AbdelKarim Kamel

AbdelKarim Kamel

Cairo University

H-index: 5

Africa-Egypt

Description

AbdelKarim Kamel, With an exceptional h-index of 5 and a recent h-index of 5 (since 2020), a distinguished researcher at Cairo University, specializes in the field of Biochemistry, Molecular Biology, Genetics.

Professor Information

University

Cairo University

Position

Lecturer of Medical Biochemistry Faculty of Medicine

Citations(all)

101

Citations(since 2020)

54

Cited By

57

hIndex(all)

5

hIndex(since 2020)

5

i10Index(all)

4

i10Index(since 2020)

2

Email

University Profile Page

Cairo University

Research & Interests List

Biochemistry

Molecular Biology

Genetics

Top articles of AbdelKarim Kamel

Association between CD3 as a Sensitive T Cells Lineage Marker and NAFLD

CD3 antigen represents the most specific as well the most sensitive T cells lineage marker, including NK and NKT. Aim and methods our study was to evaluate CD-3 in nonalcoholic steatohepatitis patients as a diagnostic and prognostic marker in such patients. Serum samples were collected from 41 NAFLD patients, in addition to 14 healthy subjects. They were recruited from the internal medicine department - Cairo University. All patients and controls were subjected to clinical assessment, abdominal ultrasound examination, laboratory assessment including liver function and enzymes, kidney function, and lipid profile. Fib-4 and NAFLD fibrosis score were calculated for all patients. Also, serum levels of CD-3 were detected by ELISA technique. Results The NAFLD patients group was divided into three groups: fifteen obese patients, fourteen diabetic patients, twelve obese patients with T2DM. BMI, HbA1C, and cholesterol levels were significantly elevated in the NAFLD cases compared with healthy controls (p<0.05). The mean serum level of CD3 was 64.53±84 ng/ml in NAFLD cases vs. 4.76±2.94 ng/ml in controls. Overall, there was a statistically significant increase in serum CD3 levels in NAFLD cases (p<0.001). Additionally, serum level of CD3 was significantly higher in the diabetic non-obese subjects and obese non-diabetic subjects when compared with the lean subjects (89.4±113.53 ng/ml and 60.91±73.76 vs. 4.76±2.94 ng/ml, P = 0. 003& 0.05; respectively. Conclusion Serum level of CD3 can be used as a prognostic marker in cases with NAFLD as they increase with the progression of the disease and is correlated with fibrosis stage.

Authors

Halla Mohamed Ragab,Nabila Abd El Maksoud,Mona A Amin,Abdelkarim Kamel,May Fawzi,Wafaa Abd Elaziz

Journal

Egyptian Journal of Chemistry

Published Date

2023/12/1

Soluble CD163 impact as a prognostic biomarker in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a malignant blood disorder in which there is an excess of white blood cells (lymphocytes) in blood and lymphoid tissues. CLL patients experience different clinical behaviors with diversity in disease course and outcome. Accordingly, prognostic markers are crucial for employing appropriate therapy protocols. CD163 (cluster of differentiation 163) is a monocyte/macrophage receptor. Soluble CD163 (sCD163) is an emerging prognostic player in the field of hematopoietic neoplasms. This study aimed to assess the prognostic potential of sCD163 as a serological marker in CLL. The study included 41 CLL patients and 44 apparently normal healthy volunteers as controls. Expression of CD38 and cytoplasmic ZAP-70 in CLL cells was assessed using flow cytometry. Beta 2 microglobulin (B2M), sCD23, and sCD163 serological markers were measured by ELISA. Serum levels of sCD163 were statistically significantly higher in CLL cases compared to controls (p= 0.000). sCD163 levels were positively correlated with absolute lymphocyte count, sCD23, and B2M levels (p= 0.027, p= 0.01, and p= 0.004, respectively). In conclusion, levels of sCD163 in CLL is a promising prognostic tool for evaluating disease progression.

