Abdelhamid Abdelhamid

Abdelhamid Abdelhamid

Mansoura University

H-index: 23

Africa-Egypt

Abdelhamid Abdelhamid Information

University

Mansoura University

Position

___

Citations(all)

2548

Citations(since 2020)

705

Cited By

1983

hIndex(all)

23

hIndex(since 2020)

13

i10Index(all)

85

i10Index(since 2020)

21

Email

University Profile Page

Mansoura University

Abdelhamid Abdelhamid Skills & Research Interests

Nutrition - Pollution - Environment - Animal & Fish Production

Top articles of Abdelhamid Abdelhamid

OPEN ACCESS EDITED BY

Objective: The present systematic review aimed to provide an overview of training load (TL), along with their responses, monitoring during training sessions in highly trained and elite adult women soccer players.Data source: Electronic databases searches (PubMed, Scopus, Web of Science and Ebsco) for relevant studies published in peer-reviewed journals were conducted, and eligibility criteria were based on the PICOS model in accordance with PRISMA guidelines.Study selection: Studies were considered as follows:(a) highly trained and elite adult (> 18 years) women's soccer players;(b) continuous (minimum1-week duration) TL monitoring in the context of the team routine;(c) TL collected from entire training session. Methodological qualitative assessments and risk of bias criteria were used for judging the studies.Data extraction: A total of 1,163 studies were identified, and 16 were included. The selected studies were fully screened to extract the population characteristics; the number of players; a type of study design; region where the study was performed; the main findings.Data synthesis: Accumulated external TL (ETL) during the pre-season was positively correlated to enhanced adaptations in intermittent exercise capacity. Daily ETL was negatively correlated to next-day self-reported fatigue and muscle soreness. Daily internal TL (ITL) was negatively correlated to postsession sleep duration and sleep efficiency. One study showed that higher accumulated player load and total distance were associated with injury.

Authors

José Luis Losada,Asier Gonzalez-Artetxe,Yousri Elghoul,Júlio A Costa,JA Costa,V Rago,P Brito,P Figueiredo,A Sousa,E Abade,J Brito

Journal

Community Series-Extremophiles: Microbial Genomics and Taxogenomics, Volume II

Published Date

2023/11/22

Evaluation of alternative non-traditional lipid sources in diet for Thinlip grey mullet, Liza ramada fingerlings

The principal purpose of the present trial is to inspect the complete supply of nutritional fish oil by substituting lipid springs in an applied feed for Thinlip grey-mullet, Liza ramada fingerlings. The impacts of four lipid sources (fish viscera oil (FVO), poultry viscera oil (PVO), tallow oil (TO), and plant oil (PO)) compared with fish oil (FO) as a basal diet on performance growth rates, feed-utilization, biochemical structure of the body, specific blood constraints, and fatty acid profile were evaluated in Thinlip grey mullet fingerlings. The substitution of FO by four substitute lipids shows a non-significant but notable influence on growth performance. On the other hand, feed utilization productivity was significant for fingerlings nourished by the PVO diet. Fingerlings nourished by the PO diet showed significantly lower contents of the total body lipid compared to fingerlings nourished by other diets. Flesh fatty acid structure reflected …

Authors

Mohamed M Toutou,Abdelhamid M Abdelhamid,Abdullah E Helmy,Abdelrahman S Abouzied,Mohamed M Refaey

