Abdelfattah El Ouaamari

Abdelfattah El Ouaamari

Rutgers, The State University of New Jersey

H-index: 16

North America-United States

Abdelfattah El Ouaamari Information

University

Rutgers, The State University of New Jersey

Position

Assistant Professor in Medicine at

Citations(all)

1684

Citations(since 2020)

853

Cited By

1182

hIndex(all)

16

hIndex(since 2020)

14

i10Index(all)

20

i10Index(since 2020)

18

Email

University Profile Page

Rutgers, The State University of New Jersey

Abdelfattah El Ouaamari Skills & Research Interests

Diabetes

Top articles of Abdelfattah El Ouaamari

State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis

Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy homeostasis. Glucagon-like peptide-1 (GLP-1, encoded by Gcg), secreted by a distinct population of neurons located within the nucleus tractus solitarius (NTS), suppresses feeding through projections to multiple brain targets 1-3. Although GLP-1 analogs are proven clinically effective in treating type 2 diabetes and obesity 4, the mechanisms of GLP-1 action within the brain remain unclear. Here, we investigate the involvement of GLP-1 receptor (GLP-1R) mediated signaling in a descending circuit formed by GLP-1R neurons in the paraventricular hypothalamic nucleus (PVN GLP-1R) that project to dorsal vagal complex (DVC) neurons of the brain stem in mice. PVN GLP-1R→ DVC synapses release glutamate that is augmented by GLP-1 via a presynaptic mechanism. Chemogenetic activation of PVN GLP-1R→ DVC neurons suppresses feeding. The PVN GLP-1R→ DVC synaptic transmission is dynamically regulated by energy states. In a state of energy deficit, synaptic strength is weaker but is more profoundly augmented by GLP-1R signaling compared to an energy-replete state. In an obese state, the dynamic synaptic strength changes in the PVN GLP-1R→ DVC descending circuit are disrupted. Blocking PVN GLP-1R→ DVC synaptic release or ablation of GLP-1R in the presynaptic compartment increases food intake and causes obesity, elevated blood glucose, and impaired insulin sensitivity. These findings suggest that the state-dependent synaptic plasticity in this PVN GLP-1R→ DVC descending circuit mediated by GLP-1R signaling is an …

Authors

Zhiping Pang,Le Wang,Rohan Savani,Matteo Bernabucci,Yi Lu,Ishnoor Singh,Wei Xu,Abdelfattah El Ouaamari,Michael Wheeler,Harvey J Grill,Mark Rossi

Published Date

2024/3/12

Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion

Sensory neurons in the dorsal root ganglia (DRG) convey somatosensory and metabolic cues to the central nervous system and release substances from stimulated terminal endings in peripheral organs. Sex‐biased variations driven by the sex chromosome complement (XX and XY) have been implicated in the sensory–islet crosstalk. However, the molecular underpinnings of these male–female differences are not known. Here, we aim to characterize the molecular repertoire and the secretome profile of the lower thoracic spinal sensory neurons and to identify molecules with sex‐biased insulin sensing‐ and/or insulin secretion‐modulating activity that are encoded independently of circulating gonadal sex hormones. We used transcriptomics and proteomics to uncover differentially expressed genes and secreted molecules in lower thoracic T5‐12 DRG sensory neurons derived from sexually immature 3‐week‐old …

Authors

Sohyun Moon,Lamyaa Alsarkhi,Tai‐Tu Lin,Ryota Inoue,Azeddine Tahiri,Cecilia Colson,Weikang Cai,Jun Shirakawa,Wei‐Jun Qian,Jerry Yingtao Zhao,Abdelfattah El Ouaamari

Journal

The FASEB Journal

Published Date

2023/10

Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases: workshop proceedings

The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report provides a summary of the proceedings from the workshop. The goals of the workshop were to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into six major theme areas, including 1) pancreas anatomy and physiology, 2) diabetes in the setting of exocrine disease, 3) metabolic influences on the exocrine pancreas, 4) genetic drivers of pancreatic diseases, 5) tools for integrated pancreatic analysis, and 6) implications of exocrine–endocrine cross talk. For each theme, multiple presentations were followed by panel discussions on specific topics …