Authors

Halla M Ragab,Hanaa RM Attia,Nabila A Maksoud,Mona H Ibrahim,Mai M Mohamed,Abdelkarim Kamel,Mohamed E Sobeih,Mohamed AM Kamal,Wafaa Abd Elaziz

Journal

The Egyptian Journal of Immunology

Published Date

2023/7/1

Glycemic Control in Adolescent Girls with Type 1 Diabetes Mellitus

Background Optimal glycemic control is essential during type 1 diabetes (T1D) management to minimize the occurrence of both short and long term complications. Many factors might influence diabetes control including puberty which is a challenging period. Aim of the work To assess the effect of puberty on glycemic control in adolescent females with T1D and to compare glucose levels, insulin demand and carbohydrate intake in the week of menstruation to those in the luteal phase. Methods This cross-sectional, pilot study took place in the Diabetes, Endocrine and Metabolism Pediatric Unit, Cairo University Children’s Hospital, Egypt. It included 30 prepubertal Tanner stage 1 girls (Group-1) and 30 full pubertal girls Tanner stage 5 (Group 2) with regular menstruation were included in the study. Mean blood glucose levels, insulin doses and glycated hemoglobin(HbA1C) (average of the last 4 readings over 1 year) were compared. Results Ages of enrolled girls ranged from 10-15 years (group 1: mean age ± SD=11.67±1.33; group 2: 13.93±.0.94; p < 0.001 ) with T1D durations of 5.12-5.42 years. Mean HbA1c and insulin doses were similar in both pubertal and prepubertal girls after adjusting data for BMI SDS and participation in exercise (p=0.164 and 0.157 respectively). Mean blood glucose levels, insulin doses and carbohydrate intake were significantly higher (by 8%, 18% and 7.5% respectively) during menstruation (early follicular) than in the luteal phase (p < 0.001). Conclusion Glycemic control in pubertal females with T1D was challenged by the higher BMI, lack of activity and growth spurt that characterize this stage of development …

Authors

Yomna Shaalan,Nora ElSaid Badawi,Aliaa Soliman,Abdelkarim Kamel,Marise Abdou

Journal

Pediatric Sciences Journal

Published Date

2022/1/1

Metabolic and Cardiac Effects of Growth Hormone Therapy in Children with Turner Syndrome

Background Turner Syndrome (TS) is the most frequent genetic defect in females. TS patients are characterized by growth failure, metabolic and cardiovascular abnormalities. Objective The study aimed at determining the influence of growth hormone (GH) therapy on TS patients' body composition, metabolic profile, and cardiac functioning. Patients and methods This clinical trial comprised 54 TS females divided into two subgroups; 29 TS females on GH medication ≥6 months (interventions) made up Group 1 and 25 TS females who didn't start treatment were in Group 2 (controls). Ages were between 6.01 and 17.1 years. Anthropometric measures, skin fold thickness measurements, body composition analysis and blood pressure were recorded. Fasting levels for lipids, blood glucose, and C-peptide were measured. Tissue Doppler Imaging (TDI), M-mode, complete two-dimensional, and Pulsed-Wave Doppler Echocardiography were performed. Results Patients with TS receiving GH therapy had significantly higher high density lipoprotein cholesterol (HDL-C), waist circumference (WC) for age, hip circumference, bone mass and impaired global myocardial function. Positive correlation between the age of initiating GH therapy and triglyceride levels were observed while negative correlation with height for age and muscle percentage. Homeostatic model assessment-insulin resistance (HOMA-IR) demonstrated a positive relationship with WC and the sum of skin fold thickness percentiles. Conclusion GH increases HDL-C, WC and bone mass. Increased WC and skinfold thickness are insulin resistance risk factors. Earlier age of patient at start of GH …

Authors

Marise Abdou,Abeer Atef,Mona Ahmed Gabr,Nora Badawi,Inas A Saad,Abdelkarim Kamel,Rodina Sobhy

Journal

The Egyptian Journal of Hospital Medicine

Published Date

2022/10/1

The validity of the Bayley-Pinneau method in predicting final adult height at the onset of puberty in patients with classic congenital adrenal hyperplasia

Introduction: The final adult height (FAH) of patients with congenital adrenal hyperplasia (CAH) is often lower than the predicted adult height (PAH) using the Bayley-Pinneau (B&P) method. The aim of the current work was to test the validity of B&P in predicting FAH from a bone age (BA) measurement performed at onset of puberty.

Authors

Nora Badawi,Lubna Fawaz,Ahmed Amin,Abdelkarim Kamel,Noha Arafa

Journal

Endokrynologia Polska

Published Date

2021

Professor FAQs

What is AbdelKarim Kamel's h-index at Cairo University?

The h-index of AbdelKarim Kamel has been 5 since 2020 and 5 in total.

What are AbdelKarim Kamel's research interests?

The research interests of AbdelKarim Kamel are: Biochemistry, Molecular Biology, Genetics

What is AbdelKarim Kamel's total number of citations?

AbdelKarim Kamel has 101 citations in total.

academic-engine

Useful Links