Journal

The Egyptian Journal of Aquatic Research

Published Date

2023/6/1

Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease

Sickle cell disease (SCD) is a serious global health problem, and currently, the only curative option is hematopoietic stem cell transplant (HCT). However, myeloablative total body irradiation (TBI)-based HCT is associated with high mortality/morbidity in SCD patients. Therefore, reduced-intensity (2–4 Gy) total body radiation (TBI) is currently used as a conditioning regimen resulting in mixed chimerism with the rescue of the SCD disease characteristic features. However, donor chimerism gradually reduces in a few years, resulting in a relapse of the SCD features, and organ toxicities remained the primary concern for long-term survivors. Targeted marrow irradiation (TMI) is a novel technique developed to deliver radiation to the desired target while sparing vital organs and is successfully used for HCT in refractory/relapsed patients with leukemia. However, it is unknown if TMI will be an effective treatment for a hematological disorder like SCD without adverse effects seen on TBI. Therefore, we examined preclinical feasibility to determine the tolerated dose escalation, its impact on donor engraftment, and reduction in organ damage using our recently developed TMI in the humanized homozygous Berkley SCD mouse model (SS). We show that dose-escalated TMI (8:2) (8 Gy to the bone marrow and 2 Gy to the rest of the body) is tolerated with reduced organ pathology compared with TBI (4:4)-treated mice. Furthermore, with increased SCD control (AA) mice (25 million) donor BM cells, TMI (8:2)-treated mice show successful long-term engraftment while engraftment failed in TBI (2:2)-treated mice. We further evaluated the benefit of dose-escalated TMI …

Authors

Srideshikan Sargur Madabushi,Raghda Fouda,Hemendra Ghimire,Amr MH Abdelhamid,Ji Eun Lim,Paresh Vishwasrao,Stacy Kiven,Jamison Brooks,Darren Zuro,Joseph Rosenthal,Chandan Guha,Kalpna Gupta,Susanta K Hui

Journal

Frontiers in Oncology

Published Date

2022/9/6

The protective effect of xanthenone against LPS-induced COVID-19 acute respiratory distress syndrome (ARDS) by modulating the ACE2/Ang-1-7 signaling pathway

OBJECTIVE Acute respiratory distress syndrome (ARDS) is an inflammatory lung disease that has a high rate of morbidity and mortality. It’s an acute diffusive lung injury caused by the release of pro-inflammatory cytokines into the lungs. Specific microRNAs have been identified to play a crucial role in the renin-angiotensin system signaling pathways the main pathophysiological pathway responsible for ARDS. Since the ARDS life-threatening complication associated with COVID-19 is an ongoing challenge, this current study aimed to investigate the potential efficacy of xanthenone in the treatment of ARDS induced with LPS in mice through ACE2 activation and modulation of miR-200 and ACE2/Ang 1-7 pathways. MATERIALS AND METHODS Mice were categorized into three groups randomly. The first set of mice served as the normal control group. The ARDS group was injected with LPS (15 mg/kg; i.p.). The last group was treated with xanthenone (2 mg/kg/day; p.o.) for one week before the LPS injection. RESULTS Xanthenone treatment resulted in a significant down-regulation of miRNA-200 expression, leading to the activation of ACE2 accompanied with marked inhibition of Angiotensin II as well as increases the levels of Ang 1-7 and SP-A. CONCLUSIONS Xanthenone has the potential to be a promising therapeutic drug for the treatment of ARDS COVID-19 complication through activation of ACE2/Ang 1-7 pathways.

Authors

AM Abdelhamid,M El Deeb,MA Zaafan

Published Date

2022

Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice

Total body irradiation (TBI) is a commonly used conditioning regimen for hematopoietic stem cell transplant (HCT), but dose heterogeneity and long-term organ toxicity pose significant challenges. Total marrow irradiation (TMI), an evolving radiation preconditioning regimen for HCT can overcome the limitations of TBI by delivering the prescribed dose targeted to the bone marrow (BM) while sparing organs at risk. Recently, our group demonstrated that TMI up to 20 Gy in relapsed/refractory AML patients was feasible and efficacious, significantly improving 2-year overall survival compared to the standard treatment. Whether such dose escalation is feasible in elderly patients, and how the organ toxicity profile changes when switching to TMI in patients of all ages are critical questions that need to be addressed. We used our recently developed 3D image-guided preclinical TMI model and evaluated the radiation damage and its repair in key dose-limiting organs in young (~8 weeks) and old (~90 weeks) mice undergoing congenic bone marrow transplant (BMT). Engraftment was similar in both TMI and TBI-treated young and old mice. Dose escalation using TMI (12 to 16 Gy in two fractions) was well tolerated in mice of both age groups (90% survival ~12 Weeks post-BMT). In contrast, TBI at the higher dose of 16 Gy was particularly lethal in younger mice (0% survival ~2 weeks post-BMT) while old mice showed much more tolerance (75% survival ~13 weeks post-BMT) suggesting higher radio-resistance in aged organs. Histopathology confirmed worse acute and chronic organ damage in mice treated with TBI than TMI. As the damage was alleviated …