Authors

Teresa L Mastracci,Minoti Apte,Laufey T Amundadottir,Alexandra Alvarsson,Steven Artandi,Melena D Bellin,Ernesto Bernal-Mizrachi,Alejandro Caicedo,Martha Campbell-Thompson,Zobeida Cruz-Monserrate,Abdelfattah El Ouaamari,Kyle J Gaulton,Andrea Geisz,Mark O Goodarzi,Manami Hara,Rebecca L Hull-Meichle,Alexander Kleger,Alison P Klein,Janel L Kopp,Rohit N Kulkarni,Mandar D Muzumdar,Anjaparavanda P Naren,Scott A Oakes,Søren S Olesen,Edward A Phelps,Alvin C Powers,Cherie L Stabler,Temel Tirkes,David C Whitcomb,Dhiraj Yadav,Jing Yong,Norann A Zaghloul,Stephen J Pandol,Maike Sander

Journal

Diabetes

Published Date

2023/4

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

BackgroundCentral nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well understood.ResultsWe analyzed the distribution of GLP-1R-expressing neurons and axonal projections of NTS GLP-1-producing neurons in the mouse brain. GLP-1R neurons were found to be broadly distributed in the brain and specific forebrain regions, particularly the hypothalamus, including the arcuate nucleus of the hypothalamus (ARC), a brain region known to regulate energy homeostasis and feeding behavior, that …

Authors

Ishnoor Singh,Le Wang,Baijuan Xia,Ji Liu,Azeddine Tahiri,Abdelfattah El Ouaamari,Michael B Wheeler,Zhiping P Pang

Journal

Cell & Bioscience

Published Date

2022/10/29

Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells

The regulation of glucose-stimulated insulin secretion and glucose excursion has a sensory component that operates in a sex-dependent manner.ObjectiveHere, we aim to dissect the basis of the sexually dimorphic interaction between sensory neurons and pancreatic β cells and its overall impact on insulin release and glucose homeostasis.MethodsWe used viral retrograde tracing techniques, surgical and chemodenervation models, and primary cell-based co-culture systems to uncover the biology underlying sex differences in sensory modulation of pancreatic β-cell activity.ResultsRetrograde transsynaptic labeling revealed a sex difference in the density of sensory innervation in the pancreas. The number of sensory neurons emanating from the dorsal root and nodose ganglia that project in the pancreas is higher in male than in female mice. Immunostaining and confocal laser scanning microscopy confirmed the …

Authors

Sara McEwan,Hyokjoon Kwon,Azeddine Tahiri,Nivetha Shanmugarajah,Weikang Cai,Jin Ke,Tianwen Huang,Ariana Belton,Bhagat Singh,Le Wang,Zhiping P Pang,Ercument Dirice,Esteban A Engel,Abdelfattah El Ouaamari

Journal

Molecular Metabolism

Published Date

2021/11/1

Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue

Insulin and IGF-1 are essential for adipocyte differentiation and function. Mice lacking insulin and IGF-1 receptors in fat (FIGIR-KO, fat-specific IGF-1 receptor and insulin receptor–KO) exhibit complete loss of white and brown adipose tissue (WAT and BAT), glucose intolerance, insulin resistance, hepatosteatosis, and cold intolerance. To determine the role of FOXO transcription factors in the altered adipose phenotype, we generated FIGIR-KO mice with fat-specific KO of fat-expressed Foxos [Foxo1, Foxo3, Foxo4] (F-Quint–KO). Unlike FIGIR-KO mice, F-Quint–KO mice had normal BAT, glucose tolerance, insulin-regulated hepatic glucose production, and cold tolerance. However, loss of FOXOs only partially rescued subcutaneous WAT and hepatosteatosis, did not rescue perigonadal WAT or systemic insulin resistance, and led to even more marked hyperinsulinemia. Thus, FOXOs play different roles in insulin/IGF-1 …

Authors

Erica P Homan,Bruna B Brandão,Samir Softic,Abdelfattah El Ouaamari,Brian T O’Neill,Rohit N Kulkarni,Jason K Kim,C Ronald Kahn

Journal

The Journal of clinical investigation

Published Date

2021/10/1

Abdelfattah El Ouaamari FAQs

What is Abdelfattah El Ouaamari's h-index at Rutgers, The State University of New Jersey?

The h-index of Abdelfattah El Ouaamari has been 14 since 2020 and 16 in total.

What are Abdelfattah El Ouaamari's top articles?

The articles with the titles of

State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis

Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion

Integrated physiology of the exocrine and endocrine compartments in pancreatic diseases: workshop proceedings

Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake

Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells

Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue

are the top articles of Abdelfattah El Ouaamari at Rutgers, The State University of New Jersey.

What are Abdelfattah El Ouaamari's research interests?

The research interests of Abdelfattah El Ouaamari are: Diabetes

What is Abdelfattah El Ouaamari's total number of citations?

Abdelfattah El Ouaamari has 1,684 citations in total.

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