoud Elbaz,Ayman Salah,Shady Tarek ElGhazaly Harb,Karim Adel Hosny,Ayman Osman,Mira Atef,Abdelazez Gaber,Naglaa Ali Zayed,Ayman Abdelhady Yosry,Rania Leithy

Journal

Pathogens and Global Health

Published Date

2022/2/17

Schistosoma mansoni infection (SMI) is suspected to be directly and indirectly involved in hepato-carcinogenesis. This study evaluated the association of a previous SMI with hepatocellular carcinoma (HCC) development, patients, tumor characteristics, treatment outcomes, and survival. This observational study included patients with HCC with and without previous SMI who presented to the multidisciplinary HCC clinic, Kasr-Alainy hospital (November 2009 to December 2019). It also included 313 patients with liver cirrhosis without HCC. Clinical and laboratory features of the patients (complete blood count, liver/renal functions , alpha-fetoprotein, and hepatitis B/C status), tumor characteristics (Triphasic CT and/or dynamic MRI), liver stiffness (transient elastography), HCC treatment outcome, and overall survival were studied. This study included 1446 patients with HCC; 688(47.6%) composed group-1, defined by …

Survival and recurrence rates of hepatocellular carcinoma after treatment of chronic hepatitis C using direct acting antivirals

Authors

Rania M Lithy,Tamer Elbaz,Ahmed H Abdelmaksoud,Mohamed M Nabil,Noha Rashed,Dalia Omran,Ahmed O Kaseb,Ashraf O Abdelaziz,Hend I Shousha

Journal

European Journal of Gastroenterology & Hepatology

Published Date

2022/2/1

BackgroundConflicting studies were proposed either suggested or denied the relationship between early hepatocellular carcinoma (HCC) recurrence and the use of direct-acting antivirals (DAAs) for chronic hepatitis C management

Novel optical coherence tomography findings of a case of sympathetic ophthalmia after 23-gauge vitrectomy

Authors

Ahmed Abdelmaksoud,Nigel Terk-Howe Khoo,Katharine Sears,Stephen Winder

Journal

Retinal Cases and Brief Reports

Published Date

2021/9/1

Purpose:Sympathetic ophthalmia (SO) is a rare panuveitis after trauma to one eye. We present a case of SO after 23-gauge transconjunctival vitrectomy, including optical coherence tomography evidence of response to treatment. To our knowledge, this is the first SO case report to include spectral domain optical coherence tomography images of Dalen-Fuchs nodules.Methods:Observational case report of a case of SO after two pars plana vitrectomies in the fellow eye.Results:A 67-year-old woman who had an operation for her pseudophakic left eye for a macula-off retinal detachment. She had two surgeries and later on had a total retinal detachment with vision of no perception of light. Eighteen months later, she presented back with a panuveitis with vitritis in her other eye and a visual acuity of 6/18. Dalen-Fuchs denoting SO was found. Treatment was commenced, and multimodal imaging was performed …

Hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma with portal vein thrombosis: a case–control study

Authors

AHK Abdelmaksoud,AO Abdelaziz,MM Nabeel,I Hamza,TM Elbaz,HI Shousha,RSM Abdelhady,R Lithy

Journal

Clinical Radiology

Published Date

2021/9/1

AIMTo study the treatment efficacy and survival of hepatic arterial infusion chemotherapy (HAIC) for patients with advanced hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT) with compensated cirrhosis in comparison with sorafenib as the standard of care therapy versus best supportive care (BSC).MATERIALS AND METHODSThis case–control study included 91 patients with advanced HCC and PVTT divided into three groups: Group 1 20 treated with HAIC, (50 mg adriamycin and 50 mg cisplatin were infused in hepatic artery); Group 2, 42 patients treated with BSC; and Group 3, 29 patients treated with sorafenib. Patients were followed up for assessment and comparison of treatment outcome by modified Response Evaluation Criteria in Solid Tumours (mRECIST) and survival.RESULTSThere was no significant difference among the groups studied regarding baseline demographic and …

Tumor Response and Factors Affecting Survival of Using Sorafenib in Management of Advanced Hepatocellular Carcinoma

Authors

Ahmed Ramadan,Tamer Mahmoud Elbaz,Ashraf Omar Abdelaziz,Mohamed Mahmoud Nabeel,Hend Ibrahim Shousha,Wafaa Elakel,Zeinab Soliman,Eman Medhat,Dalia Omran,Hedy A Badary,Ahmed Hosni Abdelmaksoud,Samar Samir Youssef