Authors

Ji Eun Lim,Srideshikan Sargur Madabushi,Paresh Vishwasrao,Joo Y Song,Amr MH Abdelhamid,Hemendra Ghimire,VL Vanishree,Jatinder K Lamba,Savita Dandapani,Amandeep Salhotra,Mengistu Lemecha,Antonio Pierini,Daohong Zhao,Guy Storme,Shernan Holtan,Cynthia Aristei,Dorthe Schaue,Monzr Al Malki,Susanta K Hui

Journal

Frontiers in Oncology

Published Date

2022/11/10

A Sparse Orthogonal Collimators System for Experiments on Small-Animal Scale

Purpose/Objective(s)Intensity-modulated radiotherapy (IMRT) is the clinical gold standard for concentrated dose delivery. However, IMRT for small animal experiments has faced paramount technical challenges, preventing effective clinical translation of preclinical experiments. Sparse orthogonal collimator (SOC) based on the Rectangular Aperture Optimization (RAO) framework is the first general-purpose small animal IMRT platform, but its original planning algorithm was inefficient for complex cases such as total marrow irradiation (TMI) of mice. Here we introduce a significantly improved optimization framework for efficient SOC-based treatment planning and demonstrate TMI efficacy.Materials/MethodsThe SOC system is designed and fabricated with four orthogonal, double-focused tungsten leaf pairs that are capable of forming two rectangles simultaneously. The rectangles were optimized using RAO. Since the …

Authors

L Jiang,Q Lyu,AMH Abdelhamid,SK Hui,K Sheng

Journal

International Journal of Radiation Oncology, Biology, Physics

Published Date

2022/11/1

Dietary polyethylene inclusion affecting rabbit's performance

A feeding experiment was conducted with rabbits as experimental animals for 2 months at 4 treatment groups under the same environmental conditions. The aim was to study the toxic effects of dietary graded levels of polyethylene (PE, 0, 1, 2, and 4 g/ton diet). The main effects were that some animals fed the PE-contaminated diets suffered from mange, diarrhea, weakness, and/or loss of weight. Post-mortem examination of the contaminated-diets fed rabbit revealed presence of bad smell liquids in its abdomen, residues of collective PE in the small intestine, collective feces in one part of the intestine and the parts were filled with aqueous accumulation, the color of one hepatic lobule was pale, and the lungs' color was bloody red. Yet, feed intake and water consumption increased by feeding the contaminated diets. Moreover, animals offered the contaminated diets reflected heavier body weight. However, the feed conversion (utilization) was negatively affected by the PE-contaminated diet; since, dietary PE-inclusion increased apparently feed consumption than the real body weight gain. Slaughter test of the PE-treated animals reflected many remarks including loss of rabbit's weight; increased skin weight, skin was thick and dough, changes in the color and quality of the carcass flesh, easy broken bone. When these animals were eviscerated, it were observed white-colored lungs, with necrosis and bloody infiltration, small-sized liver, with blackly-red color, enlarged gall bladder, narrow diameter of the small intestine, presence of collective mass of PE on the internal wall of the small intestine. The presence of PE in the experimental diets was …

Authors

Abdelhamid M Abdelhamid,Ahmed AM Abdel Hamid,Mahmoud AE Hassan,Manar A Almnsy,Adel EM Ibrahim

Journal

Journal of Applied Science, Engineering, Technology, and Education

Published Date

2021/11/23

The cardioprotective effect of astaxanthin against isoprenaline-induced myocardial injury in rats: involvement of TLR4/NF-κB signaling pathway.

OBJECTIVE: Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality around the world. Nuclear transcription factor kappa B (NF-κB) represents a factor that plays a major role in the pathogenesis of CVDs. The current study aims to investigate the modulatory effects of astaxanthin and its molecular mechanisms in rats with isoprenaline-induced myocardial infarction. MATERIALS AND METHODS: Rats were pretreated with astaxanthin daily for 14 days prior to inducing myocardial infarction with isoprenaline in the final two days. Blood and heart tissue samples were collected 24 hours after the last dose of isoprenaline was injected for biochemical and histological analysis. RESULTS: Isoprenaline-induced myocardial injury was demonstrated with histopathological examination of heart tissue and the significantly elevated serum troponin-I. Isoprenaline caused an increase in oxidative stress and a decrease in antioxidants. Toll-like receptor-4 (TLR4), NF-κB and tumor necrosis factor-α (TNF-α) expression levels were significantly higher in infarcted rats. Astaxanthin pretreatment had a significant preventive effect on all of the biochemical and molecular parameters tested in myocardial infarcted rats. CONCLUSIONS: Astaxanthin’s cardioprotective effect has been linked to the inhibition of the TLR4/NF-κB signaling pathway. This inhibits the release of inflammatory cytokines, which can cause myocardial cell death. Because of its antioxidant and anti-inflammatory properties, astaxanthin is a promising cardioprotective agent.

Authors

MA Zaafan,AM Abdelhamid

Journal

European Review for Medical & Pharmacological Sciences

Published Date

2021/6/1

Comparison between blood haematology of Egyptian freshwater food fish and ornamental fish

The present study was carried out to compare between some freshwater food fish species and some other freshwater ornamental fish species commonly known in Egypt, concerning the haematological parameters, dressing percent, fillet (boneless meat) percentage, and chemical composition of the fish flesh on dry matter basis. Four food fish species (Nile tilapia, grass carp, catfish, and Tobara from Manzalah Fish Farm, Dakahlia governorate, General Authority For Developing Fish Wealth, Ministry of Agriculture, Cairo, Egypt) and two ornamental fish (Koi and Fan-tail (Goldfish), from local ornamental fish trade shops, Mansoura, Dakahlia governorate, Egypt) species all belonging to the freshwater fishes were sampled, three fishes from each. Body measurements of the individual fishes were recorded, blood samples were withdrawn, live body weight was recorded, fish were dressed (eviscerated) and filleted, the flesh were minced, dried, and sieved for chemical analysis. From the forgoing results, it could be concluded that the worthiness comparison among fish species for physical, biochemical and haematological parameters, and fish quality must be done between similar species, sex, size, physiological status, nutritional status, rearing system. These parameters are variable and influenced by genetically and environmental aspects.

Authors

Abdelhamid Mohamed Abdelhamid,Mohamed Moaaz Refaey,Hazem Ga'far Mohammed El-Sayed,Gehad Ahmed Mo'aty

Journal

Journal of Applied Science, Engineering, Technology, and Education

Published Date

2021/4/20

The cardioprotective effect of microRNA-103 inhibitor against isoprenaline-induced myocardial infarction in mice through targeting FADD/RIPK pathway

OBJECTIVE The current study investigates the effect of the innovative phosphorothioate modified backbone locked nucleic acid (LNA) of microRNA-103 (miR-103) specifically designed for systemic delivery in the silencing of miR-103 in experimentally induced myocardial infarction (MI). MicroRNA-103 is a small non-coding RNA which regulates Fas-associated protein with death domain (FADD) gene expression, which is a negative regulator for necroptosis occurs during the progression of MI. MATERIALS AND METHODS Experimental male mice were allocated into three groups; the first group received normal saline, the second group was injected with isoprenaline and served as the infarcted control, while the third group was treated with LNA miR-103 power inhibitor before isoprenaline injection. Blood and heart samples were used for biochemical analysis of miR-103, FADD, receptor interacting protein kinase (RIPK), nuclear factor-κβ, tumor necrosis factor-α, interleukin-6, troponin-I and creatine kinase-MB (CK-MB) as well as the histological examination of heart tissue. RESULTS The treated mice showed marked improvement in the troponin-I and CK-MB levels with almost normal histological structure of heart tissue. Significant inhibition of miR-103 accompanied by increased FADD expression and markedly decreased expression of the other biomarkers were observed in the hearts of the treated mice. CONCLUSIONS LNA miR-103 inhibitor is a potent cardioprotective agent and can be a promising treatment against MI through targeting FADD/RIPK …