Journal

Biomedical Journal of Scientific & Technical Research

Published Date

2021

Purpose: Hepatocellular carcinoma (HCC) is a dismal tumor that is usually diagnosed at late stages. Sorafenib is the main line of treatment in advanced HCC cases while preserved hepatic functions. However, the drug has high costs and is associated with several side effects. We aimed to study the predictive factors for survival to limit patients with potential low response and exposure to side effects.Methods: This prospective cohort study included 64 patients with advanced HCC and who were treated using Sorafenib according to international guidelines. The modified Response evaluation criteria in solid tumors (RECIST) assessed treatment response and we did regression analysis for predictors of survival.Result: Our studied patients were predominantly males with mean age 59 years. They were Child A (48 patients) and Child B7 (16 patients). Lesions were large in size (mean 6.5 cm) and 50% had portal vein thrombosis. Stationary disease was recorded in 84.38% of patients with a mean duration of treatment 4.71 months and overall survival 11.25±7.25 months. Hand and foot syndrome was the most common adverse event. Multivariate regression analysis showed that performance status (HR: 2.96, CI:(1.22-7.21), P-value 0.02) and tumor size≥ 5cm (HR: 2.36, CI:(1.1-5.25) P-value 0.03) were the lone factors.Conclusion: We reported higher rates of stationary disease and good survival rates. The lone prognostic factors for survival were PS≥ 2 and size of lesions≥ 5 cm. Sorafenib is still a backbone treatment for advanced HCC patients till emergence of safer and more effective lines of treatment.

Predictors of recurrence and survival of hepatocellular carcinoma: a prospective study including transient elastography and cancer stem cell markers

Authors

Hend Ibrahim Shousha,Rabab Fouad,Tamer Mahmoud Elbaz,Dina Sabry,Mohamed Mahmoud Nabeel,Ahmed Hosni Abdelmaksoud,Aisha Mahmoud Elsharkawy,Zeinab Abdellatif Soliman,Ghada Habib,Ashraf Omar Abdelaziz

Journal

Arab Journal of Gastroenterology

Published Date

2020/6/1

Background and Study AimsTo investigate whether the measurement of liver stiffness (LSM) using fibroscan and the serum Cancer Stem Cells (CSC): Ep-CAM and cytokeratin-19, could predict the recurrence of hepatocellular carcinoma (HCC) and their impact on clinical outcome and overall survival.Patients and MethodsThis is a prospective study, including 179 HCV-related HCC patients. All patients were treated following the BCLC guidelines. All HCC patients had transient elastography, measurements of Ep-CAM and cytokeratin-19 before and six months post-treatment. We looked for predictors of recurrence and performed a survival analysis using Kaplan-Meier estimates.ResultsTACE was the most common procedure (77.1%), followed by microwave ablation (15.6%). Complete ablation was achieved in 97 patients; 55 of them developed HCC recurrence. After treatment, LSM increased significantly with a …

Anatomical variations of hepatic artery using the multidetector computed tomography angiography

Authors

SM Zaki,AHK Abdelmaksoud,BEA Khaled,IA Abdel Kader

Journal

Folia Morphologica

Published Date

2020

Background: The frequency of normal and aberrant hepatic arteries differs among ethnicities. The aim of our work was to study the frequency of normal and aberrant hepatic arteries among Egyptians using multidetector computed tomography (MDCT) and to compare our prevalence with the prevalence of other nationalities. In addition, the gender differences of such variations were clarified. Moreover, the arterial feeding of hepatic segment IV was determined.Materials and methods: The present study was carried out on 500 patients (409 males and 91 females). Abdominal CT was performed using two MDCT systems, a 64-row, and a 256-slice system.Results: According to Michel’s classification, the normal anatomy (type I) was observed in 369 (73.8%) cases, while anomalous hepatic arterial pattern was detected in 131 (26.2%) cases. These anomalies were distributed as follows: type II in 36 (7.2%) cases, type III in 60 (12%) cases, types IV and V in 5 cases for each (1% each), type VI in 14 (2.8%) and types VIII and IX in a single case for each (0.2% each). Neither type VII nor type X was detected. Nine (1.8%) unclassified cases were observed. According to Hiaat’s classification, the anomalies were distributed as follows: type II in 41 (8.2%) cases, type III in 74 (14.8%) cases, type IV in 6 (1.2%) cases, type V in a single case (0.2%) and type VI in 2 (0.4%) cases. Finally, 7 (1.4%) unclassified cases were observed. Common hepatic artery (CHA) originated from coeliac trunk in 98%(79.8% males and 18.2% females). It originated from the abdominal aorta in 0.4% and from the superior mesenteric artery (SMA) in 0.4%. It was absent in 1.2%. Right …

Machine learning prediction models for diagnosing hepatocellular carcinoma with HCV-related chronic liver disease