Authors

MA Zaafan,Amr Abdelhamid

Published Date

2021

Productive and immunological responses of broiler chicks to supplementation of different copper forms

Two hundred and ten unsexed broiler chicks (Arbor Acres) at 7 day of age were used to study the effect of dietary supplementation of different Copper (Cu) forms i.e. inorganic (copper sulfate, CuSO4), organic (copper methionine Cu2-Met) or nano inorganic copper particles (Cu-NP) on the productive performance, hematological and biochemical constituents of blood and immune response of broiler chicks. They were randomly divided into seven dietary treatments with five replicate cages per treatment, six chicks for each. The first group was fed the basal diet without any supplementation (control); while the 2nd and 3rd groups were fed the same diet supplemented with 50 and 100 ppm of inorganic Cu (copper sulfate, CuSO4), respectively. The 4th and 5th groups were fed the basal diet supplemented with 50 and 100 ppm of organic Cu (copper methionine Cu2-Met), respectively. The 6th and 7th groups were fed the basal diet supplemented with 50 and 100 ppb of nano inorganic copper (Cu-NP), respectively. Results showed that chicks fed the basal diet supplemented with different forms of Cu had significantly better LBW, BWG, FCR, economic efficiency and production index. Both organic and nano Cu-fed groups showed significantly better productive performance traits compared with the inorganic Cu – fed groups. Supplementation of different Cu forms decreased serum levels of total lipids, triglycerides, cholesterol, low density lipoprotein (LDL), whereas RBCs count, hemoglobin, PCV, glucose, globulin, thyroid hormones (T3-T4), immunoglobulin (IgM, IgG), and antioxidant enzymes activity (TAC– GPX- GSH-SOD) were significantly increased …

Authors

Ibraheim El-Wardany,Abdel-Hamid Abdel-Hamid,Ayman Morsi

Journal

Arab Universities Journal of Agricultural Sciences

Published Date

2020/9/30

See List of Professors in Abdelhamid Abdelhamid University(Mansoura University)

Abdelhamid Abdelhamid FAQs

What is Abdelhamid Abdelhamid's h-index at Mansoura University?

The h-index of Abdelhamid Abdelhamid has been 13 since 2020 and 23 in total.

What are Abdelhamid Abdelhamid's top articles?

The articles with the titles of

OPEN ACCESS EDITED BY

Evaluation of alternative non-traditional lipid sources in diet for Thinlip grey mullet, Liza ramada fingerlings

Development and characterization of a preclinical total marrow irradiation conditioning-based bone marrow transplant model for sickle cell disease

The protective effect of xanthenone against LPS-induced COVID-19 acute respiratory distress syndrome (ARDS) by modulating the ACE2/Ang-1-7 signaling pathway

Total marrow irradiation reduces organ damage and enhances tissue repair with the potential to increase the targeted dose of bone marrow in both young and old mice

A Sparse Orthogonal Collimators System for Experiments on Small-Animal Scale

Dietary polyethylene inclusion affecting rabbit's performance

The cardioprotective effect of astaxanthin against isoprenaline-induced myocardial injury in rats: involvement of TLR4/NF-κB signaling pathway.

...

are the top articles of Abdelhamid Abdelhamid at Mansoura University.

What are Abdelhamid Abdelhamid's research interests?

The research interests of Abdelhamid Abdelhamid are: Nutrition - Pollution - Environment - Animal & Fish Production

What is Abdelhamid Abdelhamid's total number of citations?

Abdelhamid Abdelhamid has 2,548 citations in total.

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