Authors

Somaya Hashem,Mahmoud ElHefnawi,Shahira Habashy,Mohamed El-Adawy,Gamal Esmat,Wafaa Elakel,Ashraf Omar Abdelazziz,Mohamed Mahmoud Nabeel,Ahmed Hosni Abdelmaksoud,Tamer Mahmoud Elbaz,Hend Ibrahim Shousha

Journal

Computer methods and programs in biomedicine

Published Date

2020/11/1

Background and ObjectiveConsidered as one of the most recurrent types of liver malignancy, Hepatocellular Carcinoma (HCC) needs to be assessed in a non-invasive way. The objective of the current study is to develop prediction models for Chronic Hepatitis C (CHC)-related HCC using machine learning techniques.MethodsA dataset, for 4423 CHC patients, was investigated to identify the significant parameters for predicting HCC presence. In this study, several machine learning techniques (Classification and regression tree, alternating decision tree, reduce pruning error tree and linear regression algorithm) were used to build HCC classification models for prediction of HCC presence.ResultsAge, alpha-fetoprotein (AFP), alkaline phosphate (ALP), albumin, and total bilirubin attributes were statistically found to be associated with HCC presence. Several HCC classification models were constructed using several …

Hepatocellular Carcinoma Multidisciplinary Clinic-Cairo University (HMC-CU) score: A new simple score for diagnosis of HCC

Authors

Ashraf Omar Abdelaziz,Mohamed Mahmoud Nabil,Dalia Abdelhamid Omran,Ahmed Hosni Abdelmaksoud,Noha Asem,Hend Ibrahim Shousha,Tamer Mahmoud Elbaz,Rania Leithy

Journal

Arab Journal of Gastroenterology

Published Date

2020/6/1

Background and Study AimsThe risk of hepatocarcinogenesis depends on background liver factors, of which fibrosis is a major determinant. Serum markers and scores are of increasing importance in non-invasive diagnosis of hepatic fibrosis. Our aim was to predict the occurrence of hepatocellular carcinoma (HCC) using a non-invasive fibrosis score calculated using routine patient data.Patients and mthodsOur retrospective study included 1,291 hepatitis C related-HCC Egyptian patients (Group 1) recruited from the multidisciplinary HCC clinic, Faculty of Medicine, Cairo University in the period between February 2009 and June 2016 and 1072 chronic hepatitis C-naïve patients (Group 2) with advanced fibrosis (≥F3) and cirrhosis (F4). King score, Fibro Q score, Aspartate aminotransferase-to-platelet ratio index (APRI), AST to ALT ratio (AAR), LOK score, Göteborg University Cirrhosis Index (GUCI), Fibro-α and …

See List of Professors in Abdelmaksoud A.H. Kamel University(Cairo University)

Abdelmaksoud A.H. Kamel FAQs

What is Abdelmaksoud A.H. Kamel's h-index at Cairo University?

The h-index of Abdelmaksoud A.H. Kamel has been 12 since 2020 and 14 in total.

What are Abdelmaksoud A.H. Kamel's top articles?

The articles with the titles of

Early Detection and prediction of survival of patients with Hepatocellular Carcinoma Using Transient Elastography

Role of Transient Elastography (Fibroscan) in Early prediction of Hepatitis C Virus Related Hepatocellular Carcinoma

Spontaneous vanishing of hepatocellular carcinoma: A case report of an extremely rare incident

Meta-learning algorithm development to predict outcomes in patients with hepatitis C virus-related hepatocellular carcinoma

Hepatic resection versus microwave ablation for the treatment of early hepatocellular carcinoma: a comparative analysis of treatment outcomes and survival predictors

Schistosoma mansoni infection and the occurrence, characteristics, and survival of patients with hepatocellular carcinoma: an observational study over a decade

Survival and recurrence rates of hepatocellular carcinoma after treatment of chronic hepatitis C using direct acting antivirals

Novel optical coherence tomography findings of a case of sympathetic ophthalmia after 23-gauge vitrectomy

...

are the top articles of Abdelmaksoud A.H. Kamel at Cairo University.

What are Abdelmaksoud A.H. Kamel's research interests?

The research interests of Abdelmaksoud A.H. Kamel are: Intervention Radiology

What is Abdelmaksoud A.H. Kamel's total number of citations?

Abdelmaksoud A.H. Kamel has 886 citations in total.

What are the co-authors of Abdelmaksoud A.H. Kamel?

The co-authors of Abdelmaksoud A.H. Kamel are Tamer Elbaz.

    Co-Authors

    H-index: 23
    Tamer Elbaz

    Tamer Elbaz

    Cairo University

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